Cell & Gene Therapy Insights’ Post

#AMCDiscoveries Neuronal swelling is a pathological feature of stroke which contributes to the formation of cytotoxic edema. Under hypoxic condition, aberrant accumulation of sodium and chloride ions inside neurons increases osmotic pressure, leading to cell volume increase. Researchers from National Neuroscience Institute (NNI) and Duke-NUS Medical School examined the role of SLC26A11 in cortical neurons during hypoxia. The in vivo effect of blocking SLC26A11 under hypoxic conditions was also further studied using a rat model of stroke reperfusion. Their findings demonstrated that SLC26A11 is a major pathway for chloride entry in stroke, contributing to neuronal swelling and inhibition of SLC26A11 could be a novel therapeutic strategy for stroke. Read more in Journal of Molecular Neurobiology, Springer Nature Group: https://bit.ly/3RGl6Fk AMC researchers involved: Wei Shunhui, Bo Chen, See Wee Low, Charlene Priscilla Poore , Yahui Gao, Ping Liao #AMRInews #research #biomedical #Singapore #NNI #DukeNUS #stroke #neuronalswelling #SingHealth #AMC Visit SingHealth Duke-NUS AM Research Institute (AMRI) at bit.ly/aboutAMRI

Last week, our Senior Director of Neurobiology, Carrie Bowen, presented a poster at the 2024 Society for Neuroscience (SfN) meeting on atai's recent discoveries of novel, selective 5-HT2A receptor agonists with non-hallucinogenic potential for treatment-resistant depression (TRD).    Up to 300 million people globally live with depression; a third of whom find no relief from current treatment options because they suffer from TRD. To address this huge unmet need, Carrie and the rest of the Discovery team are focused on identifying novel molecules using artificial intelligence and machine learning informed drug design and medicinal chemistry to discover a treatment that could, one day, have the potential to offer durable efficacy and flexible dosing options for people living with TRD.   Thanks Carrie for reminding us how cool science is!    Learn more about this program and our discovery efforts by reading Carrie's poster ⬇️  https://lnkd.in/gTi38MbK 

In the world of high resolution molecular #pathology, the possibility of impact is extremely motivating. Companies working on application development (like Resolve Biosciences) are redefining the industry. With evolving spatial technology, we will see an impact in the way samples are analyzed across various disease states. We will see an impact on our understanding of neurobiology. We will see an impact on the cell therapy engineering market. And the best part is... this is just the beginning. What are some possibilities you're excited about? #spatial #development #impact

Exciting findings from my debut research paper "Degree of differentiation impacts neurobiological signature and resistance to hypoxia of SH-SY5Y cells"! 🌟 We explored the impact of differentiation on the widely used SH-SY5Y cells, uncovering key insights: 🧠 Undifferentiated & early-stage SH-SY5Y lacked neurobiological signatures. 📈 Differentiation increased neuronal markers & synaptic puncta formation. ⏰ Longer differentiation linked to reduced hypoxia resistance. 🔬 At 3 weeks, SH-SY5Y exhibited MAP2 expression akin to hiPSC neurons, yet fewer synaptic puncta. Our results emphasize the significance of a minimum 3-week differentiation for SH-SY5Y cells to mirror hiPSC-derived neurons' neurobiological signatures and stress sensitivities. The paper is published open access and can be read via this link: https://lnkd.in/eyKwwZRV 🤝 Let's connect to dive deeper into these exciting findings! #Neuroscience #ResearchHighlights #SHSY5YCells 🌐📊

[PUBLICATION] Acyl-CoA Binding Protein for the Experimental Treatment of Anorexia 🧠 🍽️ A new study led by Chen et al. highlights the potential of acyl-CoA binding protein (ACBP) as a promising treatment option for anorexia nervosa. This eating disorder is notoriously difficult to treat, but the study demonstrates that ACBP administration can promote food intake in mouse models of stress- and chemotherapy-induced anorexia, offering a new potential therapeutic avenue. As part of this collaborative effort, Francois Mailliet and franck oury - Integrative neurobiology team at INEM - Institut Necker Enfants Malades, contributed their expertise in neuro-metabolism (molecular and histological), conducting adipose tissue analyses across various anorexia models. They were supported by the Neurobehavioral and Metabolism platform - #SFRNecker, playing a crucial role in this collaborative project. 🤝 This study exemplifies the power of multidisciplinary teamwork across leading research institutions. 🔗 https://lnkd.in/dmqh6ZG5 Université Paris Cité INSERM Inserm : Paris & Île-de-France CNRS CNRS Délégation Île-de-France Villejuif Centre de Recherche des Cordeliers Gustave Roussy Institut Imagine Greater Paris University Hospitals - AP-HP Institut Curie

