Charnwood Discovery’s Post

Occasionally you come across something really unique in the literature that causes a stir amongst organic chemists. Today it's the "Aminative Suzuki" reaction. https://lnkd.in/e_pWpYpy Liu et al. have developed a really unique approach for forming diaryl amines using traditional Suzuki chemistry rather than using the classical Buchwald approach. The team discovered that by including an amine source in a standard Suzuki reaction, in this case O-diphenylphosphinyl hydroxylamine (DPPH), that unsymmetrical diaryl amines were produced. The reaction is robust, has a wide functional group tolerance, and can be applied towards the synthesis of pharmaceutically relevant building blocks. Allylation and 4-component couplings were also demonstrated. One downside that is apparent from a PR&D/scaleup perspective is that the amine source, DPPH, is definitely a high energy compound so proceed with care if you are trying this exciting new reaction out for the first time. https://lnkd.in/ees7wpxN

#Flash #chromatography market size is projected to grow from USD 0.32 Billion in 2023 to USD 0.5 Billion by 2032, exhibiting a compound annual growth rate (CAGR) of 5.20% during the forecast period (2023 - 2032), says Market Research Future Get More Details at: https://lnkd.in/dPEUJfD6 Flash chromatography is a rapid and efficient purification technique widely used in organic chemistry. Employing a column filled with silica gel or other adsorbents, this method separates compounds based on their polarity and size. A liquid solvent, the mobile phase, is forced through the column, carrying the sample with it. The diverse interactions between the sample and the stationary phase result in differential migration rates, facilitating purification. Flash chromatography is prized for its speed, #versatility, and cost-effectiveness, making it indispensable for isolating target compounds from complex mixtures in drug discovery, #natural product synthesis, and various research applications. Some of the key players in the market are Biotage, Thermo Fisher Scientific, SHIMADZU CORPORATION, PerkinElmer, Inc., GE HealthCare, Agilent Technologies, Inc., INTERCHIM SA, Tosoh Corporation, Teledyne ISCO, Gilson., Waters Corporation, WR Grace and Company #OrganicChemistry #DrugDiscovery #PurificationTechnology #SilicaGel #ChemicalAnalysis #MarketResearchFuture #marketresearch #consultingservices #consultingfirms #consultingbusiness #mrfr

ARGEN is specifically tailored for the rapid characterization and assessment of the stability and viability of therapeutic #biopolymers such as #proteins, peptides, nucleic acids, polysaccharides, viral vectors, LNP-mRNA vaccines, and bioconjugates. It addresses the common issue of aggregation that occurs when biopolymers deviate from their native states under various stress conditions like thermal, chemical, or mechanical stress. Click here to download the eBook today to learn more about how ARGEN can expedite formulation development efforts and for case studies on thermal, chemical, and mechanical stability, interfacial behavior, and material interactions. #RNA #rnatherapeutics #biotech https://lnkd.in/gBsfvyUD

C-Glycosyl compounds (C-glycosides) are a class of saccharide derivatives with improved stability over their O-linked counterparts. This paper reports the synthesis of several trans-2-(C-glycosyl)acetates via a tandem Wittig–Michael reaction from pyranoses (cyclic hemiacetals) using continuous flow processing, which gave improvements compared to reactions conducted in round-bottom flasks. Products were isolated in yields of >60% from reactions of benzyl-protected xylopyranoses, glucopyranoses, and galactopyranoses at higher temperatures and pressures, which were superior to yields from batch procedures. Our Flow Chemistry platform can provide various reaction testing and production, which accelerate your R&D and production progress. #FlowChemistry #glycosides #ProcessChemistry #MichaelReaction #WittingReaction #FFS #FTE https://lnkd.in/gk7JdxBj

