Charles Sillett’s Post

I am delighted to share that our recent article"Immediate Destiny of Bifurcation Lesions Treated with Biomatrix Alpha Stents" has been published in Cardiovascular & Hematological Disorders-Drug Targets journal. Special thanks to my fellow authors who contributed to this work. Dr mahdi zahedi 🙏🏻 #Cardiology #Cardiovascular_disorders Bentham Science https://lnkd.in/dGdTQvdM

Congrats to our colleague Biswajoy Ghosh for another well written paper "Molecular histopathology of matrix proteins through autofluorescence super-resolution microscopy". This one shows how MUSICAL can be used for early detection of conditions like fibrosis using a method called MUSI-tAF. Read more about it in his blog post https://lnkd.in/ef_tyU9x

New Case Report! "All that Doesn’t Enhance Isn’t a Thrombus: Pitfalls Using Cardiac MRI TI 600 Sequence to Distinguish Between Cardiac Thrombus Versus Myxoma" by Drs. Aakash Rana, Srikanth Vallurupalli, Mark Mitchell, David Duncan & Jack Xu. A 51-year-old male with a complicated medical history presented with shortness of breath. Preoperative workup confirmed the presence of a large atrial mass. However, delayed gadolinium enhancement CMR with long inversion time (TI 600) showed lack of enhancement, which was suggestive of a thrombus. During cardiac magnetic resonance imaging, delayed gadolinium enhancement sequences with long inversion time are used to distinguish between an avascular thrombus versus a vascular tumor. See more at Methodist DeBakey Cardiovascular Journal https://lnkd.in/gwsE98Pe

#Review Electromagnetic Torso Scanning: A Review of Devices, Algorithms, and Systems by Sasan Ahdi Rezaeieh, Amin Darvazehban, Azin S. Janani and Amin M. Abbosh https://lnkd.in/eNcsDvFK MDPI The University of Queensland #torsoscanning #antennas #processingalgorithms #electromagneticimaging #openaccess #Abstract The past decade has witnessed a surge into research on disruptive technologies that either challenge or complement conventional thoracic diagnostic modalities. The non-ionizing, non-invasive, compact, and low power requirements of electromagnetic (EM) techniques make them among the top contenders with varieties of proposed scanning systems, which can be used to detect wide range of thoracic illnesses. Different configurations, antenna topologies and detection or imaging algorithms are utilized in these systems. Hence, to appreciate their progress and assess their potential, a critical review of EM thoracic scanning systems is presented. Considering the numerous thoracic diseases, such as fatty liver disease, lung cancer, respiratory and heart related complications, this paper will exclusively focus on torso scanning systems, tracing the early foundation of research that studied the possibility of using EM waves to detect thoracic diseases besides exploring recent progresses. The advantages and disadvantages of proposed systems and future possibilities are thoroughly discussed.

This is a great summary of the recently published EMERALD II study led by Bon-Kwon Koo at Seoul National University and supported by HeartFlow, Inc. This study evaluated the use of AI-enabled Quantitative Coronary Plaque and Hemodynamic Analysis measures computed by HeartFlow. This study once again demonstrates the value of combining anatomic, plaque and hemodynamic measures in identifying lesions causal of Acute Coronary Syndromes.

The intricate 3D structure of the biliary tree in a P7 (postnatal day 7) mouse liver is revealed with our NIH BRAIN Initiative-funded tissue clearing kits. At this critical developmental stage, the liver is undergoing significant growth. Understanding the development of the biliary system helps researchers gain insights into liver function, development, and the etiology of hepatic diseases. Sample prepared by Yessenia Gallegos, with imaging performed on the #ZEISS Lightsheet Z.1 by Eric Blaes. Learn more about our services and how you can perform 3D staining of your tissue of interest with our NIH BRAIN Initiative-funded tissue clearing kits. https://lnkd.in/gdagkqB The National Institutes of Health, #NIH, #BRAINInitiative, ZEISS Microscopy, #DevBio, #DevelopmentalBiology, #liverdisease

#UPCOMINGWEBINAR | Getting to the Heart of Cardiovascular Research Dr. Melanie White presents the various methods for assessing cardiac function in the context of pathology, spanning from in vitro to in vivo techniques + more! REGISTER HERE: 👉 https://lnkd.in/gSuJuD5Q 👈 #ADInstruments #MakingScienceEasier #CardiacResearch

Visualization of liver vasculature using Smooth Muscle Actin (SMA) in the whole mouse liver. Tissue clearing and staining for SMA enables the use of #lightsheet imaging to visualize the vascular networks in the liver. This approach provides robust insights into vascular networks, often implicated in liver diseases. Tissue clearing provides more comprehensive insights compared to traditional 2D slice immunohistochemistry (IHC) methods. Sample preparation was conducted by our undergraduate intern, Nathan Hyman, using the Translucence Universal Tissue Clearing Kit. This NIH-funded kit is suitable for clearing various tissue types, including mouse brain, lung, liver, spinal cord, and more. Imaging was performed on the ZEISS Lightsheet Z.1 by Eric Blaes. Learn more about our services and how our tissue clearing kits, funded by the NIH BRAIN Initiative and NIMH, can assist you in implementing tissue clearing in your lab. For more information, visit our website. https://lnkd.in/gDb4QA2r The National Institutes of Health, National Institute of Mental Health (NIMH), #NIH, ZEISS Microscopy, #ZEISS, #Lightsheet, #LSFM

This was the last #XLIF case of 2023. The patient is a 42 years old immunosuppressed tumor patient with a bacterial spondylodiscitis at L4-5 and a lytic spondylolisthesis at L5-S1.   The difficulty was the regional anatomy shown in the preoperative imaging.   Purple arrow shows the line of approach above the iliac crest. The left kidney (LK) is hanging deep in the pelvis and had to be mobilized to visualize the psoas muscle. A massive ascending lumbar vein (blue arrow) is crossing the L4-5 disc space posteriorly (emptying into the left common iliac vein) and has to be protected intraoperatively.   Even though these approach-related difficulties these patients profit largely from the single level fusion, a wide cage which is not subsiding into the weakened endplates and the possibility to remove as much infected disc material as possible. It was performed as #singlepositionlateral .   #XLIF #NuVasive #Globus    Alfredo Guiroy Ashish Patel Alex Thomas Brett Braley Christiano M Menezes Jake Timothy Samir Smajic

Cardiovascular research.......Langendorff isolated heart perfusion technique.... Great to be a part of this event hosted in line of cardiovascular system. Special Thanks to InsideScientific and ADInstruments for hosting this event. Got some meaningful information about Langendorff system... Workflow, heart parameters, robustness of techniques, exclusion criterias, and much more.