Cloudbreak Pharma’s Post

Daily Critical Care Pearls #48: Sugammadex 📌 It was designed to bind rocuronium and vecuronium to reverse paralysis from these neuromuscular blocking medications in adults undergoing surgery or patients unable to wean from the ventilator 📌 Unlike neostigmine (which also reverses neuromuscular blockers), sugammadex does not inhibit acetylcholinesterase --> cholinergic effects are not produced and glycopyrrolate or atropine does not need to be coadministered 📌 Sugammadex is faster than neostigmine and has less side effects according to a Cochrane review (but more costly) 📌  Dosing: To reverse moderate blockade from vec/roc: 2mg/kg IV x1 Deep blockade from vec/roc: 4 mg/kg IV x1 Immediate reversal of roc: 16 mg/kg IV x1. #criricalcare #pharmacy #medicine #clinicalpharmacy #pearls

💉 Sugammadex is a modified gamma-cyclodextrin designed for optimal encapsulation of the neuromuscular blocking drug rocuronium, preventing rocuronium from acting at the acetylcholine receptor. Sugammadex is used to reverse steroidal non-depolarizing neuromuscular blocking drugs rocuronium and vecuronium. ⚠️ Administration of sugammadex from 2 mg/kg to 16 mg/kg demonstrates a linear and dose-dependent pharmacokinetic relationship, with an elimination half-life of 100 to 150 minutes and near 100% renal clearance. ⛔ The most commonly reported adverse reactions after sugammadex administration is nausea and vomiting, headache, itching, procedural pain, and dysgeusia. Bradycardia has been noted after sugammadex administration, with some reports of cardiac arrest. 🔸 Anticholinergics such as atropine have been administered to counteract marked bradycardia and prevent cardiovascular collapse. It is recommended that vasoactive drugs such as epinephrine and atropine be available whenever sugammadex is administered. 🟢 For amazing clinical pearls, you can join my WhatsApp group: 👇🏻 https://lnkd.in/d3axttDk 🔴 You can also follow me on "YouTube and Instagram" as well: YouTube👉🏼: https://lnkd.in/d4Fx3vCr Instagram👉🏼: https://lnkd.in/dy6krB4q #meded #icucare #icupearls #pharmacology #clinicalpharmacist #clinicalpharmacology #hospitalpharmacy #NMBs #clinicalpearls

Email feedback based on social norms is an effective and light-touch intervention for increasing guideline-concordant opioid prescribing after surgery according to this randomized clinical trial. https://ja.ma/49TMWEc

Platelet-rich plasma (PRP) therapy has emerged as a groundbreaking treatment for alleviating joint pain and promoting tissue healing. By harnessing the regenerative properties of platelets found in the patient's blood, PRP therapy offers a natural and effective solution for individuals seeking relief from joint pain without resorting to surgery or prolonged medication use. In this article, we'll delve into the power of platelets and how PRP therapy can transform the management of joint pain. Read the full article: https://lnkd.in/e7K-rjCH

For patients with NASH, which is more effective: bariatric-metabolic surgery or lifestyle modification and optimized medical therapy? We summarize results of a study in Lancet https://lnkd.in/eqcrT3fp #EvidenceMatters #obesity #bariatricsurgery #fattyliver

Email feedback based on social norms is an effective and light-touch intervention for increasing guideline-concordant opioid prescribing after surgery according to this randomized clinical trial. https://ja.ma/3VkFFJ5

Evidence demonstrates that when discs identified by Nociscan are treated as part of the surgical strategy, patients experience a significantly greater success rate following surgery for chronic low back pain. To learn more about the evidence supporting the use of Nociscan to inform treatment decisions for low back pain, visit https://lnkd.in/gWQiz8kv. #ACON #ACONW #nasdaq #chroniclowbackpain #spinesurgery #clinicalevidence #clinicaldata

Are you taking into account the influence of bariatric surgery on drug absorption in your patient care? I recently contributed to 'Losing Weight, Gaining Life,' a book offering insights on overcoming obesity. Specifically, my chapter focuses on drug absorption after bariatric surgery. Drawing on my extensive experience in patient care over the years, I recognize the significance of comprehending these alterations and integrating them into clinical practice. I'd love to hear your thoughts and if you're incorporating these insights into your practice. #bariatricsurgery #medicationsafety

This year's Mason Lecture at American Society For Metabolic And Bariatric Surgery (ASMBS) was one to remember by, the one and only, Dr. Paulina Salminen. Amazing work conducted via the #SLEEVEPASS trial and this wonderful #calculator was developed utilizing merged data from the two large randomized clinical trials; the #Finnish SLEEVEPASS and #Swiss #SMBOSS trials. A great resource to evaluate treatment outcomes in #metabolic #bariatric #surgery as well as obesity-management medications. #ASMBS #RCT #OutcomesData #WLS #OMM #Medtronic #MedtronicEmployee https://lnkd.in/g6duH4q3

Questions about managing patients on psoriasis biologics who are undergoing surgery??? Check out my short piece featured on Project LEAD addressing this common question! https://lnkd.in/dERu6Czt