How to build an #AAVplatform that produces higher titers and percent full #capsids Next month, join Leisha Kopp (Senior Field Applications Scientist, Mirus Bio) and Chris Brown (Senior Scientist of Process Development, ReciBioPharm) as they explore a #transfectionreagent and enhancer platform that increases both #AAVtiters and percent full capsids by 2- to 10-fold over existing technologies, regardless of #serotype, media choice, or suspension #HEKcell type. Attend to learn about: • Increasing both AAV titers and percent full capsids by 2- to 10-fold over existing technologies, regardless of serotype, media choice, or suspension HEK cell type • Case study data highlighting how a novel platform achieves high titers and percent full capsids without sacrificing efficiency • How to reduce cost per bioreactor run, and ultimately drive down cost per patient dose Register for this upcoming #webinar below:
Cell & Gene Therapy Insights’ Post
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BioInformant.com, World's Largest Publisher of Stem Cell News | Real Estate Investor | PatriotHoldings.com, Board Member, & Advisor | Former USA Rugby Player
When it comes to #bioprocess media, the company I always recommend is RoosterBio Inc. Their RoosterNourish™ is the industry's best-performing bioprocess media used for MSC expansion from R&D through clinical manufacturing. Years of formula and process optimization have increased productivity and eliminated media exchanges, which can drastically reduce your costs and expansion time by up to 60%. DID YOU KNOW that RoosterNourish media provides the same benefits to multiple cell types? • Fibroblasts • Immortalized MSCs • iPSC-derived MSCs • Autologous MSCs Learn more here: https://lnkd.in/gjnvQpmG #msc #stemcells #research #cellculture Kim Hastings
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What if you could eliminate the need for traditional blood draws? Pictor’s PictArray technology makes this possible by using advanced protein arrays in a 96-well plate, enhancing diagnostic yield from simple saliva samples. This method not only optimizes laboratory workflows but also minimizes patient discomfort. Discover how the Pictor approach is transforming diagnostics. #SalivaDiagnostics #NoMoreNeedles #AdvancedDiagnostics #PatientComfort #BioTech #ELISA
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When it comes to #bioprocess media, the company we always recommend is RoosterBio Inc. Their RoosterNourish™ is the industry's best-performing bioprocess media used for MSC expansion from R&D through clinical manufacturing. Years of formula and process optimization have increased productivity and eliminated media exchanges, which can drastically reduce your costs and expansion time by up to 60%. DID YOU KNOW that RoosterNourish media provides the same benefits to multiple cell types? • Fibroblasts • Immortalized MSCs • iPSC-derived MSCs • Autologous MSCs Learn more here: https://lnkd.in/eEE4BTuP #msc #stemcells #research #cellculture
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If you are interested in learning about the latest results of CAR-T process intensification achieved in a collaboration between #Sartorius and Qasim Rafiq lab at #UCL , led by Pierre Springuel, watch this webinar recording. #cgt #cartcelltherapy #cart #perfusion #advancedtherapies
Historically, rocking motion bioreactors have been the preferred choice for culturing CAR-T cells due to their user-friendly nature and lower capital investment. However, with the emerging trend of large-scale production in allogeneic #cartcelltherapy, there is a need to explore more suitable alternatives. In a recent study, conducted in collaboration with University College London, the possibility of culturing CAR-Ts under stirred conditions was explored and an optimized protocol was developed. The results, presented in the webinar linked below, reveal that CAR-Ts cultured in the #Ambr®250 under stirred conditions demonstrated a higher fold expansion without affecting CAR-T expression, compared to those cultured in flasks. The study also compared pre-expanding the cells for 7 vs. 3 days prior to the stirred fed-batch culture. The IQue®3 flow cytometric analysis showed that CAR-T cells pre-expanded for 3 days exhibited a less differentiated phenotype (more naïve than effector) and lower expression of exhaustion markers (CD69, PD-1). The killing capacity was evaluated using the #Incucyte® live-cell imager, showing that the shortened protocol increased the production of TNF. To further increase the final yield, a process intensification method was studied using the #MODDE®, design of experiments tool. The shortened fed-batch protocol was compared with perfusion culture. Perfusion using #4Cell®Nutri-T XF GMP medium achieved 4.5X yields compared to fed-batch cultures after 7 days. Importantly, the CAR-Ts obtained by perfusion retained ideal therapeutic characteristics such as a less differentiated, less exhausted, and less activated phenotype. The next steps include scaling up the process to 2L in the #Univessel®STR Bioreactor and automating the harvesting step using #KSep®400. Stay tuned for the results and don't hesitate to get in touch if you're interested in intensifying your #cartcelltherapy production! #CellTherapy #CAR-T #Perfusion #AdvancedTherapies #Innovation #Webinar #Sartorius https://lnkd.in/g4B67MMZ
Webinar: Optimizing perfusion parameters for intensified production of CAR-T cells |Sartorius
sartorius.com
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CEO@M2-Instruments & COO@M2-Automation | ultra low-volume dispensing from R&D to production
