Broad Institute of MIT and Harvard’s Post

A new study published in Nature Metabolism titled “Longitudinal Serum Proteome Mapping Reveals Biomarkers for Healthy Ageing and Related Cardiometabolic Diseases” provides valuable insights into the biological mechanisms of ageing and age-associated diseases. This longitudinal study analyzed 7,565 serum samples from a cohort of 3,796 middle-aged and elderly adults over a 9-year follow-up period. By incorporating deep phenotyping data, researchers identified: 🧬 86 ageing-related proteins, linked to 32 clinical traits and the incidence of 14 chronic diseases. 🤖 A novel Proteomic Healthy Ageing Score (PHAS), developed using machine learning, which predicts the long-term risk of several cardiometabolic diseases. 🌱 The gut microbiota as a modifiable factor influencing the PHAS, suggesting potential interventions to support healthy ageing. The study highlights the close association between ageing-related proteins, health status, and disease risk, particularly for cardiometabolic health. These findings offer critical biomarkers and therapeutic targets for promoting healthier ageing. #HealthyAgeing #Proteomics #CardiometabolicHealth #AgeingBiomarkers #MachineLearning #GutMicrobiota #ChronicDisease #NatureMetabolism #ScientificResearch

New Insights into Neurodegenerative Diseases (NDD): The Role of Gut Microbiome 🧪🦠 A recent study presented at the American Society for Microbiology annual meeting sheds light on the connection between gut microbiome and Neurodegenerative Diseases (NDD). Researchers from Netellis, the University of Tennessee at Knoxville, and the University of North Carolina at Chapel Hill identified the bacterial metabolite DHPS as a potential missing link in understanding how gut microbes influence NDDs through sulfur metabolism pathways. This discovery brings another brick in our quest to untangle the intricate relationship between our gut and brain. Let's imagine a future where NDD prevention and treatment could be revolutionized through the management of gut health and innovative microbiotherapeutic interventions. #NeurodegenerativeDiseases #GutMicrobiome #HealthInnovation Read more : https://lnkd.in/drrnK_up

#COVID #Epigenetics #Predisposition #AutoimmuneDiseases #CardiometabolicDiseases #Therapeutic #PersonalizedMedicine 🛑 Epigenetic dysregulation is key in the pathogenesis of autoimmune diseases (ADs) and cardiometabolic diseases (CMDs) like T2DM and CVDs. It mediates the interplay between environmental triggers and genetic factors, leading to AD development. 🛑 Defined as heritable changes without DNA alterations, epigenetic traits involve mechanisms such as DNA methylation, histone modifications, and noncoding RNAs. Environmental triggers like diet, hormones, and infection, induce oxidative stress contributing to ADs and CMDs. 🛑 Epigenetic modifications impact CMDs through pathways like inflammation, vascular dysfunction, and insulin resistance, making them potential therapeutic targets. Inflammatory environments worsen CMD prognosis, prompting epigenetic changes and increasing susceptibility to other metabolic diseases. 🛑 Understanding inflammatory processes and epigenetic modifications in CMDs is crucial for personalized medicine and predicting outcomes, particularly in young individuals. Obesity influences gene expression, immune system, and chronic inflammation, promoting CMD development. 🛑 Metabolic disruptions may lead to insulin resistance, T2DM, CVDs, kidney disease, and related comorbidities. Cardiometabolic risks involve the interplay of metabolism and the immune system, inducing epigenetic changes that impact disease development. 🛑 This review highlights epigenetic modifications and inflammatory processes in CMDs, shedding light on therapeutic interventions. Stay informed to improve personalized medicine strategies and enhance disease prediction for better patient outcomes. #Research #Healthcare #Medicine #Inflammation #Genetics #PrecisionMedicine More Information: https://lnkd.in/g27Frguz https://lnkd.in/ggP_iwmZ

