bit.bio’s Post

They write: PQ912, is currently undergoing clinic trials for the treatment of Alzheimer’s disease. We report an X-ray crystal structure of sQC complexed with PQ912, revealing that the benzimidazole makes “anchor” interactions with the active site zinc ion and catalytic triad. Structure-guided design and optimization led to a series of new benzimidazole derivatives exhibiting nanomolar inhibition for both sQC and gQC. In a MPTP-induced Parkinson’s disease (PD) mouse model, BI-43 manifested efficacy in mitigating locomotor deficits through reversing dopaminergic neuronal loss, reducing microglia, and decreasing levels of the sQC/gQC substrates, α-synuclein, and CCL2. This study not only offers structural basis and new leads for drug discovery targeting sQC/gQC but also provides evidence supporting sQC/gQC as potential targets for PD treatment.

🧬 While breakthroughs in genetics have shed light on disease origins, diagnostics hasn't gotten the recognition it deserves. The COVID-19 pandemic highlighted the critical role of rapid and accurate testing. Tune into this webinar from Clarivate to explore the exciting future of diagnostics, with guests from Lucid Diagnostics, ChromaCode, Inc., Immunexpress Inc., and Igentify. https://bit.ly/4bXRFVY #Webinar #Diagnostics #PrecisionMedicine

#genetherapy has the potential to revolutionize the way we treat many rare diseases. Hear the scientific, biosafety, clinical trial, and clinical care perspectives on this growing concern in Advarra's January 18 webinar.  #clinicalresearch #clinicaltrials #lifesciences

New in JACEP Open: Association of preclinical blood glucose with hospitalization rate and in-hospital mortality: A single-center retrospective cohort study. #FOAM, #BloodGlucose #Mortality https://buff.ly/4c235s6

Take a look at the re-vamped fibrosis page on PhenoVista's website here! https://hubs.ly/Q02sYTf20 There's a general overview of our capabilities in this disease area and a case study of a completed client project. If you don't find what you're looking for or want to discuss challenges you're facing in fibrosis R&D, shoot let's chat!

Know PK Deficiency. Join the community and start exploring resources that can help you move forward with pyruvate kinase deficiency. Check out the patient webinar series here: https://ow.ly/mVV850QLXGp #BleedingDisordersAwarenessMonth

Researchers used our Nutragen® (6mg/ml collagen) for a "3D Fibroblast Collagen Contraction Assay." This was part of a study to better understand the role of RUNX1 in the fibrotic progression of the autoimmune disease Systemic Sclerosis. Dermal fibrosis is a clinical manifestation of Systemic Sclerosis, resulting from the uncontrolled deposition of extracellular matrix. This study is the first to demonstrate a potential role for RUNX1 in the pathogenesis of Systemic Sclerosis Dermal Fibrosis. Read the full publication here: https://lnkd.in/e8pCyNkk #cellculture #collagen #3D

In patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis, utilizing a computational phenotype (i.e., an electronic algorithm) for identifying disease relapse has demonstrated strong performance in retrospect. This was based on findings from individuals enrolled in the Rare Kidney Disease Registry and Biobank, with the results published in the journal RMD Open. Read more: https://brnw.ch/21wJJr3 #RareDisease

It's the last day at #ADPD2024 Lisbon! Are you in need of defined, functional, consistent and scalable human iPSC-derived cells to model neurodegenerative disease in vitro? Then, you need to talk to our scientists at booth #56 about how opti-ox™ powered ioCells™ can support your research and drug discovery. Not at AD/PD? Discover below how our ioDisease Model Cells™ can provide a physiologically relevant alternative to animal models. Explore how easily they can be paired with genetically matched controls from our ioWild Type Cells™ portfolio. Learn about our Alzheimer’s and Parkinson’s disease models: https://hubs.ly/Q02nqLMw0 #research #DrugDiscovery #AlzheimersDisease #ParkinsonsDisease #science #data #optiox #ioCells #ioDiseaseModelCells #microglia #HTS #ADPD #ADPD24

Flowchart integrating screening, diagnosis, and management of BKPyV replication in kidney transplant recipients You can enhance this flowchart by referencing Table 6 and 7 available in the following link: https://lnkd.in/eg7fi5RH