Chinese Peptide Company’s Post

Granisetron primarily functions as a serotonin 5-HT3 receptor antagonist, exerting its antiemetic effects by blocking the action of serotonin at these receptors. By antagonizing the 5-HT3 receptors, granisetron inhibits serotonin-mediated signaling that contributes to nausea and vomiting. Unlike some other antiemetic drugs, granisetron does not directly affect dopamine receptors (as seen with dopamine receptor antagonists like metoclopramide) or muscarinic receptors (as seen with anticholinergic drugs like scopolamine). Its specificity for serotonin receptors makes it a valuable option for managing chemotherapy- and radiotherapy-induced nausea and vomiting. SPD Chemicals offers below Granisetron intermediate, If you're interested in obtaining further details or making inquiries about the product, you can reach us on sujana@spdchemicals.com. Feel free to contact for more information regarding the purity, pricing, availability, and any other details you may require about the Granisetron intermediate we offer. #intermediate #api #CRO #CRAMS #chemicalindustry #chemical #SPDChemicals

Alkylating agent is the oldest & most useful of antineoplastic drugs which directly act on cells. In the middle of the 1940s, it was effectively used as an anticancer agent which was confirmed by clinical trials. Mode Of Action- Alkalyting Agent > produces carbonium ion > Transfer alkyl groups to cellular macromolecules by forming covalent bonds > abnormal base pairing > Inhibition of DNA synthesis. Classification - 1. Nitrogen Mustards. - Machlorethamine - Cyclophosphamide - Ifosfamide - Chlorambucil - Melphalan 2. Ethylenimine - Thio-TEPA 3. Alkyl sulfonate - Busulfan 4. Nitrosoureas - Carmustine - Lomustine 5. Triazine - Dacarbazine - Temozolomide 6. Platinum based - Cisplatin - Carboplatin - Oxaliplatin Nazmul Islam Mim pharmacist.

HYDROXY METHYL GLUTARYL CO ENZYME A REDUCTASE INHIBITORS (STATINS) :: Recent advances in the management of hypercholesterolemia are primarily due to the development of 3-hydroxy 3- methylglutaryl co -enzyme A (HMG Co A) reductase inhibitors or statins These drugs are competitive inhibitor of the enzyme HMG Co A that catalyses the early rate limiting step in cholesterol https://lnkd.in/dBH5Ysc4

PHARMACOKINETICS :: Salicylates are absorbed from the stomach and small intestine Sodium salicylate is absorbed more quickly than aspirin Upon local application methylsalicylate is absorbed from the intact skin After absorption 50 to 80 % of salicylate binds to plasma proteins it can displace other drugs eg. coumarin derivatives from the binding sites leading to severe bleeding an example of drug interaction https://lnkd.in/diYHSfkk

DSPE-PEG-PBP,DSPE is a phospholipid commonly used in the formulation of lipid-based drug delivery systems,providing stability and structure to the nanoparticles.PEGylation involves attaching PEG chains to the molecule,offering improved stability, circulation time, and reduced immunogenicity.The peptide sequence PBP(CDAEWVDVS) is attached to the PEG chain.  #DSPE #PEG #PBP #CDAEWVDVS #polyethylene #glycol #peptide https://lnkd.in/gVSE5myq

Sharing an optimized HPLC method using NanoPak-C All-Carbon reverse phase media to separate and purify semaglutide and liraglutide, important peptide drugs for treating type 2 diabetes and promoting weight loss. The method considers various factors including pH, mobile phase composition, flow rate, and temperature, and offers pH stability and unique selectivity for sustainable separation of peptides.

Buy high-quality Nitroso Stable Isotope Labeled Products from Simson Pharma. Take advantage of our competitive pricing and excellent customer service. 🔗https://lnkd.in/dPSf2HXz #NitrosostableIsotopeLabelledProducts #ImpurityStandards #IsotopeLabelledCompounds #Metabolites #Workingstandards #Simsonpharma #DeuteratedCompounds #DeuteratedCompoundsSuppliers #StableIsotopeLabelledProducts #SimsonPharma #CRO #ClinicalResearchOrganization #BioAnalyticals #BioEquivalence #ClinicalStudies #MethodDevelopment #Impurities

C-peptide CAS:59112-80-0 Custom Peptide Synthesis Name: C-peptide CAS No.: 59112-80-0 Purity: >95% Source: synthetic Apperance: white powder Note: For research use only #peptide #Cpeptide #custompeptide #peptidesynthesis

We have published a application note that briefly describes an optimized method for HPLC separation of Semaglutide and Liraglutide using NanoPak-C All-Carbon reverse phase media under acidic and alkaline conditions. These drugs (also known as glucagon-like peptide-1 (GLP-1) analogs) are used to treat type 2 diabetes and promote weight loss by triggering insulin production. Separation and purification of these peptide drugs are crucial to meet quality requirements, and the process requires careful consideration of factors such as column media selection, mobile phase pH and composition, flow rate, temperature, and gradient elution techniques. The NanoPak-C All-Carbon reverse phase media offers pH stability and unique selectivity for sustainable separation of peptides, providing flexibility in method development for the separation and purification of semaglutide and liraglutide. https://lnkd.in/dR2GTY-K

Buy Our High-quality Custom Peptide Synthesis At Best Prices https://lnkd.in/dfCSThqu #peptidessynthesis #CRO #ClinicalResearchOrganization #BioAnalyticals #BioEquivalence #ClinicalStudies #MethodDevelopment #Impurities #peptides #customsynthesisproducts #customsynthesis