BMG LABTECH’s Post

Cellular models of neurodegenerative diseases play an integral role in preclinical drug discovery, and safety studies. Patient iPSC-derived dopamine neurons along with Multi-Electrode Array (MEA) assay provide a useful platform to investigate functional phenotypes both at the individual neuron and network levels. CRL now offers testing of small molecules aimed at reversing pathophysiology linked with cellular models of neurodegenerative diseases. For more details contact our client service https://lnkd.in/eGbNJsNC or connect with our specialists Amit Kumar Chouhan, PhD, Eddie Burns and Dario Magnani #CharlesRiver #drugdevelopment #Pharmacology #neuroscience #drugdiscovery #neurology #neurodegeneration #parkinsonsdisease Follow us at Discovery | Charles River

Is the pathogenesis of Parkinson’s disease rooted in early neurodevelopmental defects? Congratulations to Isabel Rosety, Alise Žagare, Jens Schwamborn, and their team, for the important paper using patient-specific midbrain #organoids carrying a heterozygous GBA-N370S mutation in the GBA1gene to explore the pathophysiology of Parkinson’s disease and suggest the potential for new therapeutic approaches. Visit our website to learn more and discover how the team used Axion’s #MaestroMEA platform to perform complex electrophysiological experiments on the 3D organoids with no labels, dyes, or complicated steps. 📝https://bit.ly/4bqlv63 #neuroscience #stemcells #parkinsonsresearch #biotech

Just Published: Our new Lab Note on performing Calcium Flux assays with our new iCell Sensory Neurons. Let me know if you want to discuss how our iCell Sensory Neurons can help your pain research

Beautiful introduction! Looking forward to learn from rest of the videos in this series.

New findings from a study comparing normal brain samples to those from patients with ALS reveal important insights into the disease. The study utilized the new HTRF Total Ataxin 2 and the Mutant Ataxin 2 Detection Kits to analyze protein samples. Results showed that the Ataxin 2 protein was more highly expressed in the ALS patient sample, with a high aggregation rate. Notably, the mutant form of the protein was only detectable in the ALS patient sample, and a disaggregation step resulted in a positive assay signal. These findings provide a better understanding of the role of Ataxin 2 in ALS and could lead to new approaches for treating the disease. Want to learn more about HTRF or the study's methodology, check out the application note "Best practices for analyzing brain samples with HTRF". #ALS #neuroscience #revvity

In this paper, we explored the effects of a synthetic steroid, pregnanolone glutamate (PAG), and its metabolites on the brain and behavior. By identifying these metabolites in rats and investigating their impact on neurotransmitter receptors in neurons, along with studying their effects on the behavior of zebrafish, we observed that these compounds can influence receptors and impact behavior. For more details, we encourage you to check our paper. https://lnkd.in/dDBPg9ic #neuroscience #behavioralscience #precisionmedicine #pharmacology #zebrafish

The Kariya team is pleased to announce the publication of our CSO’s (Christian Hölscher) latest review in Neuropharmacology entitled “Glucagon-like peptide-1 class drugs show clear protective effects in Parkinson’s and Alzheimer’s disease clinical trials: A revolution in the making?”  The article summarizes the promising clinical results in the field and highlights emerging treatment strategies for PD and for AD. The future looks bright! https://lnkd.in/dZvAeukJ #endparkinsonsdisease #cureparkinsonsdisease #parkinsonsresearch #parkinsonsdisease #movementdisorders #patientsarewaiting #hope #neuroscience #CNS #onestepcloser 

🧠Migraine is among the most common neurological disorders. Two independent neuropeptides have received significant attention for their role in migraine pathogenesis: calcitonin gene-related peptide (CGRP) and pituitary adenylate cyclase-activating polypeptide (PACAP). Whilst glycerine trinitrate (GTN) had commonly been used to induce migraine preclinically by increasing CGRP production, testing drugs with alternative inducers can greatly improve the understanding of compound effects in several pathways involved in migraine pathogenesis. 🔹 Reach out to our BD team today to find out more about our pain models or discuss preclinical collaborations: https://lnkd.in/edFKh9iM #migraine #neuroscience #painmodels #cns

⚡️ 𝗔𝗘𝗗 𝗿𝗲𝗳𝗲𝗿𝗲𝗻𝗰𝗲 𝗰𝗼𝗺𝗽𝗼𝘂𝗻𝗱 𝘀𝘁𝘂𝗱𝘆 𝘀𝗲𝗿𝗶𝗲𝘀: #2 - 𝐏𝐞𝐧𝐭𝐲𝐥𝐞𝐧𝐞𝐭𝐞𝐭𝐫𝐚𝐳𝐨𝐥𝐞 (𝐏𝐓𝐙) At Neuroservices-Alliance, we are experts in assessing the effects of potential antiepileptic drugs (AEDs). PTZ is a critical compound used to induce seizures in preclinical models, providing essential insights for epilepsy research. Our findings reveal that PTZ decreases epileptiform discharge (ED) rate while increasing ED amplitude, making it invaluable for understanding seizure mechanisms and evaluating AED efficacy. 🔎 Interested in how we can enhance your AED research? Reach out to us: contact@neuroservices-alliance.com 🔗 Discover more in our detailed article: https://lnkd.in/d5gq5emb   #Epilepsy #Neuroscience #CNS #Research #drugdiscovery #PTZ #AED #Research

Using EV-mediated delivery of exogenous GABA to control epileptic seizures: Dinesh Upadhya at Kasturba Medical College, Manipal and collaborators investigated the hypothesis of delivering exogenous GABA directly to the brain via cell-specific extracellular vesicles to assess their ability to control seizures in a kainate-induced rat model of temporal lobe epilepsy https://lnkd.in/e3Z8dfeE They discovered that administering extracellular vesicles containing GABA from GABAergic interneurons and medial ganglionic eminence cells significantly decreased overall seizures, stage V seizures, and total seizure duration. An article also authored by Abhijna Ballal, Shivakumar Reddy, DIVYA CHANDRAN, Sumukha Hegde, Raghavendra Upadhya, Praveen Kumar S E, Smita Shenoy and Vasudha Devi #extracellularvesicles #exosomes #epilepsy #bioengineering #neurosciences #Vesiculab