Charles River Laboratories’ Post

The manifestation of an immune response can result in #ocular inflammation impacting study duration, power, and the ability to meet objectives. Using immunosuppression can help mitigate inflammatory impact but may not completely quench the response. In this presentation, we explore the ethical and scientific considerations for using immunosuppression in non-clinical ocular studies and the benefits, concerns, and strategies for its use. https://okt.to/F9dkHy

The manifestation of an immune response can result in #ocular inflammation impacting study duration, power, and the ability to meet objectives. Using immunosuppression can help mitigate inflammatory impact but may not completely quench the response. In this presentation, we explore the ethical and scientific considerations for using immunosuppression in non-clinical ocular studies and the benefits, concerns, and strategies for its use. https://okt.to/RSk7fF

The manifestation of an immune response can result in #ocular inflammation impacting study duration, power, and the ability to meet objectives. Using immunosuppression can help mitigate inflammatory impact but may not completely quench the response. In this presentation, we explore the ethical and scientific considerations for using immunosuppression in non-clinical ocular studies and the benefits, concerns, and strategies for its use. https://okt.to/YZAgO1

Explore Parkinson's disease pathogenesis in a new scientific journal article co-authored by Suruchi Bakshi , Certara's Principal Quantitative Systems Pharmacologist, alongside Govind Menon and J. Krishnan from Imperial College London.   Titled "The Interaction of Core Modules as a Basis for Elucidating Network Behavior Determining Parkinson's Disease Pathogenesis," this perspective paper introduces an approach based in dynamical systems theory to understanding the disease's intricate mechanisms.   Discover how the team combined key subnetwork interactions, focusing on alpha-synuclein's role in reactive oxygen species and proteasomal feedback pathways, to uncover emergent behaviors, potential treatment avenues, and broader implications for patient care and modeling strategies.   Read the full analysis and gain insights into systems medicine treatment options: https://ow.ly/Qj0w50QIK1G   #ParkinsonsResearch #Pathogenesis #TreatmentStrategies #SystemsMedicine #QSP #QuantiativeSystemsPharmacology

Happy to share this leading edge article about Resmetirom for the treatment of MASH fibrosis. https://lnkd.in/dK5_2JBm. A perspective on biological insight and clinical implications.

Proud to share my new publication 'Activation of AMPK/mTOR-Driven Autophagy and Suppression of the HMGB1/TLR4 Pathway with Pentoxifylline Attenuates Doxorubicin-Induced Hepatic Injury in Rats'. Explored protective mechanisms against drug-induced liver damage. #ResearchPublication #PharmacologyResearch"

In a new article in The FASEB Journal, scientists investigated how regular moderate aerobic exercise (RMAE) helps improve ulcerative colitis and discovered that a substance called β-hydroxybutyrate (β-HB), plays a crucial role in this process. The study also reveals a new understanding of how exercise-related substances like β-HB contribute to reducing inflammation in ulcerative colitis. Read more at: https://hubs.ly/Q02nLPqH0