Cardiometabolic Health Congress’ Post

Ophthopedia Update:An Evaluation of the Efficacy and Safety of Timolol Maleate 0.5% Microdrops Administered with the Nanodropper®: Examine if 12.5 μL timolol maleate 0.5% microdrops dispensed with the Nanodropper® Adaptor provide non-inferior intraocular pressure (IOP) reduction compared to conventional, 28 μL drops in open-angle glaucoma (OAG) and ocular hypertension (OHT) patients. #Ophthalmology #ophthotwitter #eyecare

GLP-1 receptor agonists, such as semaglutide and tirzepatide, are clearly a breakthrough in obesity treatment. However, comprehensive obesity care requires integrating these these and other therapies (medication, endoscopic, and most importantly, Bariatric surgery) with a multidisciplinary approach that defines treatment objectives, nonresponse criteria, and combination therapy strategies. We also need to incorporate nutrition, fitness, behavioral health, and other disciplines if we wish to maximize obesity care outcomes.

Something I have always found incredibly fascinating was that studies in people who underwent bariatric surgery (Roux-en-Y gastric bypass) showed that they subsequently had higher risk of developing various addictive behaviors, including alcohol use disorder and gambling. How can it be that a surgeon operates on the stomach and intestines, and as a result these changes to the person's brain can occur? But science continues to reveal that eating but also other behaviors and reward pathways may be interconnected to intestinally-derived hormonal signals (like GLP-1), all in a very complex and fascinating way. Some potentially good news come from a new study showing that semaglutide was associated with lower tabacco-cessation related health care visits, prescriptions and counseling in smokers with type 2 diabetes. This is an early indicator and more research is needed, but it might align with other pre-clinical studies we have seen on the benefits of GLP1. receptor agonists for substance use. An exciting area of research to watch!

Medical Xpress: Study compares weight gain across eight common antidepressants "Results showed that bupropion users gained the least amount of weight compared to users of other antidepressants. Bupropion users were approximately 15–20% less likely to gain a clinically significant amount of weight than those taking the most common medication, sertraline. For example, sertraline, escitalopram, and paroxetine are all selective serotonin reuptake inhibitors (SSRI), the most common type of antidepressant, but escitalopram and paroxetine were each associated with an approximate 15% higher risk of gaining a clinically significant amount of weight than sertraline in the first six months. It concludes: "Our study found that some antidepressants, like bupropion, are associated with less weight gain than others. Patients and their clinicians could consider weight gain as one reason for choosing a medication that best fits their needs." https://lnkd.in/eQaFMAd3 #pwME #MECFS #MyalgicE #MyalgicEncephalomyelitis #LongCovid #Depression #Antidepressants #WeightGain 

"Recent research indicates that individuals utilising #semaglutide injections, commonly used for weight management and type 2 #diabetes, have a quadrupled risk of developing a severe eye disorder compared to non-users. The medications in question, #Ozempic and #Wegovy, have been associated with an elevated risk of non-arteritic anterior ischemic optic neuropathy (#NAION), a rare but potentially harmful eye condition." #obesity #obesitycare #obesitymedicine #lifestylmedicine #healthcare

[Asking for opinion] Distinguished oncology & medical experts , I’d like to pick your brain regarding #rare #adverseevents associated with Fruquintinib dosage 5mg for 3rd line treatment mCRC. Patient experiences all #notable #AE as stated in the drug’s profile and both FRESCO & FRESCO-2 trials, however there’s a particular symptom which turns quite severe that the patient is put on steroids for pain relief, and the symptom is : jaw myositis under the right ear lobe. Is there any reason for this and could it be ethnicity related ? The patient profile is: - Male , asian, 60y/o. - T2DM for approx. 18 years - No genetic disease in the family - Healthy lifestyle: no alcohol, no fatty / fried / sugary foods - Prior Surgery: appendectomy due to appendicitis, partial hepatectomy due to mets I’m hoping to find new clinical data about this. Highly appreciated 🙏

