We're heading to Barcelona in a few weeks for CHPI and can't wait to meet with you! Schedule a meeting with our team of experts or find us at Stand 3H20 to discover how BIOVECTRA can best support your upcoming projects. Our team is available to discuss your most complex challenges including: - Biologics and available capacity at our microbial fermentation suites - Our pDNA, mRNA, and LNP manufacturing capabilities and state-of-the-art process development and biomanufacturing facilities - Synthetic small molecules - Bioreagents - Highly potent APIs Our unique, custom systems are designed to deliver solutions quickly and efficiently and our extensive regulatory expertise is backed by long-standing relationships with major regulatory bodies. Schedule time with us today! https://ow.ly/KLzA50PGyFm #CPHIBarcelona #CPHI #CPhIWorldwide #CDMO #HPAPIs #biologics #pDNA #mRNA #fermentation #syntheticsmallmolecules #bioreagents #MPEGs #synthesis #complexchemistry #biomanufacturing #lifesciences #biosciences #therapeutics #fillfinish
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How can #LabChip lead to better biologics and a better understanding of biologic samples? ❗ This paper documents a high-throughput approach to 2-dimensional protein separation. By combining strong anion exchange chromatography (SAX-HPLC) and Capillary-Electrophoresis with SDS (#CE-SDS), the authors quantify proteins from cell lysates and human serum. With this approach, datasets that would normally take days to gather can be analyzed in an afternoon! ❗❗ See the full text here: https://lnkd.in/gDMynSUQ #celllinedevelopment #microfluidics #antibodies #revvity #biologics #processdevelopment
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Programmable medicines hold immense significance as they embody drugs designed with customizable features and functions. Crafted using biological 'programming languages,' these medicines allow for precise design and execution, revolutionizing the way we approach medical treatments. At Constructive Bio, we specialize in creating programmable medicines, utilizing a vast array of building blocks. Our approach is grounded in the 'recoded life method,' which is renowned for its unprecedented fidelity, specificity, and scalability, enabling us to pioneer new frontiers in medical treatment. Non-canonical building blocks are crucial because they serve as the carriers of desirable characteristics. Discover the underlying concept driving the latest advancements in precision biologics and biomolecule innovation by reading below.
Constructive Bio is a programmable biomolecules company. As a pioneering company in programmable biomolecules, we specialize in crafting bespoke exotic proteins and peptides. Our products are advanced biologics, including peptides with non-canonical amino acids, engineered cytokines, antibody-drug conjugates (ADCs), and high-performance enzymes. This marks just the start of our journey. To discover more about our innovative processes and groundbreaking work, delve into the detailed insights provided in our whitepaper below. #biologics #adcs #bioengineering
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Check out our latest #blog featuring Eric Miller to learn how our new and innovative solution- LabZient™, was designed to revolutionize the assessment and validation process of large molecules like antibodies and bioconjugates. Eric shares, "By employing predictable and standardized methods, LabZient™ not only hastens the journey towards an IND application but also boosts overall efficiency and reduces risks. This is particularly advantageous for biotech companies aiming for rapid market entry, as it enables them to navigate the development process more swiftly and effectively." Access the article: https://lnkd.in/gPkrrBPc #analyticalmethoddevelopment #CDMO #biologics #antibodies
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Everyone wants biotherapeutics that are efficacious, stable, and easy to produce. Too bad this doesn't just happen on its own... How can scientists engineer their biologics to meet those criteria? Let's look at an example! ❗ A team from Pfizer utilized #FcFusion technology and #glycanengineering to significantly enhance the production profile, efficacy, and in-serum stability of a GDF-15 protein to treat weight loss. ❗ ❗ Side Note: While engineering the glycosylation profile of their mutants, they used the #LabChip GXII Touch from Revvity to quickly measure glycan occupancy and profile. ❗ ❗ ❗ Check out the full text here: https://lnkd.in/gaU4CwXm #biologics #revvity #proteinengineering #capillary #electrophoresis #antibodies #fusion #glycans #medicine #structuralbiology
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If you're interested in reading about the #labChip capabilities for Proteomics, check out this publication below by one of our Revvity #labchip experts! 😃 #LabChip #innovation #microfluidics #proteomics #lifescience #revvity
