Cerevance’s Post

📃Scientific paper: Thyroid hormone action during GABAergic neuron maturation: The quest for mechanisms Abstract: International audience; Thyroid hormone (TH) signaling plays a major role in mammalian brain development. Data obtained in the past years in animal models have pinpointed GABAergic neurons as a major target of TH signaling during development, which opens up new perspectives to further investigate the mechanisms by which TH affects brain development. The aim of the present review is to gather the available information about the involvement of TH in the maturation of GABAergic neurons. After giving an overview of the kinds of neurological disorders that may arise from disruption of TH signaling during brain development in humans, we will take a historical perspective to show how rodent models of hypothyroidism have gradually pointed to GABAergic neurons as a main target of TH signaling during brain development. The third part of this review underscores the challenges that are encountered when conducting gene expression studies to investigate the molecular mechanisms that are at play downstream of TH receptors during brain development. Unravelling the mechanisms of action of TH in the developing brain should help make progress in the prevention and treatment of several neurological disorders, including autism and epilepsy. Discover the rest of the scientific article on es/iode ➡️https://etcse.fr/w3cT

📃Scientific paper: Thyroid hormone action during GABAergic neuron maturation: The quest for mechanisms Abstract: International audience; Thyroid hormone (TH) signaling plays a major role in mammalian brain development. Data obtained in the past years in animal models have pinpointed GABAergic neurons as a major target of TH signaling during development, which opens up new perspectives to further investigate the mechanisms by which TH affects brain development. The aim of the present review is to gather the available information about the involvement of TH in the maturation of GABAergic neurons. After giving an overview of the kinds of neurological disorders that may arise from disruption of TH signaling during brain development in humans, we will take a historical perspective to show how rodent models of hypothyroidism have gradually pointed to GABAergic neurons as a main target of TH signaling during brain development. The third part of this review underscores the challenges that are encountered when conducting gene expression studies to investigate the molecular mechanisms that are at play downstream of TH receptors during brain development. Unravelling the mechanisms of action of TH in the developing brain should help make progress in the prevention and treatment of several neurological disorders, including autism and epilepsy. Continued on ES/IODE ➡️ https://etcse.fr/w3cT ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you.

📃Scientific paper: Thyroid hormone action during GABAergic neuron maturation: The quest for mechanisms Abstract: International audience; Thyroid hormone (TH) signaling plays a major role in mammalian brain development. Data obtained in the past years in animal models have pinpointed GABAergic neurons as a major target of TH signaling during development, which opens up new perspectives to further investigate the mechanisms by which TH affects brain development. The aim of the present review is to gather the available information about the involvement of TH in the maturation of GABAergic neurons. After giving an overview of the kinds of neurological disorders that may arise from disruption of TH signaling during brain development in humans, we will take a historical perspective to show how rodent models of hypothyroidism have gradually pointed to GABAergic neurons as a main target of TH signaling during brain development. The third part of this review underscores the challenges that are encountered when conducting gene expression studies to investigate the molecular mechanisms that are at play downstream of TH receptors during brain development. Unravelling the mechanisms of action of TH in the developing brain should help make progress in the prevention and treatment of several neurological disorders, including autism and epilepsy. Continued on ES/IODE ➡️ https://etcse.fr/w3cT ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you.

📃Scientific paper: Thyroid hormone action during GABAergic neuron maturation: The quest for mechanisms Abstract: International audience; Thyroid hormone (TH) signaling plays a major role in mammalian brain development. Data obtained in the past years in animal models have pinpointed GABAergic neurons as a major target of TH signaling during development, which opens up new perspectives to further investigate the mechanisms by which TH affects brain development. The aim of the present review is to gather the available information about the involvement of TH in the maturation of GABAergic neurons. After giving an overview of the kinds of neurological disorders that may arise from disruption of TH signaling during brain development in humans, we will take a historical perspective to show how rodent models of hypothyroidism have gradually pointed to GABAergic neurons as a main target of TH signaling during brain development. The third part of this review underscores the challenges that are encountered when conducting gene expression studies to investigate the molecular mechanisms that are at play downstream of TH receptors during brain development. Unravelling the mechanisms of action of TH in the developing brain should help make progress in the prevention and treatment of several neurological disorders, including autism and epilepsy. Discover the rest of the scientific article on es/iode ➡️https://etcse.fr/w3cT

