Cytomos’ Post

Adenine base editors, such as ABE7.10, enable programmable C•G to T•A point mutations, but editing efficiencies can be low at challenging loci in primary human cells. 🧬 Discover how Beam Therapeutics leveraged DNA variant libraries of adenine base editors, synthesized by Ranomics, to evolve ABE7.10 into the ABE8s with superior editing performance 👉 https://lnkd.in/gAJCq7TJ #beamtherapeutics #crisprcas9 #geneediting #genetherapy #geneticengineering #dna

MicroRNA (miRNA) is a class of non-coding single-stranded RNA molecules with a length of about 22 nucleotides encoded by endogenous genes. They play an important role in the process of cell differentiation, biological development, and disease development. With in-depth research on the mechanism of miRNA, miRNA is expected to provide new ideas for diagnosis and drug discovery and development. GenCefe's experienced oligo synthesis technology team has developed various miRNA mimics for gain-of-function studies and inhibitors for loss-of-function studies, with different options for both in vitro and in vivo experiments. Get a free quote NOW: oligo@gencefebio.com #rnasynthesis #miRNA #microRNA #miRNAinhibitor #miRNAmimic

MicroRNA (miRNA) is a class of non-coding single-stranded RNA molecules with a length of about 22 nucleotides encoded by endogenous genes. They play an important role in the process of cell differentiation, biological development, and disease development. With in-depth research on the mechanism of miRNA, miRNA is expected to provide new ideas for diagnosis and drug discovery and development. #MicroRNA #miRNA #RNAsynthesis #syntheticbiology #Biotech

Network Medicines™ are a new class of therapeutic with the potential to transform the treatment of complex diseases that are driven by multicellular networks, such as #cancer and #fibrosis. They are designed to have both a direct effect by targeting diseased cells themselves and a network effect by reprogramming diseased cells to release therapeutic signals that coordinate other key cells in the network to restore health. Read more about Network Medicines as well as some of the other new science being pioneered by fellow #FlagshipFounded companies below. 

MicroRNA (miRNA) is a class of non-coding single-stranded RNA molecules with a length of about 22 nucleotides encoded by endogenous genes. They play an important role in the process of cell differentiation, biological development, and disease development. With in-depth research on the mechanism of miRNA, miRNA is expected to provide new ideas for diagnosis and drug discovery and development. GenCefe's experienced oligo synthesis technology team has developed various miRNA mimics for gain-of-function studies and inhibitors for loss-of-function studies, with different options for both in vitro and in vivo experiments. Get a free quote NOW: oligo@gencefebio.com #rnasynthesis #miRNA #microRNA #miRNAinhibitor #miRNAmimic

MP Biomedical’s LSM™ Lymphocyte Separation Medium is formulated for isolation of mononuclear cells from defibrinated or heparinized whole human blood, as well as blood from other species. * Fit for a wide range of cell types: PBMCs, Bone Marrow, Spleen cells, TILs, and more * Maximum yield of mononuclear cells * Easy one-step centrifugation * > 96% cell viability of lymphocytes * Non-toxic to cells, low endotoxin levels * Compatible with different downstream applications See our article in Genetic Engineering & Biotechnology News about High-Performance Density Gradient Media for Purification of Leukocytes from Blood: https://lnkd.in/g5z9f9YQ

Join us on June 5th from 10:00-11:00 AM EST as Peter Oliver, PhD - Head of Biology at NATA - Nucleic Acid Therapy Accelerator and Carl Ascoli, BS, MS, PhD - CSO at Rockland, discuss breakthroughs in oligonucleotide drug delivery and detection. Learn how Rockland's ModDetect anti-PS and anti-MOE Panels are advancing RNA therapeutic research, overcoming drug delivery challenges, and improving ADMET profiling. 👉 Key Insights: - Application of ModDetect panels in RNA therapeutics - Challenges in efficient endosomal escape - Importance of rigorous testing for safety and efficacy - Opportunities for future research collaboration Don't miss out on expert insights into the future of nucleic acid therapies! #Webinar #Biotech #Oligonucleotide #RNAtherapeutics #DrugDelivery

In the ongoing battle against antibiotic-resistant bacteria, researchers are investigating innovative compounds to combat these challenging pathogens. A recent study highlights the potential of a compound called F8, designed using advanced drug design techniques and modular synthesis. The study employs a multifaceted approach, including in vitro and in vivo experiments, molecular docking studies, and multi-omics analysis. This comprehensive methodology aims to uncover how F8 interacts with bacterial cells and its specific target, arcB. Preliminary findings suggest that F8 targets the arcB gene, alters bacterial cell membrane permeability, and induces oxidative damage. It also demonstrates significant antimicrobial activity with low resistance development, superior binding affinity, and a competitive binding mechanism. These findings have the potential to drive the development of new antibiotics, offering promising solutions to tackle antibiotic-resistant bacteria. F8’s unique mechanisms provide valuable insights for future clinical applications and underscore the importance of innovative approaches in antimicrobial research. #AntibacterialResearch #AntibioticResistance #DrugDesign #InnovativeCompounds #PharmaceuticalResearch #MolecularDocking

MTT Assay: Assessing Cell Health in a Snap The MTT assay is a popular tool in cell biology for gauging cellular metabolic activity. This activity indirectly reflects the number of viable cells present, making it a handy assay for: Cell viability: See if your cells are alive and well! Cell proliferation: Monitor cell growth over time. Cytotoxicity: Test the effects of drugs or other agents on cell health. Why it's great: Fast and easy: Get results in a few hours. Quantitative: Measure cell health through a colorimetric readout. High-throughput: Analyze many samples simultaneously. #cellbiology #cytotoxicity #cellproliferation #research

Are you attending the 29th Annual Meeting #RNA2024 of the The RNA Society in Edinburgh, Scotland? Don't miss Anahi Higuera´s poster presentation titled "Time-Dependent Binding of Molecules and Influence on RNA Modification: From Proteins to RNA-Based Therapeutics." Join Anahi to explore #switchSENSE, a cutting-edge biophysical technique for characterizing #RNA-binding proteins, nucleic acid aptamers, and antisense oligonucleotides. Connect with us on-site to dive into the world of molecular interactions and #drugdiscovery! #DiscoverMolecularInteractions