📢 Peptide chemists across the globe all have their own opinions on the most important factor of peptide synthesis. ⚗ Some say synthesis purity, while others argue for synthesis speed or minimizing waste. Check out this article to better understand what drives peptide synthesis purity, speed, and waste generation: https://lnkd.in/gxXZK6KG Which side are you on? 🤔 🔎 #PeptideSynthesizers #HeatedSynthesis #GreenChemistry #PeptideSynthesis #ScienceReads
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https://lnkd.in/gV7awgAa Article Title: Chemical and physical stability of selected drugs for aerosol therapy with Sirmione thermal water Author(s): Francesco Saverio Robustelli della Cuna, Carlo Sturani, Sarah Galfrè, Luisa Gervasio, Cristina Sottani and Elena Grignani Journal: Open Journal of Chemistry Journal ISSN: 2641-3051 Abstract: In this work, we investigated the chemical and physical stability of ambroxol, beclomethasone dipropionate, budesonide and N-acetylcysteine after dilution with Sirmione thermal water, stored in ampoules for aerosol, at room temperature. The chemical stability of all active drugs was evaluated by Ultra-High-Performance Liquid Chromatography tandem mass spectrometry (UHPLC/MS/MS). All samples were analyzed in triplicate at room temperature under normal fluorescent light at 0h, 1h, 6h, 12h, and 24 h. According to the Official Pharmacopoeia of the Italian Republic, the degradation of a molecule that exceeds more than 10% is considered unacceptable. After dilution with thermal water of Sirmione, ambroxol, beclomethasone dipropionate, budesonide, and N-acetylcysteine, were found to be physically stable over the entire study (degradation <3%) at room temperature without any loss of activity. #Sirmionethermalwater #Ambroxol #Beclomethasonedipropionate #Budesonide #Nacetylcysteine #Stability #Chemistry #OrganicChemistry #InorganicChemistry #PhysicalChemistry #AnalyticalChemistry #Biochemistry #TheoreticalChemistry #EnvironmentalChemistry #ChemicalEngineering #Peertechz #PeertechzPublications #PolymerChemistry #MedicinalChemistry #IndustrialChemistry #GreenChemistry #ChemicalSynthesis #ChemicalKinetics #Spectroscopy #Electrochemistry #Nanochemistry #SurfaceChemistry #QuantumChemistry #ChemicalBonding #Thermodynamics #ChemicalCatalysis #SupramolecularChemistry #MaterialsChemistry
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If you missed our earlier post today we are excited to introduce the revolutionary PS-30 pilot scale peptide synthesizer. 🎉 Fast-Flow peptide synthesis combines the benefits of continuous flow with the robustness of Fmoc/tBu solid-phase peptide synthesis offering peptide chemists: ☑️ Synthesis scale 2.0 mmol to 30.0 mmol ☑️ Typical reaction time for a 30-mer peptide at 20 mmol scale is 16 hours ☑️ Fmoc solid phase peptide chemistry with DIC and oxyma activation ☑️ Continuous in-line analytics including resin solvation data and UV absorption data ☑️ State-of-the-art peptide synthesis software including sequence generator with automated addition of side chain(s) and real time analysis of synthesis quality ☑️ Minimises solvent and reagent usage. Solvent usage typically less than 70 ml per mmol / cycle even when using PEG resin Want to find out more? Click here https://bit.ly/3vF3D71 #FlowChemistry #PeptideChemists #ProductLaunch #PeptideTherapeutics
Peptide-Pilot - Vapourtec
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ACS Medicinal Chemistry Letters Most Read Articles - Transforming Therapeutic Approaches with PROTAC Technology: New Targets and Potentials (https://lnkd.in/gnX_K3Zp) Description: Most Read articles are refreshed daily and based on full text downloads (PDF and HTML) from the previous 30 days and 12 months. https://lnkd.in/gUqbUhP9
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Early detection of 4-ethylphenyl sulfate (4-EPS), a gut microbial metabolite, in bodily fluids has huge implication in neurological and developmental disorders such as autism spectrum disorder (ASD). https://lnkd.in/g4xuc6ZF Our latest paper about the new method to detect 4‑ethylphenyl sulfate with enhanced sensitivity. #science #biotechnology #bioscience #microbiome #microbiology #metabolite #gutmicrobiome #gut #microbiota #biology #csir #drdo #dbt #dst #pharmaceutical #microbial #drugdiscovery #drugdevelopment #Biochemistry #biotech #biology #chemistry #college
