Cardiovascular Innovations and Applications’ Post

In a recent randomized trial published in JAMA, researchers explored the potential benefits of acetaminophen in sepsis management. The study involved 447 patients with sepsis accompanied by respiratory or circulatory organ failure and compared the outcomes of patients receiving acetaminophen (1 gram every six hours for five days) to those receiving a placebo. The findings revealed no significant difference in the number of days patients were alive and free of organ support between the acetaminophen and placebo groups. Interestingly, the incidence of acute respiratory distress syndrome (ARDS) was notably lower in the acetaminophen group (2% compared to 9%). These preliminary results are promising; however, further research is required to establish the routine use of acetaminophen in patients with sepsis and organ dysfunction. #SepsisResearch #CriticalCare #MedicalResearch #Acetaminophen #ClinicalTrials #JAMAPublication #OrganFailure

Knowing that the MAP is the most accurate value from an automated non-invasive blood pressure, is anyone else using a modified shock index (HR/MAP) as opposed to the standard shock index HR/SBP? This study is from 2012! 👀 "Our results show that in patients with a MSI greater than 1.3, there is an increased probability of ICU admission and death. MSI is a more important clinical predictor than blood pressure and heart rate because MSI > 1.3 indicates a hypodynamic state. Conversely, low MSI is also a predictor of increased mortality. This is commonly seen in patients with cerebrovascular diseases, chest pain and palpitations. These patients often have increased ICP and arrhythmias, which can be easily identified." https://bit.ly/3Lxu2bE

I think the bottom line of this project is that patients with LV dysfunction had comparable procedural outcomes and in hospital mortality (Impella effect?) to those with preserved LV function, yet the moment they left the hospital they had higher adjusted risk for MACCE which became significant at 90 days, driven mainly by cardiovascular death!!! (Not MI and neither repeat revasc.). While the role of PCI in patients with ischemic cardiomyopathy is still a matter of debate, these patients should have an immediate access (while they still hospitalized) to a heart failure specialist to maximize their GDMT, consider ICD and/ or CRT implantation as well as considering other therapies such as TEER. Otherwise, mortality risk is high at very early stage https://lnkd.in/dwxNKgvs

Looking for participants in Cardiovascular Health Study! A Study of Inclisiran to Prevent Cardiovascular Events in High-risk Primary Prevention Patients. Join us in investigating Inclisiran's potential in preventing cardiovascular events in high-risk individuals without prior major ASCVD events. Swipe through for eligibility criteria, inclusion, and exclusion. If you meet these criteria and are interested, contact us or visit our website to enroll! 🔬 Click here for more details! https://lnkd.in/gbREBmBJ 🩺 Medcare Pharma: Your Way to Cure Contact us: ☎️ | 1-866-4-MEDICINE 📧 | info@medcarepharma.care 🌐 | https://lnkd.in/gA9pPUVR #cardiovascularhealthstudy #clinicaltrial #clinicalresearch #medicalresearch #clinicalstudies #clinicalstudy #healthcare #medcarepharma #researchstudies

📢 The B3 study reveals groundbreaking benefits of Closed Loop Stimulation (CLS) in patients with Sinus Node Disease (SND) and indicated for dual-chamber pacing! 🧠 Did you know that CLS significantly delays subclinical AF, reducing the risk of stroke and other cardiac complications? Dr. Ennio C. L. Pisanò shared insights from the multicenter, prospective B3 study, showing the superiority of CLS versus accelerometer-based rate adaptive pacing. Key Findings: ✔ CLS reduces subclinical AF and stroke risk by 16% compared to conventional accelerometer-based pacing. ✔ CLS delays new onset of AHREs, especially those of long duration. ✔ SND patients with preserved AV conduction and no AF history benefit most from CLS pacing. ✔ CLS is a unique impedance-based myocardial contractility sensor that proves to delay the onset of Subclinical AF in patients wiht Sinus Node Disease (SND) and indicated for dual-chamber pacing. Find out more: https://ow.ly/Y9uR50RcSoE #CardiacRhythm #SinusNodeDisease #SubclinicalAF #RateAdaptive #ClosedLoopStimulation

Knowing that the MAP is the most accurate value from an automated non-invasive blood pressure, is anyone else using a modified shock index (HR/MAP) as opposed to the standard shock index HR/SBP? This study is from 2012! 👀 "Our results show that in patients with a MSI greater than 1.3, there is an increased probability of ICU admission and death. MSI is a more important clinical predictor than blood pressure and heart rate because MSI > 1.3 indicates a hypodynamic state. Conversely, low MSI is also a predictor of increased mortality. This is commonly seen in patients with cerebrovascular diseases, chest pain and palpitations. These patients often have increased ICP and arrhythmias, which can be easily identified." https://bit.ly/3Lxu2bE

How can we treat acute pain in patients with uncontrolled gout while also preventing comorbidities and addressing cardiovascular risks? Check out this brief program to hear Drs. Abdul Abdellatif and John Boston evaluate approaches to managing uncontrolled gout. They discuss clinical agents, assessing their efficacy and examining potential adverse events associated with their use. They also touch on the pathophysiology of gout, share common treatment goals, and assess recent advancements in care. Tune in for an insightful conversation about optimizing outcomes for patients with uncontrolled gout. Discover perspectives on clinical care now: https://ow.ly/cwma50QsFQG

Transesophageal echocardiographic abnormalities are common in mechanically ventilated patients with sepsis and new-onset atrial fibrillation, but only left ventricular systolic dysfunction was associated with cardiovascular events at day 28. 🔗https://zurl.co/Pfti #AIC

Development & validation of novel #MCS risk stratification tool for mortality for children supported with ventricular assist device: the Advanced Cardiac Therapies Improving Outcomes Network (ACTION) VAD score, including 4 components: 🫁 ventilation 🩸 advanced organ support: dialysis or #ECMO 🩺 diagnosis ⚖️ size (weight ≤5 kg) Patients classified into 4 classes: class 0 🟢 (4% mortality at 1 year), class 1 🟡 (16%), class 2 🟠 (21%), class 3 or higher 🔴 (42%). ACTION VADs performed well, and can be calculated easily (1 point added for each risk factor), offering useful risk stratification & prognostic information for pediatric VAD candidates. #PedsICU ASAIO Journal 🖇️ https://bit.ly/3M8MTdd

This month's issue is Emergency Department Management of Patients With Right Heart Failure. Right heart failure (RHF) can be an acute or a chronic condition that is diagnosed as being caused by or presenting with many pulmonary, cardiovascular, and chronic conditions. Recognition of RHF is essential in offering treatment for underlying etiology, treat the RHF, and avoid decompensation. Read the full issue now! https://loom.ly/l7BEMbQ