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Our researchers along with St. Jude Children's Research Hospital - ALSAC and the Children's Oncology Group announced new research today that underscores a significant paradigm shift in the understanding of T-lineage acute lymphoblastic leukemia (T-ALL), an aggressive and high-risk form of cancer. For the first time, they now understand the disease as one driven by genetic changes in non-coding portions of our DNA. “These findings offer a strong a roadmap for improving patient outcomes and curing more children and adults with T-ALL,” said David Teachey, MD, an attending physician and researcher at CHOP and the study's co-author. The collaborative research, supported by the Gabriella Miller Kids First Data Resource Center and National Institutes of Health Common Fund, was published today in the journal Nature. Learn more at: http://ms.spr.ly/6048lqgxu.

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