How can #LabChip lead to better biologics and a better understanding of biologic samples? ❗ This paper documents a high-throughput approach to 2-dimensional protein separation. By combining strong anion exchange chromatography (SAX-HPLC) and Capillary-Electrophoresis with SDS (#CE-SDS), the authors quantify proteins from cell lysates and human serum. With this approach, datasets that would normally take days to gather can be analyzed in an afternoon! ❗❗ See the full text here: https://lnkd.in/gDMynSUQ #celllinedevelopment #microfluidics #antibodies #revvity #biologics #processdevelopment
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At last month's American Biomanufacturing Summit, our Sr. Director of MSAT, Dennis Yoon, presented on Abzena's approach to scaling up and manufacturing biologics in: "Navigating a Complex Downstream #Manufacturing Strategy to Ensure Clinical & Commercial Success." From the importance of an established routine to the required expertise, process trains, and single-use technologies, he offered insights into what is needed to establish a solid foundation for success for your antibody. If you're starting to plan for your clinical or commercial manufacturing program, connect with our team today to learn how we can seamlessly take your biologic from benchtop to commercial scale manufacturing: https://lnkd.in/gKDnVFEB #CDMO #CRO #biologics #drugsubstance
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Each drug's unique biochemistry calls for a tailored approach. We understand that biotech companies face challenges like stability, aggregation, and interaction with excipients. Paired with a biophysical approach that provides greater accuracy in predictions, the Tanvex platform stands out by predicting potential hurdles and enabling rapid, informed decision-making. Read how Tanvex CDMO is revolutionizing formulation development and contributing to the accelerated timelines of drug development in Pawel Stanczak's article: https://lnkd.in/eVuKyqjH #biologics #cdmo #pharmaindustry #lifesciences
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We are excited to be a part of Festival of Biologics scheduled on 10-12 October at Basel, Switzerland. Meet Ajay Babu Gopaluni, Senior Manager, Business Development, at booth #200 to understand how Aragen can partner with you in overcoming your drug discovery challenges. With nearly three decades of experience, we deliver integrated and standalone solutions for large molecules from our research facilities located in California, USA. Our expertise spans Cell Line Development, offering royalty-free CHO platforms, and comprehensive antibody discovery services. Our proprietary RapTr2022 platform is best suited to produce difficult-to-express proteins and has a strong track record of successfully engineering cell lines for timely delivery of more than 100 CLD projects, majority of which have resulted in IND applications. We provide upstream and downstream services, optimizing media, assessing developability, and characterizing products. Aragen's advanced analytics enhance quality, mitigate risk, and expedite timelines for recombinant proteins. Write to us at bd@aragen.com to schedule a meeting during the event to discuss how we can partner with you in accelerating your projects. #FestivalofBiologics #Biologics #LargeMolecule #AntibodyDiscovery #Development #CellLineDevelopment #ProcessDevelopmet #Downstream #Upstream #Aragen #AragenLifeSciences #Basel #Switzerland
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Assessment of CQA in mRNA-LNP modality is essential to ensure product quality. They can influence: 🔹 Potency 🔹 Stability 🔹 Toxicity 🔹 Risk assessment relevant to mRNA-LNP modality This white paper is the first of a 3-part series written in partnership with CATUG. Stay tuned to learn more about ADC’s and mAb’s later in this series. For more information, visit: https://lnkd.in/eeg42_hj #CrystalBio #CATUGCrystal #CrystalPharmatech #CATUG #PharmaceuticalScience #Biologics #CMC #Biotech #DrugDevelopment #Research #Technology #API #CRO #CDMO
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It’s good to see the analytical approaches to assess CQA under regulatory guidance.
Assessment of CQA in mRNA-LNP modality is essential to ensure product quality. They can influence: 🔹 Potency 🔹 Stability 🔹 Toxicity 🔹 Risk assessment relevant to mRNA-LNP modality This white paper is the first of a 3-part series written in partnership with CATUG. Stay tuned to learn more about ADC’s and mAb’s later in this series. For more information, visit: https://lnkd.in/eeg42_hj #CrystalBio #CATUGCrystal #CrystalPharmatech #CATUG #PharmaceuticalScience #Biologics #CMC #Biotech #DrugDevelopment #Research #Technology #API #CRO #CDMO
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