Happy to share our latest research published in the Journal of Organic Chemistry (JOC). Herein, we describe the [2+2] synthesis of a benzoyl based C2-O-sLeX-Thr-COOH building block devoid of any aglycone transfer or orthoester formed byproducts. Also reported is an efficient [2+1+1] synthesis of a peracetylated sLeX en route to a peracetylated C2-O-sLeX-Thr-COOH. Importantly, the current report details the role of a variety of hydroxy protecting groups, including acetyl, benzoyl, p-methoxy benzyl and naphthylmethyl that may be considered in designing a route to this complex glycan amino acid. The insights gained in formulating this design strategy can be broadly applied to the synthesis of a wide variety of biologically important oligosaccharides and O-glycan bearing glycopeptides. https://lnkd.in/edprDPia

Aggregation typically occurs when #biopolymers deviate from native states under thermal, chemical, or mechanical stress conditions. ARGEN was designed for the rapid characterization and assessment of the stability and viability of therapeutic biopolymers. These include #proteins, #peptides, nucleic acids, polysaccharides, viral vectors, LNP-mRNA vaccines, and bioconjugates. Download our eBook today to learn how to expedite your formulation development efforts with thermal, chemical, and mechanical stability, interfacial, and material interaction studies, all in one instrument. #DNA #RNA #biotech https://lnkd.in/gBsfvyUD

Need to rapidly synthesise peptides at scale? The Peptide-Scaleup utilises Vapourtec’s patented variable bed flow reactor (VBFR) which ensures fast cycle times even at the largest scale. Manuel Nuño, PhD explained: “This Peptide-Scaleup system is designed for peptide chemists looking for a more productive and time-efficient synthesis, especially in comparison with traditional batch techniques" Benefits include: ✅ Typically a 30-mer peptide can be synthesised at 4 mmol scale in just 16 hours ✅ Highest quality crude peptides at large scale, minimises demands on purification ✅ Minimises solvent and reagent usage compared with competing products ✅ Continuous in-line analytics, including resin solvation data and UV absorption data Purpose-built for chemists requiring speed and results, the Peptide-Scaleup is ideal for fluorenyl methoxycarbonyl protecting group (Fmoc) SPPS with DIC and oxyma activation. Interested to find out more? Click here 👉https://bit.ly/3RAmpnz #FlowChemistry #PeptideScaleUp #PeptideChemists #Chemistry

With the advantage of organocatalysis, a new approach has grown itself. Chiral organocatalysts traditionally operate through simplified enzyme-mimetic mechanisms, involving mild reaction conditions and an improved capability for the chemical inertness of the polymer matrix. Chirality plays an important role in chemistry. Due to stereospecific interactions of enantiomeric compounds with enzymes and receptors in biological systems, the physicochemical and biological properties can differ greatly. So it reveals a great application in the drug industry. In fact, the chiral drug industry constitutes approximately one-third of all drug sales worldwide. Enantiopure chiral compounds are also gaining applications in agrochemicals such as herbicides, insecticides, and fungicides. Asymmetric organocatalysis has the advantages of simple operation, mild reaction conditions, high yield, and high selectivity. But still, there were some limitations in the organic small molecule catalyst, such as a large amount of small molecule catalyst, difficulty in the product purification, and poor recycling performance, which will make it a non-greener catalyst and also limit its application in industrial production.

In recent work, Li Li et al. successfully developed Vinyltriphenylbismuthonium Tetrafluoroborate (“Vinyl-Bis”) for the direct α-vinylation of basic enolates (https://lnkd.in/gxtARBgs). These Vinyl-Bis reagent is ideal for researchers and chemists, it enables direct α-vinylation of carbonyl compounds, providing a simple, effective solution for complex molecular synthesis. Key Benefits: • Direct α-vinylation in a single step – simplifies your synthesis; • Stable and easy to handle – perfect for scaling up reactions; • Wide applicability – works with a variety of enolate precursors, including ketones and esters. Whether you’re focused on optimizing synthetic efficiency or exploring new reactions, Vinyl-Bis offers a practical, reliable pathway for your research. This reagent is available in our stock! 🛒 https://lnkd.in/gHf7cBPb 💡 Enamine offers a broad range of reagents and product subsets for organic synthesis that facilitate a wide variety of transformations. Explore all of them here https://lnkd.in/gFMXnPKj