Boston Children's Hospital’s Post

UC San Diego Institute for Network Medicine (iNetMed) grew immensely yesterday as it got a #shot of #innovative #technologies to support #quantitative cell analyses to its existing dynamic #Centers: #PreCSN (Precision Computational Systems Network), HUMANOID: Human Organoid Center of Research Excellence (CoRE) and #ConCISE (Consortium for Cell Inspired Systems Engineering). This means that programs within the Institute [e.g., #organoid models, #cellsystems, programs in #computational #immunology and #cancertherapeutics, #precision #drugdiscovery, etc.] can now #quantify #biology with #precision and #measure the #immeasurable. The Agilent Center of Excellence in Cellular Intelligence includes a complete and modern suite of cell analyses platforms that reveal cell #fate, #state, and #trait through measurable #insights across scales. These insights are expected to unlock some of the most compelling secrets that are of foundational importance. It also brings pre- and postdoctoral #fellowships to further training and education of the next generation in modern #cellbiology. What an #incredible #timing and #direction of growth!

Learn more about all the fascinating work international graduate students are doing here at URI!

Dive into the future of science with our latest article, where we spotlight the trailblazers on the brink of Nobel recognition in Chemistry. These visionaries, working across biotech, neuroscience, and materials science, are not just advancing their fields—they're crafting the solutions to some of today's most pressing challenges and paving the way for a better tomorrow. From revolutionizing healthcare to redefining our understanding of the natural world, their work promises to transform our lives in profound ways. Join us in exploring the groundbreaking innovations that could shape the future. Discover how these potential Nobel Laureates are making history, one discovery at a time. Read here: https://buff.ly/42r2egT #Innovation #NobelLaureates #FutureOfScience #BiotechRevolution

Dive into the future of science with our latest article, where we spotlight the trailblazers on the brink of Nobel recognition in Chemistry. These visionaries, working across biotech, neuroscience, and materials science, are not just advancing their fields—they're crafting the solutions to some of today's most pressing challenges and paving the way for a better tomorrow. From revolutionizing healthcare to redefining our understanding of the natural world, their work promises to transform our lives in profound ways. Join us in exploring the groundbreaking innovations that could shape the future. Discover how these potential Nobel Laureates are making history, one discovery at a time. Read here: https://buff.ly/42r2egT #Innovation #NobelLaureates #FutureOfScience #BiotechRevolution

Notable Black Innovators: Alice Augusta Ball Alice Augusta Ball was a female African American scientist and innovator. She was born in 1892, in Seattle, Washington. Alice developed the "Ball Method" - a groundbreaking treatment for leprosy in its time. Alice earned a bachelor's degree in pharmaceutical chemistry in 1912 and a second bachelor's degree in the science of pharmacy in 1914 at the University of Washington. Alice got her master's degree in chemistry at the College of Hawaii. Her thesis focused on the chemical properties of the Kava plant (Piper methysticum), which was used to treat various ailments. In 1915, she became the first woman and the first African American to graduate with a master's degree from the College of Hawaii. She was also the university's first African American and female chemistry professor. Alice's work caught the attention of Dr. Harry T. Hollmann, an Acting Assistant Surgeon at the Leprosy Investigation Station of the U.S. Public Health Service in Hawaii. He sought her expertise to study the chemical properties of chaulmoogra oil, the best available treatment for leprosy at the time. However, the oil's application methods were problematic—it was too sticky for topical use, caused blisters when injected, and induced vomiting when ingested. At just 23, Alice developed the "Ball Method," a technique that made chaulmoogra oil injectable and water-soluble. She saponified the fatty acids to form chaulmoogric acid, then transformed it into ethyl ester, retaining the oil's therapeutic properties while making it more stable for injection. This innovation provided a more effective treatment for leprosy, allowing patients to be discharged from hospitals. Tragically, she died in 1916, at the age of 24. Her death was initially attributed to chlorine poisoning from a laboratory accident, though her death certificate was later altered to cite tuberculosis. Alice's work went unrecognized for many years. However, in 1922, Dr. Hollmann published a paper acknowledging Alice's original work. #BlackScientist #InnovativeMind #ScienceTrailblazer #DiverseInnovation #STEMLeader #InnovativeScientist #DiversityInScience #TrailblazingScientist #ScientificInnovation #BlackExcellence #ScientificInnovation #DiverseGenius #STEMTrailblazer #Innovation #Computing #History #Pioneers #blackhistorymatters #inventions #inventor #innovation #engineering #Technology #STEM #Inspiration #techinnovation #InnovativeMind #PioneeringResearch #EmpoweredScientist #BreakingBarriers #FutureLeader #InspiringChange #InnovativeResearcher #BlackInnovation #SciencePioneer #techinnovation #workskills #multiplication #collegeapps #collegestudents #africanamerican #africa #black