4-Ethylphenyl Sulfate Detection by an Electrochemical Sensor Based on a MoS2 Nanosheet-Modified Molecularly Imprinted Biopolymer
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Click Chemistry in Peptide Synthesis https://lnkd.in/gffjD5UX
Click Chemistry in Peptide Synthesis
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When selecting a biochemistry analyzer, understanding the price significance is crucial; it enables laboratories to balance financial constraints with the necessity for accurate and efficient testing. Check: https://lnkd.in/d_hsd7yx #BiochemistryAnalyzer #BiochemistryAnalyzers #Biochemistry #BloodTest #PathologyTest #PathologyLabTest #LabTest #Labtesting #BloodTesting #PathologyLab #Lab #drlogy #drlogyplus #BloodAnalyzer #PathologyLabMachine #LabMachines #LabEquipment #PathologyLabEquipment #laboratory #doctors #doctor #diagnostics #diagnostic #diagnosticservices #pathologylaboratory #laboratory
Biochemistry Analyzer Price - Drlogy
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Protein #NMR, isotope labeling and chemical shift calculations form the basis for a rapid and efficient structure optimization process of initial low-affinity binders. A recent research article published in the Journal of Medicinal Chemistry presents the latest findings from a collaborative project involving the University of Vienna, Boehringer Ingelheim, and MAG-LAB, with financial support from the Christian Doppler Society. This innovative method employs protein NMR spectroscopy, combined with aliphatic residue methyl labeling to directly measure CH-hydrogen bonding interactions. The resulting data on ligand-protein complex geometries helps to understand the residual mobility of ligands within their binding pockets, indirectly reflecting binding energies. These insights enable medicinal chemists to make well-informed decisions during accelerated structure optimization processes, even in the absence of protein-ligand cocrystal structures. Read the full story in the open access article: https://lnkd.in/dNfVS8fu
Probing Protein–Ligand Methyl−π Interaction Geometries through Chemical Shift Measurements of Selectively Labeled Methyl Groups
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🙋Effortlessly analyze biological samples with infitek Fully Automatic Biochemistry Analyzer, BA-A-120—Constant 120 test / hour with double reagent. Simplify lab operations!#BiochemistryAnalyzer#LabDevices #infitek#
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KHB ZY-1200 Fully Automatic Clinical Chemistry Analyzer • 180 sample capacity & 200 reagent capacity, designed for medium and large clinical laboratories • Working speed 800 tests/hour • Dual-channel batch sample input • Heating method: Liquid bath 37 ±0.1℃ • Wavelength: 16 wavelengths, 340 ~ 800nm • Open system. Can be matched with KHB’s extensive Clinical Chemistry Testing Menu or other manufactures’ reagents #KHB ZY-1200 has a larger sample size and more reagent positions. The detection is more efficient, convenient and reliable. ZY-1200 redefines 800T/H biochemistry analysis system. Learn more: https://lnkd.in/g9Kaq9cU #Biotech #IVD #Diagnostics #Biochemistry #ClinicalChemistry #Analyzer
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Principles of Fluorescence Techniques Workshop SIGN UP TODAY! Register here: https://lnkd.in/gBcbgWrs #fluorescence #fluorescenceprinciples #fluorescenceworkshop #fluorescencetechniques #steadystatefluorescence #timeresolvedfluorescence #anisotropy #timeresolvedspectra #confocal #confocalmicroscopy #fluorescencemicroscopy #ffs #fluorescencefluctuationspectroscopy #spectroscopy #particletracking #singlemoleculeimaging #STED #superresolutiontechniques #stem #stemlearning #lifesciences #stemeducation #chemistry #materialscience #pharma #phasorplots
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