Cogstate’s Post

Our #Alto #digitalSPR platform played a crucial role in the development of DART.2 (Drug Acutely Restricted by Tethering), an innovative method for highly targeted #drugdelivery to specific types of neurons in the brain. Led by Dr. Mike Tadross at Duke University DART.2 has the potential to revolutionize how we study and treat #neurological diseases. By using Alto, researchers were able to precisely measure the binding kinetics of key molecules, ensuring the effectiveness of DART.2. We’re proud to support cutting-edge research with our next-gen #SPR platforms, enabling scientists to push the boundaries of what's possible in #drugdiscovery and #neuroscience. Read the full blog post here: https://lnkd.in/gpYitjSA

⏰ It's not too late to register! You won't want to miss our webinar, "iForum™ Innovation Showcase 2024: Implementing Human iPSC Models to Speed Drug Discovery and Improve Clinical Translation" on January 30, 2024 (9:00 AM- 11:00 AM EST). Join us as FCDI's leading scientists dive into the transformative power of advanced biological models. We're talking about breakthroughs that are reshaping our approach to accelerating drug discovery across cardiac, hepatic, neural, and immune systems. Come for specific talks or immerse yourself in the entire 2-hour presentation – the choice is yours! 👉 VIEW DETAILED AGENDA AND REGISTER NOW! https://ow.ly/vupM50Qs8sP #StemCells #iPSC #DrugDiscovery #DrugDevelopment #Neuroscience #DiseaseModeling #3DCellCuture #Neuroinflammation #SafetyPharmacology #CardiacSafety #CardioTox

🌟💬 Xtalks Spotlight: To learn why companies developing treatments for #Alzheimer’s disease should consider including EEG biomarkers in clinical studies, Xtalks spoke with Christopher (CJ) Barnum PhD, VP of CNS Development at INmune Bio Inc. and Brian Murphy, PhD, Co-Founder and Chief Scientific Officer of Cumulus Neuroscience. 🧠 Watch the full interview with Dr. Barnum and Dr. Murphy here: https://buff.ly/3VYUfX3 #CNSTrials #DigitalBiomarker #DigitalBiomarkers #XtalksSpotlight #NeuroscienceTrials #NeuroscienceClinicalTrials #CNSDrugDevelopment #AlzheimersDiseaseTrials #NeurodegenerativeDisease

Ekaterina Lunkova, Jen-Kai Chen, Rajeet Singh Saluja, and Alain Ptito from McGill University have conducted a study assessing oculomotor functions as potential biomarkers for mild traumatic brain injury (mTBI). Key findings include: 1 - Oculomotor Deficits : Concussed subjects displayed significant differences in anti-saccades and optokinetic nystagmus (OKN) performance compared to healthy controls. 2 - Abnormal Activation Patterns : Increased blood oxygen level-dependent (BOLD) signal changes were observed in brain regions associated with oculomotor regulation, suggesting disruptions due to concussion. 3 - Promising Biomarkers : Anti-saccades and OKN tasks demonstrated high sensitivity in detecting mTBI, highlighting the potential of oculomotor assessments in diagnosing concussions. This research underscores the value of noninvasive, rapid eye-tracking systems in mTBI diagnosis, offering a feasible alternative to functional MRI in clinical and field settings when this imagery is unavailable. #BrainInjury #Oculomotor #Biomarkers #Neuroscience #mTBI #ConcussionResearch #Neurotrauma #EyeTracking #FMRI

⏰WEBINAR - Last Chance to Register! Join us on October 23, 2024 (11:00 AM EST) for our webinar, "Scientific Shorts: Neuroscience 2024 Poster Recap with New iPSC-derived Cell Types and Applications". ✔️LEARN MORE AND REGISTER NOW! https://ow.ly/LkcU50TL7km During this webinar, we will review the exciting scientific research FCDI presented at Neuroscience 2024 as four 10-minute talks. Key topics include: ✔️Optimization of cytokine release assays for iCell® Microglia and the role of healthy microglia and TREM2 variants in neuroprotection and neurodegeneration. (Michelle Curtis) ✔️Assays to evaluate iCell Sensory Neurons function and techniques to investigate immune-mediated neuropathic pain and CIPN. (Scott Schachtele) ✔️Assessment of the BBB for drug permeability and disease studies in a high-throughput fashion using the iCell Blood-Brain Barrier Kit. (Ravi Vaidyanathan) ✔️Using Agilent Seahorse XF to detect differences in mitochondrial function between various healthy and diseased iCell neural products. (Coby Carlson) Can't attend live? Not a problem! All registrants will receive access to the recording post-webinar. We hope to see you there! #neuroscience #drugdiscovery #iPSC #diseasemodeling #bloodbrainbarrier #neurodegeneration #painresearch #neuropathy

