Centre for Molecular Biosciences & Genomics’ Post

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Multi-omics in Biomedical Research Multi-omics is enhancing biomedical research by integrating data from various omics disciplines including: genomics, transcriptomics, proteomics, metagenomics and metabolomics to provide a comprehensive understanding of disease aetiology and pathogenesis. This approach enables researchers to discover biomarkers for early diagnosis of both infectious and non-communicable diseases. Additionally, multi-omics approaches may enable scientists to identify potential targets for the development of drugs. With the rising incidence of antimicrobial resistance, this can be instrumental in the development of novel antibiotics. Finally, by combining multi-omics data with advanced computational tools like AI and machine learning, we can create predictive models for personalized medicine, offering more precise treatment options tailored to individual patients’ molecular profiles. Image source: BioRender #MultiOmics #Genomics #Transcriptomics #Proteomics #Metabolomics #Metagenomics #PrecisionMedicine #DrugDevelopment #BiomedicalResearch #AI #ML

The Role of Genomics in Preserving Endangered Species Genomics is transforming how we approach the preservation of endangered species, offering powerful tools to safeguard biodiversity. By studying the genomes of endangered animals, we gain crucial knowledge into their genetic diversity, health, and how they adapt. This information is crucial to developing targeted conservation strategies. For instance, genomics allows us to identify populations with low genetic diversity, which is vital for preventing inbreeding and ensuring long-term survival. It also helps us understand the genetic traits that enable species to thrive in specific environments, guiding breeding programs and reintroduction efforts. Moreover, genomics plays a crucial role in combating illegal wildlife trade by tracing the origins of captured animals. This helps protect vulnerable populations from exploitation. In the fight against diseases that threaten endangered species, genomics reveals genetic factors associated with disease resistance, enabling us to breed stronger, more resilient populations. By utilizing the power of genomics, we can create more effective conservation strategies, ensuring that endangered species not only survive but flourish in the wild. It’s an exciting time for conservation, where science meets wildlife management, and together, we can make a lasting impact. At CMB Genomics, we are dedicated to using genomic technology to advance research in the conservation of endangered species. We invite conservationists, researchers, and funding organizations to collaborate with us as we explore innovative strategies to protect our planet's vulnerable wildlife. Contact us at CMB Genomics to learn more about our initiatives and discuss potential partnerships for impactful conservation efforts. #CMBGenomics#Genomics #Conservation #EndangeredSpecies #Biodiversity #WildlifePreservation #Sustainability

Application of Genomics in Infertility Research Around 17.5% of the adult population, roughly 1 in 6 worldwide experience infertility, according to WHO reports. Genomics is becoming essential in understanding the underlying causes of this challenge. Research indicates that genetic factors contribute to about 15-25% of infertility cases, influencing conditions like diminished ovarian reserve and sperm production issues. One important area of research is discovering specific genetic mutations that interfere with fertility. These studies' findings not only add to our understanding of reproductive issues, but also help clinicians make treatment decisions. Furthermore, advances in genetic testing are paving the way for personalized care in reproductive treatment. Healthcare providers can personalize interventions to each patient's individual needs, increasing their chances of successful conception. As we investigate the complex relationship between genetics and fertility, ongoing research provides hope for couples looking to start families. Could genomics hold the answer to addressing unexplained infertility? At CMB Genomics, we are particularly interested in using genomic technology to help advance research in this crucial sector. We invite healthcare providers, researchers, and funding agencies to collaborate with us as we investigate ways to improve our understanding of infertility. Contact us at CMB Genomics to learn more about our focus and how we can collaborate for impactful research. #Infertility #Genomics #PersonalizedMedicine #FertilityResearch #WHO #GeneticTesting #ReproductiveHealth #IVF #FamilyPlanning

Genomics in Neglected Tropical Diseases Research Genomics plays a pivotal role in advancing research on neglected tropical diseases (NTDs), offering insights into disease vectors, drug resistance, and host-parasite interactions. By profiling disease vectors, genomics helps track the evolution of resistance to control measures, enabling the development of more effective interventions. Additionally, it aids in understanding host-parasite interactions at the molecular level, revealing potential drug targets for more targeted therapies. The identification of genetic markers linked to drug resistance is also critical for monitoring treatment efficacy and developing new therapies. At CMB Genomics, we are dedicated to NTD research. One of our recent projects investigated the prevalence of female genital schistosomiasis among women of reproductive age in Kilifi using PCR, revealing a high prevalence rate of 36.0%. Our work underscores the importance of genomics in addressing NTDs and highlights our commitment to innovative solutions for improving global health outcomes. #NTDs #Genomics #Molecularbiology #AMR #Drugdiscovery #Schistosomiasis #FGS

Meet the Team: Zakayo Maingi Zakayo Maingi is a distinguished postdoctoral researcher at CMB Genomics with a strong focus on mycobacterial genomics and antimicrobial resistance. He currently serves as a lecturer in the Department of Medical Laboratory Sciences at Meru University of Science and Technology, where he teaches microbiology and molecular biology courses. His dedication to both research and education has positioned him as a key figure in the field of infectious diseases, particularly in tuberculosis and nontuberculous mycobacteria (NTM). He has been awarded two research grants from Meru University, which supported his study on the molecular characterization of NTM among symptomatic TB-negative patients in Kenya. This work was critical in understanding the genetic mechanisms and epidemiology of NTM infections, which are increasingly recognized as important public health issues. His research is supported by his robust academic background, having earned a Ph.D. in Tropical and Infectious Diseases through a competitive scholarship at the University of Nairobi, and a strong foundation in Medical Laboratory Sciences. Dr. Zakayo has demonstrated a high level of expertise through multiple first-author publications in leading scientific journals, highlighting his extensive experience in microbiological techniques and genomic research. His commitment to advancing his skills and knowledge is evident from his participation in several prestigious training programs, including the H3Africa BioNet and the Genomics and Bioinformatics course by Wellcome Connecting Science, held at Stellenbosch University in South Africa. These opportunities have further refined his skills in genomics and bioinformatics, enhancing his research capabilities. In addition to his academic and research roles, Dr. Zakayo is actively involved in collaborative efforts globally. He is a key collaborator in the NTM-Africa consortium project, which is currently being established to address the challenges posed by nontuberculous mycobacteria across the African continent. His proactive engagement with potential collaborators worldwide reflects his commitment to fostering international research partnerships. Moreover, Dr. Zakayo is passionate about mentoring students and upcoming scientists. His role as an educator allows him to share his expertise and inspire the next generation of healthcare professionals, emphasizing the importance of rigorous scientific inquiry and collaboration. His dedication to mentorship and education is driven by a desire to build a strong, future-ready scientific community that can tackle emerging global health challenges Marianne Wanjiru Mureithi Frank G. Onyambu Wallace Bulimo Meru University of Science and Technology (MUST) #InfectiousDiseases #TropicalMedicine #Molecularbiology #Genomics