BIOVIA’s Post

🔬 Is your research being slowed down by traditional drug discovery methods? We’re bridging the gap between computer-based modeling and laboratory validation to streamline the entire drug discovery process—saving time, resources, and effort. 🧬 Our all-in-one solution includes: In Silico Drug Discovery: Virtual screening & molecular docking Structure-based drug design Machine learning-based drug prediction Pharmacophore modeling & hit identification In Vitro Validation: High-throughput screening assays Cell culture & biochemical assays Enzyme inhibition & receptor-ligand interaction studies Toxicity profiling & ADMET analysis 💡 Benefits of our approach: Efficiency: Fast-track drug discovery to validation. Cost-Effectiveness: Reduce trial-and-error costs. Expertise: Access specialized teams in both computational biology and wet lab research. Integration: Smooth transition from predictions to lab results. 📈 Ready to accelerate your research? Contact us today to explore how we can help take your project from in silico predictions to in vitro discoveries! 🚀 #DrugDiscovery #InSilico #InVitro #BioTech #ResearchCollaboration #Innovation

‘A lazy chemist is a good chemist’ 👨🔬 Joachim Van Guyse is an assistant professor at the Leiden Academic Centre for Drug Research. His research focuses on biocompatible polymers: an important component for therapeutic particles, such as the mRNA vaccines used to combat SARS-CoV-2 during the COVID-19 pandemic. Van Guyse's latest publication shows an easier method to produce polymers that can be quickly and reliably modified accordingly. This way, different nanoparticles can be produced in a more efficient way, making it easier to screen large batches of molecules for therapeutic purposes 💪 Van Guyse used his polymers to assemble a SARS-CoV-2 vaccine, and compared this to the original vaccine 💉 He studied the immune response to both vaccines in live mice and saw no difference in functionality 🐭 This method of polymer production opens doors for optimising existing and discovering new nanotherapeutics. Read the publication here:  https://lnkd.in/gNk_gqnZ #LACDR #polymers #nanotherapeutics #leidenscience Zlata Nagorna Innovation Center of NanoMedicine (iCONM)

VHH, or variable domain of heavy chain of IgG, refers to a unique type of antibody found in camelids such as llamas and camels. These antibodies possess remarkable properties, including small size, high stability, and exceptional binding specificity. By harnessing the power of VHH antibodies, researchers can target a wide range of antigens with precision and efficacy. Our #VHHLibraryConstruction service empowers researchers to tap into this vast potential by offering custom-built VHH libraries tailored to their specific needs. Whether you're investigating novel therapeutic targets, developing diagnostic assays, or exploring new avenues in biotechnology, our expert team is here to support your endeavors every step of the way. https://lnkd.in/gewEkHqE #KMDBioscience #VHHLibraryConstruction #AntibodyDiscovery #Biotechnology #Innovation #ResearchExcellence

I recently attended the "Advances in Drug Discovery and Development 2024" symposium, and it was truly an eye-opening experience! 🌟 💊 From exploring AI-driven drug discovery, biomolecular engineering to leveraging quantum modeling and machine learning in drug development, the sessions shed light on how cutting-edge technology is shaping the future of medicine. Here are some of the key takeaways: 💡 Quantum modeling and machine learning are generating billions of novel compounds with enhanced binding, streamlining the drug discovery process. 🔬 Use of A.I generative models is expediting antibiotic discovery by creating novel compounds from existing repurposing drug banks with to combat AMR. 🧬 Small molecule ligands for RNA-targeted therapies are emerging as a frontier in precision medicine, opening doors to treatments for previously untreatable conditions. These sessions have enabled me to truly appreciate how the nature of drug discovery and development industry is truly interdisciplinary and is always evolving as new technologies and innovations arise! 💫 A huge thank you to Technology Networks for organizing such a thought-provoking event with an incredible line-up of speakers. I'm excited to see how these innovations will drive the next wave of pharmaceutical and biopharmaceutical breakthroughs! 🚀 #drugdiscovery #precisionmedicine #innovation #drugdevelopment #pharmacy #onlinesymposium