Med Of The Day! 💊 Generic Name: Tranexamic Acid 🫀 Pronunciation: trah·neh·za·muhk ah·suhd Brand Name: Lysteda® Pronunciation: lie·steh·duh Class: - Antifibrinolytic Action 💪🏻: - Prevents the activation of plasminogen to plasmin, an enzyme that dissolves fibrin clots. By stabilizing clots, Tranexamic Acid is particularly useful for managing significant bleeding, such as in cases of traumatic injury, helping to reduce the risk of hemorrhage. Indications 🔍: - Severe Hemorrhage (within 3 hrs of EMS contact) Contraindications 🚫: - Hypersensitivity - Thromboembolic Disorders (PE & DVT) Precautions ⚠️: - TXA may lower the seizure threshold in patients with seizure disorders, and caution should be used in these patients. TXA may also increase the risk of cardiac events, such as myocardial infarction or arrhythmias in those with underlying cardiac conditions. TXA is primarily excreted through the kidneys, so patients with severe kidney failure may have impaired drug clearance. Dose & Route 💉: - Adults: 1 g (IV/IO) drip diluted in NS, titrated to patient response. - Peds: 10-20 mg/kg (IV/IO) drip diluted in NS, titrated to patient response. Adverse Effects 🩺: - Nausea & Vomiting - Hypotension - Pulmonary Embolism - Deep Vein Thrombosis - Seizures - Acute MI Onset & Duration ⌛: - Onset: 3-5 min. - Duration: 4-8 hrs. Pro Tip ‼️ - Ensure to give TXA through a separate IV line or adequately flush the line between medications to avoid potential interactions. Always consult local EMS protocols for guidance on co-administration. - Early administration of TXA is key, as heavy loss of blood will increase risk of hypovolemic shock and further complicate your treatment. Let me know what other meds you guys want me to cover! 📚 #paramedic #EMS #nremt #paramedicschool #Pharmacology #tranexamicacid

BYRICA 150 Pregabalin Capsules 150 MG What is Byrica 150 (Pregabalin Capsules 150 MG) used for ? Byrica 150 (Pregabalin Capsules 150 MG) is commonly used to treat nerve pain that may be associated with diabetes, herpes zoster (Shigles), or injury to the spinal cord. It is also used to treat pain from fibromyalgia. Byrica 150 (Pregabalin Capsules 150 MG) is also used in people with epilepsy to treat and prevent seizures, sometimes called convulsions. Byrica 150 (Pregabalin Capsules 150 MG) may be used for other conditions as determined by your healthcare provider. How does Byrica 150 (Pregabalin Capsules 150 MG) work (mechanism of action)? Byrica 150 (Pregabalin Capsules 150 MG) works in the central nervous system, or CNS, which includes the brain and spinal cord. Byrica 150 (Pregabalin Capsules 150 MG) may reduce the release of certain chemicals in the CNS that signal for pain. It is believed that Byrica 150 (Pregabalin Capsules 150 MG) also blocks abnormal electrical activity in the brain that causes seizures, which slows down the spread of seizures. How is Byrica 150 (Pregabalin Capsules 150 MG) supplied (dosage forms)? Byrica 150 (Pregabalin Capsules 150 MG) is available as generic dosage forms that are taken by mouth. How should I store Byrica 150 (Pregabalin Capsules 150 MG)? Byrica 150 (Pregabalin Capsules 150 MG) should be stored at room temperature, between 68 F to 77 F (20 C to 25 C). It can be exposed to temperatures between 59 F to 86 F (15 C to 30 C) for shorter periods of time, such as when transporting it. Store in a cool, dry place. Keep Byrica 150 (Pregabalin Capsules 150 MG) in its original package.

🔬 Understanding Inotropes and Vasopressors: A Quick Overview Inotropes and vasopressors are critical medications used in managing hemodynamic instability. Inotropes enhance myocardial contractility, while vasopressors constrict blood vessels to increase blood pressure. Here's a brief breakdown: Inotropes: These drugs increase the strength of the heart's contractions, improving cardiac output. Common examples include dobutamine, milrinone, and dopamine. Vasopressors: These medications act on blood vessels to increase blood pressure. They are crucial in managing conditions like septic shock and hypotension. Common vasopressors include norepinephrine, phenylephrine, and vasopressin. Understanding the indications, dosing, and potential side effects of these medications is essential for healthcare professionals in critical care settings. Dr. Jyothi Jetti, Pharm-D #Inotropes #Vasopressors #CriticalCare #Cardiology #Medicine #Healthcare #Hemodynamics #Pharmacology #MedicalEducation #EmergencyMedicine Keep learning, keep saving lives👍

📢 Katherine Saunders, MD, Intellihealth co-founder and obesity medicine expert, examines EMR data and the conversation around GLP-1 discontinuation and weight regain in the real world versus placebo-controlled trials. She cautions against misinterpreting the data, emphasizing the chronic nature of obesity and the need for long-term medical intervention. Read more in this ConscienHealth piece.