Cerba Research’s Post

Spinal muscular atrophy (SMA) is a rare, genetic neuromuscular disease caused by a lack of survival motor neuron (SMN) protein, which is essential for muscle development. When SMN levels are low, motor neurons in the spinal cord are lost, leading to muscle weakness and wasting. SMA treatment aims to preserve motor neurons to slow disease progression. We are exploring the potential of our SMA therapy through robust research efforts. Learn more about our latest data: https://ow.ly/8Rth50TgyBx #News | #SpinalMuscularAtrophy | #SMA | #RareDisease

INNOVATIONS ADVANCED BY M&A: Pompe disease, a rare genetic disease that causes progressive muscle deterioration, was first identified in 1932 by Dutch neurologist Dr. Johannes Pompe but it wasn’t until 2006 that the first treatment for Pompe was brought to market. Read our latest blog to learn how M&A helped make this long-anticipated breakthrough possible: https://lnkd.in/g4b4Fyag

Abnormal phase transitions have been implicated in the occurrence and the progression of neurodegenerative diseases. If you are interested in analyzing the role of liquid-liquid phase separation in neurotoxic signaling, apply for the project offered by the Tatzelt lab at IMPRS-LM International Max Planck Research School for Living Matter. #PhDposition #neurodegenerativediseases #PhDprogram

🧠 Did you know that the sensitization of the trigeminocervical nucleus (TCN) is one of the contributing factors to the development of headaches? ⬆️ TCN is modulated by higher centers in the brain. ⬇️ There's a descending inhibitory system that should control that. But genetically, some people might have some impairment of that inhibitory system, so the TCN becomes abnormally sensitized and triggers headache. We also know that the TCN is influenced by the musculoskeletal system, cervical musculoskeletal system, and also by the trigeminal system. So we have all these different competing parts trying to alter sensitivity of the TCN. ✅ Start your 7-day free trial at Trust Me-Ed and watch the lecture 'Headache: Assessment and Treatment' by Dr. Toby Hall! You can watch the full lecture here 👇 🔗 https://lnkd.in/e9VPSvBJ

May is Huntington's Disease Awareness Month. #HuntingtonsDisease (HD) is a rare genetic disorder that causes gradual and progressive neuronal degeneration which leads to motor and cognitive impairment. At Curia, we take pride in our collaborations to enable the development of HD research tools and reagents which may lead to future treatments. Our contributions include providing essential HTT proteins, DNA MMR enzymes, and novel small molecules that are helping to advance HD research. >>> Discover the HTT proteins we produce: https://ow.ly/FBBk50RYr8W >>> To learn how Curia can advance your HD program, speak with our experts: https://ow.ly/o4OG50RUn2E #DrugDiscovery #HDAwarenessMonth #smallmolecules #CDMO

Dr. Allison Ashley-Koch from Duke University discussed her latest research in the genetics of Chiari malformation at our recent annual conference. ▪ About 12% of CMI patients have evidence of connective tissue disorders (CTD). ▪ Multiple genes contribute to CMI, many of which are involved in bone and connective tissue growth. ▪ Different genes are associated with CTD+ or CTD- forms of CMI. ▪ Different genes are involved with pediatric onset cases compared to adult cases. Watch the full presentation on our YouTube channel: https://lnkd.in/e_uvyc8b #ChiariResearch #GeneticsAndChiari #ChiariMalformationAwareness #ASAP2024

August is Spinal Muscular Atrophy (SMA) Awareness Month! 🧠 Did you know? SMA is a genetic disorder that affects the motor neurons, leading to muscle weakness and atrophy. It's one of the leading genetic causes of infant mortality, but early diagnosis and treatment can make a significant difference. 🔬 Our ongoing clinical trials are focused on advancing treatments and improving outcomes for those affected by SMA. Your support helps drive vital research and offers hope to families. Learn more about our SMA clinical trials and how you can get involved: https://ow.ly/AMBc50SXTim #SMAAwareness #SpinalMuscularAtrophy #Research #ClinicalTrials #HopeForSMA #UCSD #UCSDACTRI #UCSanDiegoHealth

Muscular Dystrophy Happens When Multiple Genetic Diseases Combine, It Causes Weakness In The Body And Severe Muscle Loss. There Are Lots Of Therapies Are Available For Muscle Dystrophy But There Are No Any Definite Treatment Which Is Well- Proven To Cure This Disease Permanently. That Is Why Its Very Difficult To Recognize The Symptoms Of This Condition To Better Management. https://lnkd.in/grksZnwk #muscular dystrophy

Unlocking New Pathways: Rev-erb Alpha’s Role in Neuroprotection and Anti-Inflammation Pharmacological activation of rev ERB alpha-a pathway that controls circadian rhythms counteracts neuroinflammation. Genetic deletion of revERB causes brain inflammation and exacerbates inflammatory reactions to LPS. https://lnkd.in/eHv7fi73

Welcome to join my Webinar on 8th February on "Mitochondrial Insights".🤓