Identification of senescent, TREM2-expressing microglia in aging and Alzheimer's disease model mouse brain 🧬 The research focuses on the TREM2 gene, identified as an Alzheimer’s Disease risk factor, revealing two distinct types of microglia: senescent microglia and TREM2-dependent disease-associated microglia (DAM). 🐁 Utilizing high-throughput mass cytometry in the 5×FAD mouse model, the study uncovered a unique senescent microglial signature linked to cognitive decline across various models including aging, amyloidosis, and tauopathy. 🚫 In TREM2-null mice, fewer senescent microglia were observed, highlighting TREM2's complex role in microglial states. 💊 Treatment with the senolytic BCL2 family inhibitor ABT-737 reduced senescent microglia and improved cognitive functions without affecting DAM populations, suggesting potential therapeutic avenues. 🧠 The findings emphasize the dual and opposing effects of TREM2 in microglial behavior, underscoring the necessity for nuanced approaches in targeting TREM2 for Alzheimer’s therapy. From Nature: https://lnkd.in/gwhayend #AlzheimersResearch #Neuroscience #Microglia #TREM2 #BrainHealth #DementiaCare #ScientificDiscovery #Biotechnology #AgingResearch #CognitiveDecline

Using human cells and postmortem brain samples, Tracy Young-Pearse's lab at Brigham and Women's Hospital and Harvard Medical School studied how CRISPR deletion of the SORL1 gene affects different human brain cells, contributing to #AlzheimersDisease. https://lnkd.in/damshQtz “This is getting at a precision neurology approach, with which we can better predict which patients may be responsive to Alzheimer’s treatment strategies that attack specific genes or target the problems they cause.” - https://lnkd.in/dhdnhCdY 🗞 Cell Press's #CellReports ✍ also include Hyo Lee, Aimee Aylward, Richard Pearse, Alex Lish, Yi-Chen Hsieh, Zachary Augur, Courtney Benoit, Vicky Chou, Allison Knupp, Cheryl Pan, Srilakshmi Goberdhan, Duc Duong, Nicholas Seyfried, David A. Bennett, Mariko Taga, Kevin Huynh, Matthias Arnold, Peter Meikle, Philip De Jager, Vilas Menon, and Jessica Young 🏫 Collaborating institutions include the University of Washington, Emory University School of Medicine, Rush University Medical Center, Columbia University Irving Medical Center, Baker Heart and Diabetes Institute, La Trobe University, Helmholtz Munich, and Duke University #neurology #neuroscience #brainresearch #alzheimers #neurodegenerativedisease #CRISPR #invitro #iPSCs #humanrelevantresearch #nonanimalmethods #precisionmedicine

Microglia, the sentinel cells of the central nervous system, play a crucial role in maintaining brain health and responding to diverse neuronal injury or disease. Recent research has highlighted the importance of microglia in various neurological disorders, including rare genetic brain disorders. These rare genetic brain disorders, such as Rett syndrome (mutant MECP2) and Nasu-Hakola disease (Mutant TREM2), are associated with microglial dysfunction. TREM2 gene mutations, which are primarily expressed in microglia, are responsible for Nasu-Hakola disease, leading to neuroinflammation, synaptic dysfunction, and neurodegeneration. However, due to lack of earlier human relevant microglia cell type, it was difficult to study such rare brain genetic disorders and recent advancements in the field, we can now functionally differentiate microglia from human iPSC cells and model these rare genetic disorders through gene editing technology. These breakthroughs offer valuable opportunities to unravel the complex interplay between genetics, microglial function, and brain health. Understanding the roles of microglia in rare genetic brain disorders is crucial for developing effective treatments and drug screening for those affected. #Microglia #BrainHealth #NeurologicalDisorders #Research #GeneEditing #RareBrainGeneticDisease #Neuroinflammation #Rettsyndrome #NasuHakoladisease Further Readings: https://lnkd.in/gwh3dxub

Researchers have mapped gene switches in different brain cell types by analysing over a million human brain cells. This study, part of the BRAIN Initiative, highlighted the relationship between certain cell types and neuropsychiatric disorders. They further used AI to forecast the effects of specific high-risk gene variants. 13 October 2023, Science. DOI: 10.1126/science.adf7044 https://bit.ly/3FrMbo0

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are part of a disease spectrum linked to genetic mutations in various genes, particularly those associated with the endolysosomal system. Recent research suggests that disrupting the endolysosomal system, rather than just autophagy, could be a crucial driver of the disease. This review explores the connections between ALS/FTD and the endolysosomal system, including the involvement of disease-associated genes and potential effects on the brain beyond autophagy disruption. https://lnkd.in/et-BwdJi #genetics #genomics #precisionmedicine #genomicmedicine #als #ftd #brain #neurology #neurodegeneration #neuroscience #lysosome #raredisease #pathogenesis #autophagy #omics #therapeutics #biomarkers #biotechnology #innovation #research #science #sciencecommunication

I'm thrilled to announce our recent publication in Frontiers in Aging Neuroscience titled "A Systematic Review on Alzheimer’s Disease Development in In Vitro Models: Exploring Different Inducing Agents." This extensive review thoroughly investigates the range of inducing agents utilized in in vitro models to explore Alzheimer's disease, offering valuable insights into the multiple mechanisms of neurodegeneration. This publication marks a significant stride towards better comprehension of Alzheimer's pathology and the exploration of potential therapeutic avenues. Read the full article here: https://lnkd.in/eBVQit_a