Christopher Bunick’s Post

#Cell_Therapy_Instrument Market To Set Phenomenal Growth In Key Regions By 2023–2032 >> https://lnkd.in/d8s7ungD Cell #therapy is the emerging therapy involving #transplantation of cellular #material by injecting or grafting into the #patient's body to restore the function of the #particular tissue or #organ. Various instruments are used to carry out #cell therapy to cure diabetes, some #cancer types, neurological #disorders, and related #injuries. BD Biosciences Danaher Corporation GE Lonza Merck KGaA Pharmaceutical Miltenyi Biotec Sartorius STEMCELL Technologies Terumo Medical Corporation Thermo Fisher Scientific #pharmaceuticalindustry #healthcareresearch #celltherapy #transplantation #neurological #cellular 

Eleva uses its proprietary moss cell culture (Bryotechnology) to produce highly complex and difficult to express biopharmaceuticals with optimized human-like glycosylation. The first moss-based protein has been successfully tested in a clinical trial. RPV-001: recombinant alpha-galactosidase enzyme for the treatment of Fabry disease as an enzyme replacement therapy, clinical safety confirmed in phase I study. CPV-104: extensive pre-clinical testing completed (dry AMD, PNH, C3G, ANCA, lupus nephritis), toxicity studies ongoing, potential treatment for multiple complement indications. Bryotechnology provides a highly robust production platform that can be run in state-of-the-art bioreactors over a wide range of temperature and pH conditions. Stability, consistency, and homogeneity of N-glycosylation are remarkable and less affected by process conditions and scale. The GMP-compliant system is easily transferable and is known for its batch-to-batch stability and safety. By using simple culture media and avoiding virus filtration systems, even challenging proteins can be produced in a cost-effective manner. The platform is available for out-licensing. The Eleva team is eager to tackle the most challenging molecules. We welcome your enquiries regarding strategic partnerships, collaborations, co-development, and licensing of RPV-001, CPV-104 and the Bryotechnology platform. Meet eleva @ #Sachs_ELSF More Info @ https://lnkd.in/dQWhKYkV #ELSF2024 #LifeSciences #Biotech #BioPharma #Partnering #Investment #Startups #RisingStars #Oncology #Neurology #Genomics #Immunotherapy #CNS #Autoimmune #Cardiovascular #BiotechIndustry #BioTechInvestment #Innovation #InvestmentForum #SachsSpringLifeSciencesWeek #SSLSW

New Study: ExoPTEN with siRNA from a new GMP-compliant partner effectively targeted damaged spinal cord tissue in a preclinical study. This highlights ExoPTEN's potential as a therapy for acute spinal cord injuries and marks another step towards scaling up! #ExosomeTechnology #SpinalCordInjury #PrecisionMedicine #RegenerativeMedicine #NanodrugDelivery #ScalingUp https://lnkd.in/decBhcr9

AM-411 is Altamira Therapeutics' groundbreaking candidate for the treatment of #rheumatoidarthritis. An intraveneously administered nanoparticle based on the OligoPhore™ platform, AM-411 targets p65, one of the main transcriptional regulators of the NF-kB pathway and a key checkpoint in #RA inflammation What are the key differentiating factors of AM-411? - Reduced systemic side effects: Mediators of inflammation play many physiological roles in healthy tissues – AM-411 targets only inflamed tissues - Less likelihood of resistance: Blocking production of an NF-κB component by degrading mRNA to cause less resistance than inhibition of NF-κB Discover more as Altamira hopes to transform treatment paradigms for partients battling RA: https://bit.ly/3JjIBix #Science #RNADelivery #siRNA #mRNA #RNATherapeutics

#Clinical_Trials Market Growing Popularity and Emerging Trends 2022 to 2030 >> https://lnkd.in/gAEMSk_i Clinical Trials Packing Services The Clinical Trials Guru, LLC Clinical Trials Transformation Initiative (CTTI) Clinical Trials of Texas, A Flourish Research Site The Clinical Trials Network, (CTNx) Clinical Trials Arena Clinical Trials BC Clinical Trials Centre, The University of Hong Kong Clinical Trials Ontario Clinical Trials Team Clinical Trials Series Worldwide Clinical Trials Applied Clinical Trials Magazine Alliance for Clinical Trials in Oncology Global Clinical Trials (GCT) Jeeva Clinical Trials Inc. Atlantia Clinical Trials CTMA - Clinical Trials Mobile Application UW Clinical Trials Institute SPRI Clinical Trials Verified Clinical Trials Outsourcing in Clinical Trials Event Series LabCorp Clinical Trials ClinCloud Clinical Trials Aotearoa Clinical Trials Sonic Clinical Trials NHMRC Clinical Trials Centre Optimal Clinical Trials Multi-Regional Clinical Trials Center of Brigham and Women's Hospital and Harvard (MRCT Center) Institute of Clinical Trials and Methodology at UCL Merck Clinical Trials Institute for Advanced Clinical Trials for Children (I-ACT for Children) Archives of Clinical Trials and Case Reports UniSC Clinical Trials Cyntegrity | Data Science for Clinical Trials The Prostate Cancer Clinical Trials Consortium (PCCTC) High Point Clinical Trials Center Portugal Clinical Trials Clinical Supply Leader Clinical Research Associates, Inc #clinical #disease #treatment #drugs #drug #surgery #therapy #clinicaltrials #clinicalresearch #clinicalpharmacy #clinicaldevelopment #diseaseprevention