Nova postagem: Genetic enhancement of learning and memory in mice - https://lnkd.in/dyh86Dm9 quest to understand the mechanisms underlying learning and memory has been one of the main focuses of neuroscience. An innovative study by Tang et al. (1999) demonstrated that genetic manipulation of the NR2B subunit of the NMDA receptor in transgenic mice resulted in a significant increase in the learning and memory capacity of these […]

Check out our new paper just published in #ScienceAdvances! We used ATAC-seq to target neuron subtypes in the brain 🧠 and show that these neurons are important for behavior like #sleep! This approach will allow improved access to sparse neurons in #neuroscience. Read the paper here ➡️ https://lnkd.in/gYzeD-bH

☑️ *READ ABSTRACT BELOW:* Part 2: The ethical or logistical inaccessibility of human fetal brain tissue has also limited direct examinations of prenatal drug effects. To circumvent these confounding factors, recent groups have begun employing induced pluripotent stem cell (iPSC)-derived brain organoid technology, which provides access to key aspects of cellular and molecular brain development, structure, and function in vitro. In this review, we endeavor to encapsulate the advancements in brain organoid culture that have enabled scientists to model and dissect the neural underpinnings and effects of OUD and POE. We hope not only to emphasize the utility of brain organoids for investigating these conditions, but also to highlight opportunities for further technical and conceptual progress. Although the application of brain organoids to this critical field of research is still in its nascent stages, understanding the neurobiology of OUD and POE via this modality will provide critical insights for improving maternal and fetal outcomes. Dwivedi I, Front Cell Neurosci. 2024 May 15;18:1403326. doi: 10.3389/fncel.2024.1403326. PMID: 38812788; PMCID: PMC11133580. #Gesundheit #Bildung #Fuehrung #Coaching #Mindset #Motivation #Gehirn #Neuroscience #Psychologie #Persoenlichkeitsentwicklung #Kindheit #KeyNoteSpeaker #Humangenetik #Biochemie #Neuroleadership #Ernaehrung #Transformation #Stress #Demografie #Gender #Age #interkulturelleKompetenz #Epigenetik #Veraenderung #EmotionaleIntelligenz #Change #Gesellschaft #Organisationsentwicklung #Philosophie #Beratung # Quantum

# 🧠 Breakthrough in Brain Research: #Magnetogenetics Revolution 🔬 Exciting developments in #neuroscience! A groundbreaking study on magnetogenetics reveals a non-invasive method to control brain circuits using magnetic fields. Here's what you need to know: 🔹 **Game-Changing Technology**: Magnetogenetics uses magnetic nanoparticles to activate specific neurons, offering precise control without invasive procedures. 🧬 **Innovative Gene Therapy**: Employs viral vectors to deliver magnetically-sensitive proteins to target neurons, enabling magnetic field responsiveness. 🏥 **Medical Impact**: Shows promise for treating: - Parkinson's disease - Depression - Obesity - Chronic pain 🐁 **Proven Results**: Preclinical studies in mice demonstrated significant improvements in Parkinson's-related movement issues. 🔮 **Future Horizons**: Researchers are exploring clinical applications for various neurological and psychiatric conditions. 👥 **Power of Collaboration**: Joint effort by Weill Cornell Medicine, The Rockefeller University, and Icahn School of Medicine at Mount Sinai. This technology marks a new era in neurology, potentially revolutionizing treatment options for millions. What are your thoughts on this advancement? #Neurotechnology #BrainScience #MedicalInnovation #Magnetogenetics #NeurologyBreakthrough #BiotechAdvancement #MedicalResearch #NeuroscienceNews --- Source: Neuroscience News