💡 🎙️ ICYMI: Tune in to the latest episode of the Xtalks Life Science Podcast with Dr. Alessio Travaglia, Neuroscientist and Director Neuroscience at FNIH, and Dr. Suzanne Schindler, MD, PhD, Associate Professor of Neurology about a study showing that some diagnostic blood tests are accurate enough to diagnose #Alzheimer’s, potentially replacing CSF tests and PET scans. This breakthrough could save patients both cost and discomfort, while improving clinical trials and drug development. 🎧 Listen to the full episode on the promise of blood tests for Alzheimer’s diagnosis: https://buff.ly/3yWJ3RP #Dementia #AlzheimersDisease #Biomarkers #NeurodegenerativeDiseases #LifeSciencePodcast #NeurologicalDiseases #BloodTests

Harvard's Wyss Institute has developed a groundbreaking assay for early Parkinson's Disease detection. It's a key step towards better understanding and a potential cure for this condition. Early diagnosis means better understanding of the disease and may give clues to better treatment strategies and research advancements towards a cure. #ParkinsonsDisease #EarlyDetection #MedicalInnovation #Neuroscience #HealthcareBreakthrough #HopeForCure #ResearchAdvancement For more details, read the full article https://lnkd.in/gRpwU2NA

⏰ Missed FCDI at #SfN24? We have you covered! Join us on October 23, 2024 (11:00 AM EST) for our webinar, Scientific Shorts: Neuroscience 2024 Poster Recap with New iPSC-derived Cell Types and Applications. ⭐Learn more and register now! https://ow.ly/LkcU50TL7km During this webinar, we will review the exciting scientific research FCDI presented at Neuroscience 2024 as four 10-minute talks. Key topics include: ✔️Optimization of cytokine release assays for iCell® Microglia and the role of healthy microglia and TREM2 variants in neuroprotection and neurodegeneration. ✔️Assays to evaluate iCell Sensory Neurons function and techniques to investigate immune-mediated neuropathic pain and CIPN. ✔️Assessment of the BBB for drug permeability and disease studies in a high-throughput fashion using the iCell Blood-Brain Barrier Kit. ✔️Using Agilent Seahorse XF to detect differences in mitochondrial function between various healthy and diseased iCell neural products. Can't attend live? Not a problem! All registrants will receive access to the recording post-webinar. We hope to see you there! #neuroscience #drugdiscovery #iPSC #diseasemodeling #bloodbrainbarrier #neurodegeneration #painresearch #neuropathy

Delphi-MD Revolutionizes Parkinson's Diffrencial Diagnosis! We’re thrilled to announce a major breakthrough in the diagnosis and subtyping of Parkinson’s disease! Published in Nature's npj Parkinson's Disease, our Delphi-MD device leverages novel electrophysiological imaging to provide real-time brain health assesment, enabling precise diagnostics and streamlines improved, personalized treatment. This is a first in neurological care, empowering clinicians to intervene earlier and more effectively! To read the full release: link here > https://lnkd.in/d4VQGKz2 To learn more about Delphi-MD : www.quantalx.com #Parkinsons #Neurodiagnostics #DelphiMD #QuantalX #PersonalizedMedicine #NeuroScience

Chronic pain impacts millions, diminishing their quality of life and daily experiences. At Neuroservices-Alliance, we stand with patients, healthcare professionals, and global organizations to spotlight the challenges of living with chronic pain. Our commitment to advancing pain research is reflected in our comprehensive range of assays: 🔹 Spinal Cord Slices 🔹 Dorsal Root Ganglia (DRGs) 🔹 Human iPSC- derived sensory neurons 🔹 In Vivo Models (Anesthetized Mice) Learn more about our pioneering research and how we contribute to understanding and treating pain conditions at https://lnkd.in/gnHGA6V5 ✉️ Reach out to find out how we can support your pain research projects: https://lnkd.in/g8_xmiXw #Painawarenessmonth #painresearch #neuroscience #research