We’re excited to announce our collaboration with Bristol Myers Squibb applying Menten AI’s generative AI platform to peptide optimization. By leveraging Menten AI’s generative AI platform and the team’s expertise, we were able to explore a more expansive chemical space and identify new amino acid modifications to improve the desired properties of peptide macrocycles. It’s been a pleasure working with the world-class scientists at Bristol Myers Squibb. Thank you for the incredible collaboration! This is a key milestone for Menten AI, as it demonstrates the maturity of our platform and of generative AI more broadly, to accelerate the discovery and optimization of next-generation peptide macrocycles. Learn more about this collaboration: https://lnkd.in/dcW-8bdq #aidrugdiscovery #genai #biotech #drugdiscovery #peptides #hitdiscovery #drugdiscovery #drugdevelopment #peptides #peptidetherapy #cyclicpeptides #macrocycles  #artificialintelligence #ai #generativeai #therapeutics  #aminoacids #chemicalspace #mentenai #partnering #biotechnology #innovation #machinelearning #ml

#𝐀𝐢𝐎𝐫𝐍𝐨𝐭𝐀𝐢: 𝐖𝐢𝐥𝐥 𝐀𝐥𝐩𝐡𝐚𝐅𝐨𝐥𝐝 𝟑 𝐞𝐧𝐚𝐛𝐥𝐞 𝐬𝐜𝐢𝐞𝐧𝐭𝐢𝐟𝐢𝐜 𝐛𝐫𝐞𝐚𝐤𝐭𝐡𝐫𝐨𝐮𝐠𝐡𝐬? 🌐 #AlphaFold3 by Google DeepMind expands beyond proteins to predict structures of #DNA, #RNA, and ligands crucial for drug discovery. This broadens its application to fields like crop resilience and vaccine development. 🔬 The ability of AlphaFold 3 to predict interactions between proteins and small molecules, like potential drug compounds, enhances its utility in biopharmaceutical research. However, the model's impact is contingent on its prediction accuracy, which can vary significantly across different molecule interactions. Despite these variations, the tool offers a more efficient starting point for research compared to traditional experimental methods. 💰 Nevertheless, AlphaFold 3 comes with restricted access compared to its open-source predecessor, limiting its use to noncommercial purposes and constraining the range of molecules that can be studied. This may impede its integration into broader scientific research. Inspired by Massachusetts Institute of Technology Credit for video to YouTube Channel “AI Revolution” Might be interesting to Aljoscha Brandt Belén Garijo #AI #Science #Biopharmacy  Google

Optimize your microfluidic drug testing platforms with our specialized primary cells. Gain deeper insights into cellular responses with a focus on precise functionality. Call +91-965-4321-400 to get a quotation for primary and stem cells for your research. #primarycells #cellculture #drugtesting #research #microfluidics #drugdiscovery #biotech #science #BIORESEARCH