🎉 𝐏𝐡𝐃𝐯𝐞𝐫𝐬𝐚𝐫𝐲! 𝐀𝐧𝐧𝐮𝐚𝐥 𝐮𝐩𝐝𝐚𝐭𝐞 – 𝐃𝐂6 – 𝐒𝐮𝐫𝐞𝐬𝐡 𝐑𝐨𝐡𝐚𝐧 “Time moves in one direction, memory in another.” – William Gibson I believe that the above quote clearly captures the essence of how fast the first year of my doctoral studies flew by along with the creation of countless memories. From moving into an empty house in a small town in the middle of Germany to being able to call Göttingen “my home”, I have come a long way. From struggling to assemble a bed to actually being able to host my mother at my place for two months, I have come a long way. It has truly been a pleasure being part of a #European Union consortium and getting to know colleagues who are working on similar (yet different) doctoral projects. Our consortium events at Graz, Groningen and Gothenburg (funny that the names of all these cities start with a “G” 😊) have been very fruitful in terms of knowledge acquisition and building contacts. I also hosted Lilla Gal (DC7) for a secondment in Göttingen where we managed to generate some promising structural data corresponding to her #acyltransferases. I have been working with an evolved variant of 4-oxalocrotonate tautomerase (4-OT) and was able to successfully solve the structure of this #enzyme in complex with a substrate. (Looking at beautiful deep red protein crystals is surely another amazing aspect of working with this system 😊). I am currently working on #crystallization of this enzyme in order to arrest another intermediate or the final product in the active site of the enzyme. Structural studies of other variants of 4-OT are also underway. Looking forward to more scientific updates, secondments, conferences and fun events in the next part of my PhD. Cheers! – Suresh Rohan (You can see me sitting at my desk with the screensaver of my computer set to a representation of the crystal structure solved by me!!) #PhDversary #PhDJourney #Anniversary #Biocatalysis #BiodeCCodiNNgDN #MSCA #HorizonEU

🤩 Excited to introduce Marie Gérus-Durand, our first French speaker at this year's JMP Discovery Summit in Manchester! 🧬 With a PhD in Molecular and Cellular Biology, Marie honed her expertise working at Oxford University (UK) and CNRS (Montpellier, France). As Principal Scientist/Validation Engineer at Cerba Research, she is at the forefront of the development and validation of immunohistochemistry protocols for clinical trials, ensuring that they meet stringent regulatory standards. 📽️ In her presentation 𝗖𝘂𝘁𝘁𝗶𝗻𝗴 𝗖𝗼𝘀𝘁𝘀, 𝗘𝗹𝗲𝘃𝗮𝘁𝗶𝗻𝗴 𝗤𝘂𝗮𝗹𝗶𝘁𝘆: 𝗧𝗵𝗲 𝗶𝗺𝗽𝗮𝗰𝘁 𝗼𝗳 𝗗𝗢𝗘 𝗼𝗻 𝗰𝗹𝗶𝗻𝗶𝗰𝗮𝗹 𝗶𝗺𝗺𝘂𝗻𝗼𝗵𝗶𝘀𝘁𝗼𝗰𝗵𝗲𝗺𝗶𝘀𝘁𝗿𝘆 𝗽𝗿𝗼𝘁𝗼𝗰𝗼𝗹𝘀, Marie highlighted the fact that the conventional OFAT approach (one factor at a time) is no longer adequate in the face of demanding requirements. Under Marie's leadership, Cerba Research is now taking a more innovative approach to protocol development using Design of Experiments (DOE) methodologies, aimed at improving efficiency and reducing costs without compromising quality. 🏆I particularly appreciate Marie's conclusion on the DoE approach, which can be summed up by Steve Jobs' famous phrase: 𝗦𝘁𝗮𝗿𝘁 𝘀𝗺𝗮𝗹𝗹, 𝗧𝗵𝗶𝗻𝗸 𝗕𝗶𝗴 - don't hesitate to embark on the DoE adventure by starting small in order to convince (your manager, in her case), a DoE that can later be scaled up to face bigger challenges. 😉 To find all my previous posts and follow JMP news in France, subscribe to my hastag: #JaiMonPass4JMP #JMP #JMPDiscoverySummit #DiscoverySummitEurope #Immunohistochemistry #ClinicalTrials #DOE

Dive into the future of science with our latest article, where we spotlight the trailblazers on the brink of Nobel recognition in Chemistry. These visionaries, working across biotech, neuroscience, and materials science, are not just advancing their fields—they're crafting the solutions to some of today's most pressing challenges and paving the way for a better tomorrow. From revolutionizing healthcare to redefining our understanding of the natural world, their work promises to transform our lives in profound ways. Join us in exploring the groundbreaking innovations that could shape the future. Discover how these potential Nobel Laureates are making history, one discovery at a time. Read here: https://buff.ly/42r2egT #Innovation #NobelLaureates #FutureOfScience #BiotechRevolution

Congratulations to Gert-Jan Hassing for successfully defending his PhD thesis entitled 'Feasibility of interpreting blinded pharmacodynamic data - normal variations in healthy subjects' on the 23rd of April! Read more here: https://lnkd.in/evvE-TcU

Good news! My first publication stemming from my postdoctoral tenure at Eberl's lab, University of Zurich, has been published in npj Biofilms and Microbiomes! 🎉 Check out the publication at https://lnkd.in/eeR2R7iG I'm thrilled to share that this research was a collaborative effort with Dr. Eleonora Secchi from ETH Zurich and Prof. Masanori Toyofuku from the University of Tsukuba. In this work, we unveil, for the first time, the significant role of prophage endolysins in the formation of biofilm streamers by using Burkholderia cenocepacia H111 as a model bacterium. #genotoxicstress #biofilms