Clene Nanomedicine, Inc.’s Post

We are glad to share a recent paper from the long standing collaboration of Fintan Moriarty with ARI former medical fellow Willem-Jan Metsemakers, MD, PhD. The work, involving also ARI’s preclinical and Biomedical Materials teams, investigates delivery systems for antibiotics and bacteriophages. Read more at https://lnkd.in/e8bP2rv4  

Check out the recent Bruker BioSpin “customer insight” article, “Imaging Serves as a Scientific Hub to Unite Preclinical and Clinical Research,” to learn how Prof. Chris Flask, PhD, and his team are uniting #preclinical and #clinical research in The Case Center for #Imaging Research at #CWRU! Download the article here: https://lnkd.in/e3uYxA5r

https://lnkd.in/gDieBSJa DRAGEN v4.3 is launching, with notable accuracy gains AND built-in mosaic calling. Quoting from some of the release material: Broad Clinical Labs has been systematically researching the accuracy of variant calls made by DRAGEN v4.3. Marina DiStefano, PhD, FACMG, associate lab director at Broad Clinical Labs, said: "We generated whole-genome sequence data from samples with confirmed calls in genes covered by DRAGEN v4.3 specialized callers, such as PMS2, NEB, and HBA, and from samples with orthogonally confirmed CNV calls. We also analyzed very-high-coverage WGS samples for mosaic evaluation. We are happy with the accuracy and speed and believe that DRAGEN v4.3 is a powerful tool for our clinical whole-genome research."

I highly recommend this webinar for those interested in moving compounds to IND using predictive retina models

I highly recommend this webinar to all interested in drug discovery and development!

Highlight new research in an area of clinical pharmaocology and translational science that you are passionate about in your session proposal for #ASCPT2025: https://bit.ly/2JHcTu7

Just published in Bioelectronic Medicine: https://lnkd.in/darDvT2 TRPV1 nociceptors are required to optimize antigen-specific primary antibody responses to novel antigens Aisling Tynan, Téa Tsaava, Manojkumar Gunasekaran, Carlos E. Bravo Iñiguez MD,PhD, Michael Brines, Sangeeta Chavan & Kevin Tracey https://lnkd.in/ehFUm3nj Submit your best science to Bioelectronic Medicine!

📢 Publication highlight! 📢 We are thrilled to highlight a publication from Nature's Scientific Reports: "Nilotinib-induced alterations in endothelial cell function recapitulate clinical vascular phenotypes independent of ABL1." Key Takeaways: The study reveals that Nilotinib affects endothelial cell function, reducing their proliferation and migration, and increasing intracellular nitric oxide. The adverse vascular effects of Nilotinib are independent of ABL1, suggesting off-target mechanisms. 🔬 B8 Media, exclusively commercialized by Defined Bioscience, was pivotal in this research. It supported the differentiation and growth of hiPSCs, enabling accurate modeling of endothelial cell responses to Nilotinib. We are proud to contribute to understanding the mechanisms behind drug-induced vascular effects and look forward to further innovations in precision medicine. 👉 Read the full paper here: https://lnkd.in/eKDsER4K #StemCellResearch #CardiovascularResearch #DefinedBioscience #HiDefB8 #iPSC #hiPSC

Our scientists are at the forefront of research and development. We're proud to share three new scientific research articles that demonstrate how we bring innovation to the complex and evolving landscape of bioanalysis. Click on the below links to learn more! 1. Quantifying siRNA in Biological Samples Using a Novel Hybrid LC-MS/MS Method: https://lnkd.in/gWMreTfP 2. Accurate Quantification of ASOs in Mouse Serum Using Microsampling LC-MS/MS: https://lnkd.in/gSHyxVFK 3. Microsampling for Pediatric Baricitinib Pharmacokinetics: https://lnkd.in/gQNkwZP5 #DrugDevelopment #LCMS #Microsampling

Check out this introductory video as part of an In Focus feature sponsored by PromoCell. We explore angiogenesis as a strategy for tissue repair and regeneration and delve further into the challenges of translating this research to a clinical setting >>> https://bit.ly/4cczfAP