MIGRAINE HEADACHES CAUSES, TREATMENTS, and POSSIBLE CURES My friends I just published Migraine paper to the internet at below link. Please send it to anyone you know that suffers migraines. https://lnkd.in/g_PQWjxw As some might recall, I am purposely disengaging from 40 years of cyber warfare and combat execution and I am building a Precision Medicine Company. I have extensively studied and attended courses at Harvard Medical School and University of Geneva as part of my preparation. I have gained and started executing on my rapidly growing expertise. My fundamental goals are to teach and mentor as many as I can about Precision Medicine, Enable advanced healing, and make genome and advance immunologic therapies inexpensive enough that all people can afford to use advanced medicine to heal. While I am building my knowledge and team and waiting for investors to arrive, I am personally writing 100 short papers on critical diseases as a public service and a way to help people and families understand beyond what they are told by their doctors in short doctor visits. In the near future, I hope to ask for volunteers to write these papers. My goal is paper is no longer than 25 pages. You can see my other medical and cyber writings at this link. (99+) Bill Ross | The Catholic University of America - Academia.edu I also hope to make some revenue to keep us moving forward. I believe we need 5 million to start up with staff, building and equipment. I have built several huge cyber architectures and in essence businesses. Ross Precision Medicine and Research (RPMR) offers this document as a foundational information source concerning Migraine Headaches. We will make the descriptions of treatments as simple as possible. We encourage you to search core and established medical sites for additional information. Please see a core list of these links within this document. RPMR has captured this information in one location as it is in the first phase of learning if someone is sick, diagnosed, and afraid by a disease that a soul most needs knowledge, help, and support. This document is not designed to be prescriptive and directional. We are not authorized to provide those services. All people need to work with their doctors to define and implement a personal migraine disease treatment. Migraine attacks remains a formidable challenge, but advances in precision medicine, genomics, cellular therapies, and phage therapies offer hope for more effective treatments and potential cures. As research continues to expand our understanding of migraines at the molecular level, the development of tailored therapies and personalized medicine approaches becomes increasingly promising. Collaborative efforts between clinicians, researchers, and pharmaceutical companies are crucial in the ongoing fight against migraines. Dedicated to my daughter. Migraine Headache Causes, Treatments, and Possible Cures User Guide academia.edu

bioRxiv, Dec 2024 A study led by Prof. Vadim Gladyshev from Harvard Medical School utilizing Olink Proteomics dataset of the UK Biobank cohort, shows that individual #protein levels can predict the #disease state of organs better than organ-specific machine learning models trained on #aging or #mortality, and better than #metabolites. The study identified a compact panel of 21 key #proteins, that can reliably predict #organ deterioration and disease. These proteins offer a cost-effective and practical approach for assessing organ health, while also providing insight into disease risk across multiple organs. The findings highlight the potential of plasma #proteomics in disease prediction and underscore the need for further exploration of protein-based #diagnostics in both #clinical and research settings.  Title: "A compact protein panel for organ-specific age and chronic disease prediction" The current study utilized #Olink Explore data measuring 2,897 proteins from ~50,000 participants from the UK Biobank. • With the exception of brain-related diseases, individual protein levels often match or surpass the predictive power of elaborate clocks trained on #chronological age or mortality risk. Certain proteins effectively predict multiple diseases affecting specific organs. • In most cases, proteins predict diseases better than #polygenic risk scores, and novel associations between human plasma protein levels and diseases were revealed, including: ^ LAMP3 and COPD, CHHR2 and liver disease ^ FAMC3 and kidney disease, ^ TMED1 and #gout • #Olink custom Focus panel of 21 protein #biomarkers was created in order to reveal the health state of the six #organs associated with major age-related diseases. • The Focus panel predicts common age-related diseases better than established blood panels and aging models, including: ^ liver #cirrhosis and #fibrosis ^ #dementia, ^ #kidney failure, and ^ Type II #diabetes Through its vast coverage of age-related diseases, the Focus compact panel offers a cost-effective alternative to full-scale #proteomic analyses, making it a prime candidate for the non-invasive clinical detection and management of numerous age-related diseases simultaneously. #Aging #Immunology #pathology #diagnostics #omics #machinelearning

"A compact protein panel for organ-specific age and chronic disease prediction". 21 protein panel predicts organ disease state better than machine learning models and metabolites. If you aren't working with plasma proteins you should be.

