CD Genomics’ Post

Excited to share part of my postdoc work at the Kim Jensen lab at Novo Nordisk Foundation Center for Stem Cell Medicine – reNEW as a #preprint 🥳 We benchmark human colon #organoid models to IECs in vivo leveraging high sensitivity Deep Visual Proteomics in close collaboration with Frederik Post, Andreas Mund & Matthias Mann and with our clinical collaborators Herlev og Gentofte Hospital Ole Haagen Nielsen and Casper Steenholdt While we observe a robust correlation between organoids grown in vitro and IECs in vivo, organoids display high proliferation and lower functional signatures #Xenotransplantation of human organoids into the murine colon reverts these signatures, rendering them more in vivo-like This has implications for the use of xenotransplanted organoids as models to assess and dissect human epithelial phenotypes, as well as in regenerative medicine approaches Read more here: https://lnkd.in/d4tDawGE

Live-cell imaging and analysis allows scientists to study dynamic cellular events in real time to gain unique insights into biology. These techniques are in contrast to PCR, flow cytometry, and immunocytochemistry and tissue staining with antibodies, which analyze cellular events as a snapshot. Click to learn how we can help you to do more meaningful live cell analysis. #LiveCellImaging #cellbiology

Hot on the heels of our ioAstrocytes launch today, Genetic Engineering & Biotechnology News have just published an article interviewing our CEO Dr Mark Kotter about the expansion of our ioCells CNS toolkit. Read this article to discover more about the story behind our deterministic cell programming technology, opti-ox: https://hubs.ly/Q02CF1gh0 #research #DrugDiscovery #iPSC #astrocytes #ioCells #optiox

Can MALDI-MS-based imaging proteomics function as a supporting tool in a modern pathologist's workflow? Check out the recent Review article produced by our group at Università degli Studi di Milano-Bicocca, entitled "The journey towards clinical adoption of MALDI-MS-based imaging proteomics: from current challenges to future expectations" which addresses some of the recent progress made, along with the challenges still faced, in order to bring this technology closer to adoption in the context of molecular pathology. https://lnkd.in/edBnBci6 Isabella Piga #masspectrometry #moleculardiagnostics #pathology #proteomics #machinelearning

I wrote a book called 'Better Eyesight: What You and Modern Medicine Can Do to Improve Your Vision' which is available on Amazon and Kindle. 📖 👁 The book covers the latest developments in ophthalmology, such as brain implants and gene therapy, and provides detailed information on various treatments for retinal disorders, including stem cell and gene therapies, laser photocoagulation, and more. The goal is to empower individuals to take control of their vision health by offering valuable insights and resources on how to improve eyesight through lifestyle changes, nutrition, and alternative therapies. 👀

Native-state proteomics of Parvalbumin interneurons identifies unique molecular signatures and vulnerabilities to early Alzheimer’s pathology Native state proteomics of PV interneurons revealed unique molecular features of high translational and metabolic activity, and enrichment of Alzheimer’s risk genes. Early amyloid pathology exerted unique effects on mitochondria, mTOR signaling and neurotransmission in PV neurons. https://lnkd.in/ezqHyydx

Nanoscope Therapeutics Inc. is pleased to announce that Amir Singh, Ph.D. will present at the 68th Annual Biophysical Society Meeting taking place from February 10-14, 2024, at the Pennsylvania Convention Center in Philadelphia. The meeting provides a platform for researchers to share their latest discoveries and innovations in biophysics. During his presentation, Dr. Singh will delve into the biophysical characteristics of the MCO molecule (MCO-010). He will reveal the unique mechanism of action of MCO-010 while detailing its distinctive bioinformatics, molecular structure, and photosensitive properties. The presentation underscores the significance of biophysical research and its potential impact on advancing our understanding of vision restoration therapies.   Presentation details Title: Elucidating the structural and functional uniqueness of multi-characteristic opsin, a highly bioengineered, ambient-light-sensitive molecule, with broadband spectral responsiveness and fast kinetics to modulate neural activities  Date: Wednesday, February 14, 2024 Time: 10:30 a.m. ET  Location: Exhibit Hall AB  Presenter: Dr. Amir Kumar Singh   MCO-010's distinctive structure enables functions like broadband light sensitivity, high dynamic range, and rapid activation kinetics, making it promising for restoring vision in those with degenerative retinal diseases. Its ability to function in ambient lighting without external stimulation devices opens new possibilities for vision restoration. This novel optogenetic approach is a significant step toward treatments for neurological disorders involving abnormal neural circuitry activity. Samarendra Mohanty #optogenetics #genetherapy #retinitispigmentosa https://lnkd.in/geUp_VbZ

📚 PUBLICATION | Retinal #organoids grown for 26 days in 1600µm microwells #Gri3D plates to obtain 7 microtissues per well. Many genetic mutations cause dysfunction and death of rod and cone #photoreceptors (PR), the two key photosensitive cell types in the retina, leading to vision decline and often blindness. While many efforts are made to unravel mechanisms behind PR loss, no therapy exists to robustly protect photoreceptors, highlighting the need to develop improved in vitro #retinal models.   Towards that goal, scientists from EPFL and University of Lausanne - UNIL reported a tissue-engineering approach to accelerate and standardize the production of #retinalorganoids by culturing mouse embryonic stem cells in microcavities – yes, that’s one of the first publication describing #Gri3D. This is a promising system for the investigation of mechanisms of retinal development under #pathophysiological conditions, screening of neuroprotective compounds, or even providing a cellular source for clinical #transplantation👩🔬 📄 Read the full #publication here: https://lnkd.in/esD9D_zD and contact us at enquiries@sunbioscience.ch if you have any questions! #3Dcellculture #organoids #publication #biotechnology #research #invitromodel #highthroughput

Certain RNA molecules in the nerve cells in the brain last a life time without being renewed. Interested? Read more in this insightful article > https://lnkd.in/d67Dw5e4 #RNA #Microbiology

We are proud to have speakers working both on fundamental and applied research. Get ready to hear outstanding Dr. Ganna Bilousova, who will be presenting on "An Autologous iPSC-based Gene Therapy for Inherited Skin Blistering Diseases Delivered via Cell Suspension." 🔔 The abstract submission deadline has already passed, but you can still participate as a listener. We will make sure your experience is comfortable whether you join us on site or online. 🔬 Speaker Bio: Dr. Ganna Bilousova (Ph.D.) is an Associate Professor of Dermatology at the University of Colorado Anschutz Medical Campus, USA. She received her Ph.D. in Biochemistry from the University of Colorado in 2007. Dr. Bilousova's research focuses on skin and connective tissue diseases, such as Epidermolysis Bullosa and Ehlers-Danlos Syndrome, and the development of therapeutic approaches for these conditions. As Director of the Stem Cell Biobank and Disease Modelling Core at the University of Colorado, Dr Bilousova focuses on the generation and genetic engineering of induced pluripotent stem cells (iPSCs) for the research community. She collaborates with Dr. Dennis Roop and Dr. Igor Kogut in the development of iPSC-based therapies for skin diseases. We look forward to seeing you at the conference! Follow us on social media using the hashtags #BioGENext #BioGENext2024 #BiogenextConference #ScientificConference #Research #Biotech #Ukraine #GeneTherapy #iPSC #BiomedicalResearch #Innovation #Collaboration #Science #TherapyDevelopment #Conference #Biotherapy