Charnwood Discovery’s Post

There has been not 1, not 2, but 3(!!!) recent papers covering the impact and implementation of photochemical synthesis to drug discovery, which I’d like to take the time to highlight. Firstly, this perspective in OPRD takes an industry-wide view on adoption, looking at a range of different photochemical reactions employed at different stages of drug discovery. Whilst it’s not surprising to see more use in early discovery chemistry compared to development and manufacturing, there is increased interest in larger scale reactions, particularly those enabled by continuous flow chemistry. https://lnkd.in/dURFVpvP This second paper has a much more narrow focus and looks at the implementation of photoredox cross coupling reactions at AbbVie’s Discovery Chemistry function. It’s a great insight in how reducing barriers to adoption can promote the use of enabling technologies. In particular, the use of ChemBeads for dosing catalyst seems like it has great potential to reduce chemists’ inertia to new techniques. https://lnkd.in/dF_vYfJQ Finally, this perspective in J Med Chem does a great job of not only rounding up some of the state of the art in this area, but also highlighting the reasons why photo-chemical reactions can be so impactful in drug discovery. The ability to construct sp3-sp3 C-C bonds with intuitive synthetic logic should help facilitate the delivery of lead compounds with more desirable physicochemical properties. https://lnkd.in/dr-fj3WS Organic chemists are often accused of being somewhat cautious about the uptake of new techniques - hence the main tools of our trade, round bottom and Erlenmeyer flasks, haven’t changed much in around 200 years! Nonetheless, the enthusiastic uptake of techniques such as microwave reactors and automated purification shows that we are open to advances which show a clear benefit – it genuinely feels like certain aspects of photochem are on the cusp of making that transition from cool new technique to everyday part of our toolbox. #chemistry #drugdiscovery

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Worth a stop and chat on how Synple can make your research program efficient!

𝗕𝗼𝘀𝘁𝗼𝗻, Mark your calendars for the Medicinal Chemistry Strategy Meeting 2024 USA on November 13th. Discover the latest breakthroughs, network with industry experts, and gain insights to accelerate your drug discovery pipeline. https://lnkd.in/gMCu_mmq #ProventaBoston #MedicinalChemistry #DrugDiscovery #LifeSciences #StrategyMeeting

🎁 Lets talk chemical development, one of CatSci Ltd’s core offerings and a large part of any small molecule drug development. Click on the video below to check out Day 9, 10 and 11“Did You Know?”, or read below if you missed one! Remember to check back in Tuesday for "Did You Know" Day 12-14! 🌟 Interested in learning more? Feel free to connect with me, send me a message with any questions or send me an email at Autumn.Collins@CatSci.com! In case you missed a fact: Day 9- Robert Crook (he, him), Director of Chemical Sciences, has worked in the field of Chemical Sciences since 1993! -> Rob has 30 years of experience in Chemical Sciences! He contributed to Pfizer's Chemical Research and Development, led diverse technology areas, scaled continuous processing, and led Sandwich Chemical Development group (2011-2021), driving the approval of vital medicines. It is no wonder that his expertise and oversight results in such successful projects. Day 10- Selecting the right route for your asset can save you time and money. ->Accelerating assets to clinic is just one of the services we excel at. Between our great scientists, computer aided synthesis design and risk assessment tools we can create a route that fits your needs. Getting it right the first time and keeping you on track with your deadlines.   Day 11- We have in-house route assessment tools to help select the best route! ->These tools include our Route Costing Tool and our Measuring Chances of Technical Success (COTS) tool. Our costing tool helps choose the most cost-effective route for your synthesis. Our COTS tool considers literature and scientific expert opinions to determine the route with the greatest chance of technical success. #didyouknowseries #catsci #remotework #analyticalscience #businessdevelopment #ExcellenceInMedicinesDevelopment #ProudToBeChemistry #Chemistry #DrugDevelopment #APIManufacturing #CRO #smallmolecules #oligonucleotides #routescouting #routedevelopment

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Don't miss our workshop "𝐊𝐢𝐧𝐞𝐭𝐢𝐜 𝐒𝐞𝐥𝐞𝐜𝐭𝐢𝐯𝐢𝐭𝐲: 𝐚 𝐌𝐢𝐬𝐬𝐞𝐝 𝐎𝐩𝐩𝐨𝐫𝐭𝐮𝐧𝐢𝐭𝐲 𝐢𝐧 𝐃𝐫𝐮𝐠 𝐃𝐞𝐬𝐢𝐠𝐧?" at the #ACS National Medicinal Chemistry Symposium. 📅 Date: June 26, 2024, at 12:15 PM. 📍 Location: Session 6 - A Medicinal Chemist’s Toolbox Why you can’t miss our workshop: ✅ Learn how drug safety hinges not only on affinity but also on drug kinetic profiles. ✅ Discover how to maximize therapeutic windows by modifying on- and off-target kinetics earlier, building greater safety margins, and reducing adverse events using KINETICfinder®. ✅ Find out how to simplify and enhance covalent drug design using COVALfinder®. Don’t miss this opportunity to gain valuable insights and enhance your medicinal chemistry toolkit!