Cell & Gene by Oxford Global’s Post

Discover the latest advancemnet in genetic engineering by exploring my blog! #GeneticEngineering #BridgeRNA #GeneEditing

🧬 Optimizing Retron Gene Editors with Machine Learning Discover how high-throughput libraries and machine learning are revolutionizing retron gene editors, enhancing DNA production and genome editing efficiency! 🔬 🔑 Key Highlights: -Utilized variant libraries to test thousands of ncRNA modifications. -Machine learning model, retDNN, predicts efficient RT-DNA production. -Validated findings in yeast and human cells for broader application. 📈 Applications: Precise genome editing, molecular barcoding, custom DNA sequences, and more! 🔗 Read the full article to learn more - https://lnkd.in/g-D5fNMS #Biotechnology #GenomeEditing #MachineLearning #Bioengineering #Innovation

📍 scGIST: gene panel design for spatial transcriptomics with prioritized gene sets Yafi et al. proposed scGIST, a constrained feature selection tool that designs sc-ST panels prioritizing user-specified genes without compromising cell type detection accuracy.   Key points 📌 Consistent outperformance of the alternative methods 📌 Remarkable margins for small panel sizes (<50) 📌 Possibility to include other genes or complexes of interest ➡ More details: https://lnkd.in/e_WGJ7hQ #baylorcollegeofmedicine #spatialomics #spatialbiology #singlecellanalysis #singlecell

Researchers at the Howard Hughes Medical Institute in the United States have recently conducted an exploratory study, unveiling advanced #crispr systems within #microbial genomes. This significant discovery not only signifies the evolution of CRISPR technology but also opens new avenues for its direct #therapeutic applications in humans. The identification of these sophisticated CRISPR systems provides a pivotal opportunity to customize them for diverse gene editing applications, thereby enhancing their suitability for various therapeutic interventions. https://lnkd.in/dUWDF9Wi

CRISPR-Cas9: Revolutionizing Gene Editing 🧬✂️ Curious about CRISPR-Cas9 and its revolutionary impact on genetic research? Our in-depth blog looks into how this cutting-edge technology works, its potential applications, and the ethical considerations surrounding it. 📖 Read the blog to gain a deeper understanding of CRISPR-Cas9 and its role in the future of genetic medicine. Check it out here (https://lnkd.in/dJagW7Wa) #CRISPR #GeneticEditing #GeneGateUAE #HealthInsights #Biotechnology #BlogPost

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Introducing a Revolution in Genomic Research! Check out Cellecta's innovative study on "A Flexible and Efficient Approach for Single-Cell CRISPR Perturbation Screens." Discover how our tailored CRISPR technologies like the 10X Genomics and CROP-Seq approaches provide unparalleled insights into gene function and cellular response pathways. Explore our findings on how these technologies can be effectively utilized to dissect complex biological processes, enhancing the precision of genetic research. Step into the future of genomics with us! Learn more about our cutting-edge methods here! https://lnkd.in/gSWfABNN #Cellecta #CRISPR #SingleCellAnalysis #GenomicResearch #InnovationInScience

If you missed our webinar with Synthego last week, you can now watch the recording on demand on our website. Description In this engaging webinar with Synthego and Mission Bio, explore the revolutionary potential of CRISPR genome editing. CRISPR has ushered in a new era of research and precision medicine, offering targeted modifications in genetic sequences. However, the power of CRISPR comes with a complex challenge– edits often yield heterogeneous outcomes. In this session, Travis Hardcastle, Product Manager at Synthego, and Brittany Enzmann, Product Manager at Mission Bio, delve into the intricacies of CRISPR editing and dissect the heterogeneity of editing outcomes and their implications. They explore the cutting edge in cell engineering, including automated gene editing on Synthego’s Eclipse platform to generate reproducible results and multi-guide RNA approaches for high efficiency knockouts and Mission Bio introduces a transformative single-cell assay for measuring CRISPR outcomes to dissect zygosity, co-occurrence, and off-target edits. #Crispr #genomeediting #baseediting #singlecell #singlecellanalysis #NGS #multiomics #Singlecellmultiomics #Missionbio #Synthego

Impressive work to engineer a chimeric Cas nuclease which could expand the reach of gene editing to a wider window of potential therapeutic targets (less restricted in terms of PAM sequence) #crispr #geneediting