Perfect case study how to leverage microarrays in a microtiterplate 👌
What if you could eliminate the need for traditional blood draws? Pictor’s PictArray technology makes this possible by using advanced protein arrays in a 96-well plate, enhancing diagnostic yield from simple saliva samples. This method not only optimizes laboratory workflows but also minimizes patient discomfort. Discover how the Pictor approach is transforming diagnostics. #SalivaDiagnostics #NoMoreNeedles #AdvancedDiagnostics #PatientComfort #BioTech #ELISA
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How can we refine and de-risk drug development process and start using reliable sources in clinical trials, exponentially increasing the efficiency and effectiveness of research? Yesterday, we highlighted the challenges that the #clinicalresearch environment is currently facing, but these limitations can be overcome through innovation. ELEM virtualizes medical trials and patients using advanced mathematical models, enabling the prediction of treatment outcomes in real patient conditions. Currently, medical devices and drugs are tested without taking into account the variation and diversity of individuals… but with supercomputers, there is no limit to either the number of tests that can be done or the number of variables that can be considered, thus making the drug suitable for anyone and being able to take into account age, gender, ethnic groups and so on. ELEM is the future of medicine. Now! If you are interested in discovering our contribution to revolutionizing the clinical trial environment, send us a DM or follow this link: https://www.elem.bio. #medtech #clinicaltrials #animaltesting #EUeic
ELEM The Virtual Humans Factory
elem.bio
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Accelerate your research timelines, enhance the efficiency of your workflows, and drive groundbreaking discoveries with #QPix Insights, Molecular Devices’s latest innovation in #microbial_screening and #colony_selection. Developed collaboratively by Molecular Devices and IDBS, QPix Insights is designed to revolutionize your research workflow by providing: ✅ User-Friendly Interface: Simplifies complex data analysis for all levels of scientific personnel. ✅ AI-Powered Precision: Reduces errors and increases data reliability. ✅ Streamlined Data Integration: Integrates data from various sources for a comprehensive overview. ✅ Cost and Time Savings: Identifies the right colony faster, reducing reruns and waste. ✅ Optimized Colony Selection: Recommends the best selection criteria to improve efficiency and quality.
QPix Microbial Colony Pickers
moleculardevices.com
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Exciting news in the lab automation world! With the apricot S3 automated pipettor, RNA extraction from cell or tissue lysates in plate formats is easily accessible for all labs. Pairing the EchoLUTION extraction technology with the apricot S3 allows for increased speed and efficiency. Furthermore, the apricot S3 is revolutionizing workflows by automating the ExpressPlex HT workflow with seqWell. This automation streamlines processes, making lab work more efficient and less time-consuming. Stay ahead in the game with these cutting-edge technologies! Check out these application notes using the links below. EchoLUTION: https://lnkd.in/gNEvZWxn seqWell: https://lnkd.in/gWehXzY5 Other Partners: https://lnkd.in/gpF4cycm #LabAutomation #RNAExtraction #Innovation #Efficiency
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🌟 Judith Eschbach and Pierre Eftekhari, two of the driving forces behind our latest scientific paper, are here to share insights in a special interview! 🚀🔬 📝 Title: "Drug Upgrade: a complete methodology from old drug to new chemical entities using Nematic Protein Organization Technique." 🔗 Read the full paper here: https://lnkd.in/gFSPBxsu In this interview, Judith and Pierre take us behind the scenes of our groundbreaking research, from inception to publication. Learn about the innovative approaches, collaborative efforts, and the transformative impact on drug development programs. 🧠 Gain a unique perspective on the challenges overcome and the opportunities uncovered. Judith and Pierre shed light on how this research shaped Inoviem Scientific commitment to optimize time and resources in the entire drug discovery process of our clients with a true patient-centric approach and proprietary technologies 👇 Feel free to share your thoughts and questions in the comments. Let's continue pushing the boundaries of knowledge! #Inoviem #drugdevelopment #drugdiscovery #clinicalphases #patientcentric #technology #innovations #healthcarefuture #personalizedmedicine
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In our fast-paced, ever-evolving world, it's easy to overlook the facts that truly matter. Yet, beyond the facades, one timeless value remains the cornerstone of our success: 𝐃𝐨 𝐓𝐡𝐢𝐧𝐠𝐬 𝐑𝐢𝐠𝐡𝐭 It isn’t just about completing tasks or meeting deadlines. This core value is reflected in every action we take, understanding its impact, and consistently striving to make thoughtful and right decisions. It’s the relentless commitment to advancing medical innovation and our dedicated mission to bring impactful scientific discoveries to life through evidence-based bioprocessing solutions. With CytoHealth, the #RegenerativeMedicine bioprocessing expert, delve into the depth of science and technology. Let’s discover how each single cell can make a world of difference! #ExplorewithCytoHealth #biotechinnovation #stemcell #extracellularvesicles #exosomes