#Clinical_Trials Market Growing Popularity and Emerging Trends 2022 to 2030 >> https://lnkd.in/gAEMSk_i Great Lakes Clinical Trials, A Flourish Research Site Clinical ink European & Developing Countries Clinical Trials Partnership Worthwhile Clinical Trials SA Australian Clinical Trials Alliance Mobile Tech in Clinical Trials Clinical Research Management, Inc. (ClinicalRM) DPHARM: Disruptive Innovations to Advance Clinical Trials Clinical Research Partners Clinical Site Partners, LLC - A Flourish Research Site Clinical Research Society of Kenya Clinical Research Network India Clinical Pharmacology Study Group Clinical Research Unit at The Neuro Clinical.ly LB Research srl - Clinical Trials Management Canadian Centre for Clinical Trials Clinical Trial Research Services Clinical Research Center (CRC) at CCHE 57357 Clinical Trial Data Services CTAD Clinical Trials on Alzheimer's Disease Clinical Research News Clinical Development Solutions The Association of Diversity in Clinical Trials Clinical Trial Center (CTC) - Erasmus MC Clinical Trial Endpoint (CTEP) Clinical Trial Consulting Clinical Research Strategies, LLC The Clinical Informatics Research Unit Clinical Consulting Poland Clinical Accelerator Clinical Best Solutions - clinical trials center. Clinical Trial Service B.V. Trials.ai Yuma Clinical Trials Parexel Quest Diagnostics Covance #clinical #disease #treatment #drugs #drug #surgery #therapy #clinicaltrials #clinicalresearch #clinicalpharmacy #clinicaldevelopment #diseaseprevention

Check out our newest publication in OARSI!

𝗡𝗼𝘀𝗲-𝘁𝗼 𝗕𝗿𝗮𝗶𝗻 𝗗𝗲𝗹𝗶𝘃𝗲𝗿𝘆 𝗼𝗳 𝗥𝗲𝘀𝘃𝗲𝗿𝗮𝘁𝗿𝗼𝗹, 𝗮 𝗡𝗼𝗻-𝗜𝗻𝘃𝗮𝘀𝗶𝘃𝗲 𝗠𝗲𝘁𝗵𝗼𝗱 𝗳𝗼𝗿 𝘁𝗵𝗲 𝗧𝗿𝗲𝗮𝘁𝗺𝗲𝗻𝘁 𝗼𝗳 𝗖𝗲𝗿𝗲𝗯𝗿𝗮𝗹 𝗜𝘀𝗰𝗵𝗲𝗺𝗶𝗮 Cerebral ischemia represents a particular condition among neurological diseases due to its high frequency, high associated mortality, and the permanent disability in patients that survive it. Numerous studies in animal models have demonstrated the protective properties of resveratrol against cerebral ischemia. Resveratrol is a soluble molecule in polar solvents with high membrane permeability; however, it is rapidly metabolized at the liver and is also a substrate of the ATP binding cassette transporters located at the blood–brain barrier. These circumstances reduced bioavailability of resveratrol to the brain. In this review, we examined nasal resveratrol’s formulations including nanocarriers such as nanostructured lipid carriers, nanoemulsions, nanoparticles, bilosomes, cubosomal, and transferosomes that are directly transported to the brain. #pharmaceutical #LipidNanoparticles #nanoemulsion

VMAT structures reveal exciting targets for drug development Vesicular monoamine transporter (VMAT)-2 has a crucial role in the neurotransmission of biogenic amines. Recently, Dalton et al., Pidathala et al., Wu et al., and Wang et al. individually reported cryo-electron microscopy (EM) structures of human VMAT2, offering opportunities for developing improved therapeutics and deep insights into the functioning of this protein. VMATs actively remove monoamines, such as serotonin, dopamine, histamine, adrenaline, and noradrenaline, from the cytosol. These monoamines are stored in synaptic vesicles at nerve terminals or storage organelles found in platelets, enterochromaffin, chromaffin, and other similar cells. This storage process is essential for regulating the release of neurotransmitters into the synaptic cleft or to appropriate targets throughout the human body. In humans, mutations in VMATs can lead to developmental delay, dystonia, parkinsonism, and increased mortality, highlighting the importance of these transporters in neurotransmission. VMATs are also a target for treating hypertension, psychotic agitation, psychostimulant abuse, and hyperkinetic movement disorders, such as Huntington's disease-related chorea. Despite their physiological and pharmacological significance, the structural basis for substrate recognition and inhibition by different drugs was unknown until recently. Four publications reported cryo-EM structures of VMAT2 in different conformations, bound to substrates and inhibitors. https://lnkd.in/dN3EM4yv

#Clinical_Trials Market Growing Popularity and Emerging Trends 2022 to 2030 >> https://lnkd.in/gAEMSk_i The #clinical trials are the research #investigation that finds new ways to prevent, #diagnose or treat #disease. It's the final step in a long process. Where new #drugs, new approaches to #surgery or radiation #therapy, and advances in new areas such as gene #therapy is investigated. #Testing of #treatment or drug is done in steps called phases. IQVIA, PAREXEL International (India) Private Ltd, Pharmaceutical Product Development, LLC, Charles River Laboratories, ICON plc, WuXi AppTec, SGS, Syneos Health, CHILTERN INTERNATIONAL LIMITED, Eli Lilly and Company, Novo Nordisk Pharmatech A/S/, Pfizer, Clinipace #clinical #disease #treatment #drugs #drug #surgery #therapy #clinicaltrials #clinicalresearch #clinicalpharmacy #clinicaldevelopment #diseaseprevention