Cure Alzheimer's Fund’s Post

Cure Alzheimer's Fund enables research designed to increase our understanding of the underlying pathology of Alzheimer's and how that might lead to novel targets for therapeutics. Meaning, we fund research that explains what is going on in a person with Alzheimer's disease and how that information can lead to a new drug or intervention. In this study, Oleg Butovsky and his lab are changing the understanding of how immune cells impact Alzheimer's and how female carriers of APOE4 may be at greatest risk. Read more in the link. #alzheimers #research #alzheimersdisease

Women are roughly twice as likely as men to develop Alzheimer’s disease, and the risk is even greater for women carrying one or both copies of the APOE4 gene. Findings from Dr. Butovsky and Dr. Rosenzweig at Brigham and Women’s Hospital reveal a possible explanation behind this vulnerability. Their research shows that in APOE4 carriers, neutrophils—immune cells typically found outside the brain—can infiltrate the brain and disrupt microglia, the brain’s primary immune cells. This interference prevents microglia from effectively performing their protective roles. Understanding the harmful interaction between neutrophils and microglia offers a promising avenue for interventions tailored to high-risk women with APOE4.

Jake Rubens, the CEO and a co-founder of Quotient Therapeutics is quoted in this article in The Atlantic that delves into the impact somatic mutations can have in causing disease. The Quotient team has developed the world’s first Somatic Genomics platform which has the potential to identify intrinsically validated genes, proteins and pathways that can be used as targets for the development of transformative therapies in a wide range of indications. https://ow.ly/zERi50UCSfJ

What is Sickle Cell Trait (SCT)? Sickle Cell Trait (SCT) occurs when a person inherits one sickle cell gene and one normal gene. Unlike Sickle Cell Disease (SCD), people with SCT usually don’t have symptoms or health problems. However, they can pass the gene to their children, and in rare cases, SCT can lead to complications like extreme physical stress or dehydration. Knowing your sickle cell status is important for family planning and overall health. This September, during Sickle Cell Awareness Month, get informed, get tested, and help raise awareness. Let’s spread the word! #SickleCellAwareness #KnowYourStatus #SickleCellTrait #SickleCellMonth #HealthMatters #giveblood

An insightful article about the APOE4 gene risks for Alzheimer's disease based on a recent research paper published in Nature. You can read it via my friend link on Medium https://lnkd.in/gUN2xUuy

Thalassaemia is an inherited blood disorder that affects the body's ability to produce healthy red blood cells, and understanding your genetic makeup can protect your future family. How? A simple blood test. 🩸 The blood test can reveal whether you or your partner carry the thalassaemia gene, potentially impacting your children and help you to make informed decisions and take proactive steps to prevent passing it on. The test not only detects the risk of thalassaemia but also other inherited conditions, offering an extra layer of protection. 👩🏻🍼 Read the article to understand its full impact and what your options are to prevent it. https://lnkd.in/dEBkmjsh... #ThalassaemiaAwareness #GeneticScreening #FutureFamily #PreventiveHealth #ThalassaemiaTesting #IVFCare #NovaIVF #ReproductiveHealth Shriraj RawalNaresh Pandya Dr. Jayesh Amin

According to The ALS Association, about 90% of ALS cases occur without any known family history or genetic cause with the remaining 10% of ALS cases are inherited through a mutated gene with a known connection to the disease. Most people who develop ALS are between the ages of 40 and 70, with an average age of 55 at the time of diagnosis and men are 20% more likely to develop the disease than women. Learn more about the causes of ALS and raise awareness to #EndALS this #BrainAwarenessMonth here: https://lnkd.in/ew7rMt6. #EndALS #ALSresearch #CoyaTherapeutics

According to The ALS Association, about 90% of ALS cases occur without any known family history or genetic cause with the remaining 10% of ALS cases are inherited through a mutated gene with a known connection to the disease. Most people who develop ALS are between the ages of 40 and 70, with an average age of 55 at the time of diagnosis and men are 20% more likely to develop the disease than women. Learn more about the causes of ALS and raise awareness to #EndALS here: https://lnkd.in/ew7rMt6 #EndALS #ALSresearch #CoyaTherapeutics

What is Huntington's disease? Huntington's disease is an illness caused by a faulty gene in your DNA - the biological 'instructions' you inherit which tell your cells what to do. If you have Huntington's, it affects your body's nervous system - the network of nerve tissues in your brain and spinal cord that coordinate your body's activities. Although there is, as yet, no cure, you can learn to manage symptoms more effectively to improve your quality of life. For more information: https://loom.ly/Sx-WJL4

❓ Is a heterozygous variant of high pathogenicity with a reported recessive inheritance pattern sufficient to cause disease? ❓ What is the difference in predicting the likelihood of disease development when two pathogenic variants within a single gene are present on the same allele versus different alleles? What is compound heterozygosity? ✅ Learn how to resolve these complexities and how easy it is to obtain this information with the GeneSpect Hereditary Reporter → https://lnkd.in/gTff8DVV