Membrane proteins are essential gatekeepers of cellular function, forming channels, receptors, and enzymes that control the flow of information and materials into and out of cells. Their diversity is astounding, from monotopic and bitopic proteins to complex polytopic transmembrane proteins, including α-helical and β-sheet structures, and lipid-anchored proteins. Each type is finely tuned to perform specific tasks, whether it's transporting molecules, transmitting signals, or maintaining cellular integrity. Given their critical roles, it's no surprise that membrane proteins are the targets for over 60% of current therapeutic drugs. However, their complex structures and dynamic nature make them notoriously difficult to study and manipulate in the lab. • Monotopic and Bitopic Proteins: Engage with one or both sides of the lipid bilayer, playing pivotal roles in signaling and transport. • Polytopic Transmembrane Proteins: Spanning the membrane multiple times, these proteins are vital in forming channels and receptors, integral to cellular communication. • Lipid-Anchored Proteins: Anchored to the membrane via lipid moieties, these proteins are essential for cell signaling and interactions. 𝗦𝘁𝗮𝗿𝘁𝗶𝗻𝗴 𝘁𝗼 𝘄𝗼𝗿𝗸 𝘄𝗶𝘁𝗵 𝗺𝗲𝗺𝗯𝗿𝗮𝗻𝗲 𝗽𝗿𝗼𝘁𝗲𝗶𝗻𝘀 𝗼𝗿 𝘄𝗮𝗻𝘁 𝘁𝗼 𝘄𝗼𝗿𝗸 𝗶𝗻 𝗮 𝗻𝗮𝘁𝗶𝘃𝗲 𝗲𝗻𝘃𝗶𝗿𝗼𝗻𝗺𝗲𝗻𝘁? • Our approach ensures membrane proteins are kept in their native conformation, critical for functional assays and drug development. • At Cube Biotech, we tackle these challenges head-on with our NativeMP™ Platform. This technology is designed to solubilize and stabilize membrane proteins within their native lipid environment, preserving their natural structure and function. This means researchers can obtain more accurate data, whether they're involved in drug discovery, structural biology, or functional studies. #Biotech #MembraneProteins #ProteinResearch #DrugDiscovery #CubeBiotech

BIOVIA provides researchers with advanced, end-to-end business solutions on a single cloud-based platform, to support small molecule therapeutics design. The #3DEXPERIENCE platform also improves collaboration across cross-functional teams within the organization or among networked partners: 🧬 BIOVIA Generative Therapeutics Design – Generate ideas for which compounds to make next with #AI and #MachineLearning 🌐 BIOVIA Discovery Studio Simulation – Accelerate life sciences research with a comprehensive portfolio of validated molecular 3D #ModSim tools 🔍 BIOVIA Insight for Research – Gain insight into your research data to make fast informed decisions while collaborating with your teams 🧪 BIOVIA Materials Registration – Rapidly capture and identify any chemical or biological material 📚 BIOVIA Scientific Notebook –Transform your lab with a cloud-native ELN that takes a data-centric approach, instead of the traditional document-centric one Learn more: https://lnkd.in/gi_UkBrx. #DrugDesign #SmallMoleculeTherapeuticDesign #DigitalLab Dassault Systèmes | BIOVIA | Medidata Solutions

For the Game Changers in Biopharmaceuticals! The GenNext Team is transforming the landscape of complex protein system characterization with our state-of-the-art Fox® System. The Fox System is revolutionizing ways to study time resolved protein-protein interactions. The insights gained from time-resolved protein-protein interaction studies are invaluable in expanding our understanding of the intricate workings of biological systems and in developing new strategies for treating diseases. The Fox System simplifies identifying key changes in higher order structure (HOS) to the amino acid resolution following a protein-protein interaction! The Fox System doesn’t just capture a single snapshot but can monitor the entire evolution of protein interactions! From initiation to complex formation and finally to dissociation, the Fox System tracks these molecular networks, offering invalvuable informaiton on how proteins interact and function in biological systems. Such detailed understanding is vital for drug development, understanding disease mechanisms, and advancing our knowledge of biological processes. If you’re as excited as we are about pushing the boundaries of proteomics and unlocking new potentials in biomedical research, let’s connect and explore the possibilities together! Discover More: Interested in learning about other applications of the Fox Protein Footprinting System? Visit Literature – GenNext Technologies A big thank you to our dedicated GenNext Team for your relentless effort and innovation in advancing scientific research! #GenNext #Research #Science #ScientificResearch #Biotherapeutics #ProteinCharacterization #ResearchInnovation #HRPF #ProteinResearch #ScientificInnovation #Teamwork #ProteinStructure #StructuralBiology #Biochemistry #Proteomics #Biotechnology #Antibody #mAb