Diabetic kidney disease (DKD) is a common complication of diabetes and obesity, and lacks effective treatments. Ayshwarya Subramanian, Katherine Vernon, Yiming Zhou, Anna Greka, MD, PhD, and colleagues analyzed single-cell transcriptomic profiles from DKD patients and two DKD mouse models at multiple time points during disease progression. In Cell Reports, they describe an expanding population of macrophages expressing high levels of TREM2 in mice fed a high-fat diet and show that human diabetic and obese kidney tissue harbored higher levels of TREM2 macrophages. Deleting Trem2 in mice promoted kidney injury after exposure to a high-fat diet. These macrophages could be a point of intervention for DKD. #BroadInstitute #Science #ScienceNews #Research #ScientificResearch

Join us at the A4M SPRING CONFERENCE May 4-5! SURVIVING TO THRIVING IN THE 21ST CENTURY! Visit Cell Life USA at booth 1002! The emergence of the COVID-19 pandemic has starkly illuminated the potential havoc that can be wrought by a single viral pathogen when exploiting comorbidities stemming from metabolic dysfunction. This crisis serves as a poignant reminder of the pressing necessity to address the fundamental issues contributing to metabolic dysfunction, especially among the younger demographic, who would otherwise face heightened vulnerability to both chronic and infectious diseases. Metabolic diseases, contributing significantly to leading causes of preventable and premature deaths such as ischemic heart disease, stroke, various cancers (breast, prostate, colorectal), obesity, type 2 diabetes, and low bone mineral density, are influenced by a multitude of factors. #antiaging #menshealth #physique #women #doctors #homeopathic #alternativemedicine #body #biology #naturopath #A4M #covi̇d19 #disease #metabolic

This research demonstrates that a #ketogenic diet has significant immunomodulatory effects, particularly in mitigating experimental autoimmune uveitis (EAU) in mice. The KD rebalances the immune response by increasing regulatory T cells (Tregs) and decreasing inflammatory T helper 17 (Th17) cells in both lymph nodes and the retina. This dietary intervention downregulates pro-inflammatory genes and pathways, while enhancing anti-inflammatory and regulatory pathways such as TGF-β signaling. The KD also reduces immune cell infiltration and inflammation in the retina, effectively alleviating EAU severity. These findings suggest that the KD holds potential as a therapeutic approach for autoimmune diseases, including uveitis. Further research is needed to explore its clinical applicability and mechanisms. Full text: https://lnkd.in/dMZAX8Vp #ketodiet #ketogenicdiet #keto #chetogenica #dietachetogenica

MIGRAINE HEADACHES CAUSES, TREATMENTS, and POSSIBLE CURES My friends I just published Migraine paper I created to the internet at below link. Please send it to anyone you know that suffers migraines. https://lnkd.in/g_PQWjxw As some might recall, I am purposely disengaging from 40 years of cyber warfare and combat execution and I am building a Precision Medicine Company. I have extensively studied and attended courses at Harvard Medical School and University of Geneva as part of my preparation. I have gained and started executing on my rapidly growing expertise. My fundamental goals are to teach and mentor as many as I can about Precision Medicine, Enable advanced healing, and make genome and advance immunologic therapies inexpensive enough that all people can afford to use advanced medicine to heal.  While I am building my knowledge and team and waiting for investors to arrive, I am personally writing short papers on critical diseases as a public service and a way to help people and families understand beyond what they are told by their doctors in short doctor visits.  In the near future, I hope to ask for volunteers to write these papers. My goal is paper is no longer than 25 pages. You can see my other medical and cyber writings at this link. (99+) Bill Ross | The Catholic University of America - Academia.edu  I also hope to make some revenue to keep us moving forward. I believe we need 5 million to start up with staff, building and equipment. I have built several huge cyber architectures and in essence businesses. Ross Precision Medicine and Research (RPMR) offers this document as a foundational information source concerning Migraine Headaches. We will make the descriptions of treatments as simple as possible. We encourage you to search core and established medical sites for additional information. Please see a core list of these links within this document. RPMR has captured this information in one location as it is in the first phase of learning if someone is sick, diagnosed, and afraid by a disease that a soul most needs knowledge, help, and support. This document is not designed to be prescriptive and directional. We are not authorized to provide those services. All people need to work with their doctors to define and implement a personal migraine disease treatment. Migraine attacks remains a formidable challenge, but advances in precision medicine, genomics, cellular therapies, and phage therapies offer hope for more effective treatments and potential cures. As research continues to expand our understanding of migraines at the molecular level, the development of tailored therapies and personalized medicine approaches becomes increasingly promising. Collaborative efforts between clinicians, researchers, and pharmaceutical companies are crucial in the ongoing fight against migraines. Dedicated to my daughter.