Broad Institute of MIT and Harvard’s Post

#PaperSpotlight: On November 25, 2023, researchers from Seoul National University, Chungnam National University, Gangneung-Wonju National University, Hallym University, and Konkuk University published a new research paper in Aging's Volume 15, Issue 22, entitled, “Tat-heat shock protein 10 ameliorates age-related phenotypes by facilitating neuronal plasticity and reducing age-related genes in the hippocampus.” “In the present study, we investigated the effects of HSP10 on hippocampal function in both adult and aged mice.” #PressRelease: https://lnkd.in/evuZvg7w #heatshockproteins #aging #hippocampus #memory #neurogenesis #agingresearch #openaccess #peerreviewed #medEd#OA

🧠A pioneering study reveals differences in gut #microbiota between men and women with ischemic #stroke. 📰The study, published in the European Journal of Neurology, was carried out within the framework of the Maestro project, awarded to Dr. Israel Fernández-Cadenas, head of this research group, by the Instituto de Salud Carlos III. 🔬The researchers found a greater diversity of species in men and differences in the Fusobacteriaceae family in women, suggesting that these patterns could influence the risk and manifestation of the disease. 🗣️According to Dr. Miquel Lledós, from the Pharmacogenomics and Neurovascular Genetics Group at IR Sant Pau and principal researcher of the study, "the vast majority of microbiota #research carried out in stroke does not look at microbial species. We wanted to work with more specific techniques that allow us to study microbial species, which, in the end, are the most important". 🧬The study used comprehensive metagenomic sequencing techniques to study the microbial species of the gut microbiota in 89 patients with ischaemic stroke, comparing them with a control group of 12 healthy people. 📸 Dr. Israel Fernandez & Dr. Miquel Lledós Hospital de la Santa Creu i Sant Pau https://lnkd.in/g6u6cxYp

🪰 "Aneuploidy-induced cellular behaviors: Insights from Drosophila", out in Develomental Cell👇 ✍️ Jery Joy, Elena Fusari & Marco Milán ✅ Over the last century, Drosophila has provided a valuable system for studying the consequences of systemic aneuploidies. More recently, it has contributed to the identification and molecular dissection of aneuploidy-induced cellular behaviors and their impact at the tissue and organismal levels. ✅ In this perspective, authors review this active field of research, first by comparing knowledge from yeast, mouse, and human cells, then by highlighting the contributions of Drosophila. ✅ The aim of these discussions was to further our understanding of the functional interplay between aneuploidy, cell physiology, and tissue homeostasis in human development and disease. ➡️ shorturl.at/bilpO 📌https://lnkd.in/dXcGyv_x Institució Catalana de Recerca i Estudis Avançats, ICREA ICERCA - Centres de Recerca de Catalunya Barcelona Institute of Science and Technology (BIST) Parc Científic de Barcelona #IRBScience #aneuploidy #drosophila #research #senescence

Good quick read on modeling in cardiovascular physiology and different views on what controls blood circulation https://lnkd.in/e8gYBdRa

#TrendingWithImpact: On February 12, 2024, researchers Mauro Cozzolino, Yagmur Ergun, Emma Ristori, Akanksha Garg, Gizem Imamoglu, and Emre Seli from Yale School of Medicine, IVIRMA Global Research Alliance and Imperial College London published a new research paper in Aging's Volume 16, Issue 3, entitled, “Disruption of mitochondrial unfolded protein response results in telomere shortening in mouse oocytes and somatic cells.” “[...] our findings provide a preliminary understanding of how mitochondrial and telomeric aging mechanisms may interact to accelerate reproductive and somatic aging.” #PressRelease: https://lnkd.in/eiDmZ-yg #aging #telomeres #oocytes #somatic #cells #research #researchpaper #openaccess #openscience #peerreviewed #journal #publication #meded

In a previous retrospective study using postmortem human brain tissues, Mohammad Golam Sabbir, Benedict C. Albensi, et al. demonstrated that loss of Cholinergic Receptor Muscarinic 1 (CHRM1) in the temporal cortex of a subset of #Alzheimers patients was associated with poor survival, whereas similar loss in the hippocampus showed no such association. Mitochondrial dysfunction underlies #AlzheimersDisease pathogenesis. The objective of this study was to investigate the mechanistic basis of their findings. Learn More in Frontiers in Cell and Developmental Biology https://lnkd.in/dTHJ2AZU Hippocampal versus cortical deletion of cholinergic receptor muscarinic 1 in mice differentially affects post-translational modifications and supramolecular assembly of respiratory chain-associated proteins, mitochondrial ultrastructure, and respiration: implications in Alzheimer’s disease - Mohammad Sabbir, Mamiko Swanson, Robert Speth, Benedict Albensi, PhD, BCMAS, CRQM St. Boniface Hospital Albrechtsen Research Centre Alzo Biosciences, Inc. Canadian Centre for Agri-Food Research in Health and Medicine (CCARM) Nova Southeastern University Georgetown University University of Manitoba

The suprachiasmatic nucleus (SCN) – Such a mysterious central body clock manager... "As long as the central clock is communicating with a peripheral clock during the day, processes including DNA repair, mitochondrial activity (energy management), metabolism, and the natural cell cycle can be kept on track" #circadiansystem #bodyclock #cellularprocess #timingcontrol #chronobiology #aging

Thanks Dr Pasinetti for your reference to our new paper shown below.

The Double-Edged Sword of Aging: Cellular Phenomena in Wound Healing Cellular senescence is a common phenomenon in living organisms. In wound care, however, it appears to play a negative role, impeding the wound healing processes in older subjects. Phenomena in living tissue that are beneficial at a younger age but detrimental in old age are typically genetic, known as antagonistic pleiotropy. Yet, senescence, while not a genetic issue, still falls under the same category Level 5 wound issues. ( "regulatory issues" contrary to anatomical or physiological issues (Level 4)). This brings us to an intriguing question: How do we refer to these antagonistic cellular phenomena, like senescence and micro-fibrosis due to the resolution of inflammation, which aren't strictly genetic but have similar impacts? One possible term could be "cellular antagonistic phenomena," highlighting the cellular processes that act beneficially early in life but become problematic later on. Understanding these phenomena helps us better appreciate the complex interplay between our biology and aging. It also underscores the importance of research in developing targeted interventions to mitigate these late-life challenges. What are your thoughts on these cellular trade-offs? Have you noticed any age-related changes in healing processes? Let us discuss via the comments! #woundmedicine #science #evolution #aging #biology #woundcare #cellularphenomena

Cellular senescence is a normal biological process where cells stop dividing and enter a state of irreversible growth arrest. This process plays a crucial role in various physiological functions such as embryonic development, wound healing, and tissue repair. In normal physiology, cellular senescence helps prevent the accumulation of damaged cells and supports tissue homeostasis. Senescent cells also secrete bioactive molecules known as the senescence-associated secretory phenotype (SASP), which can influence their surrounding environment by promoting inflammation, tissue remodeling, and immune response. However, the accumulation of senescent cells over time is also associated with aging and age-related diseases. Understanding the regulation and impact of cellular senescence in normal physiology is essential for developing strategies to promote healthy aging and potentially target senescent cells in the context of age-related diseases. Long associated with aging, senescent cells can promote health and have physiological roles. Learn more in a recent Science Perspective: https://scim.ag/7WJ