Chronic Disease Day is observed annually on July 10 to raise awareness that the top 10 causes of death in the U.S. stem from chronic diseases or illnesses. Below are the top 10: 1. Obesity 2. Hypertension 3. High cholesterol 4. Coronary heart disease (CHD) 5. Chronic obstructive pulmonary disease (COPD) 6. Asthma 7. Chronic kidney disease (CKD) 8. Diabetes 9. Cancer (excluding skin cancer) 10. Depression To learn more about chronic kidney disease, visit https://lnkd.in/eCK893n
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🧬TNF (Tumor Necrosis Factor) plays a significant role in autoimmune diseases by promoting inflammation. Elevated TNF levels are often associated with increased disease activity and severity in conditions like rheumatoid arthritis, Crohn's disease, and psoriasis. 🔸 Autoimmunity and TNF - In autoimmune diseases, the immune system mistakenly attacks healthy tissues, leading to inflammation. TNF contributes to this process by stimulating immune responses and promoting tissue damage. 🔸 CRP Levels - C-Reactive Protein (CRP) is a marker of inflammation in the body. Elevated CRP levels indicate increased inflammation, often reflecting disease activity in autoimmune conditions. 🔸 The Relationship - Higher TNF levels can lead to increased CRP production, reflecting the degree of inflammation and disease activity in autoimmune conditions. Monitoring both TNF and CRP levels can provide valuable insights into disease progression and response to treatment. Understanding the relationship between TNF, autoimmunity, and CRP levels can help in managing autoimmune diseases more effectively. Regular monitoring and targeted therapies can help control inflammation, improve symptoms, and enhance quality of life.💪🩺 #TNF #Autoimmunity #CRPLevels #HealthAwareness #InflammatoryMarkers #inflammation #CRP #childhoodtrauma #immunity #immunesystem
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Understanding the pivotal regulatory roles of healthy abdominal fatty tissue in signal transduction may answer the question: how can abundant visceral fat deposition lead to serious, life-threatening diseases, such as cardiovascular lesions and malignancies
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Translational Science Lead at AstraZeneca | Immunology | Cell Therapy | Oncology | Precision Medicine | Biomarker Discovery
Lupus nephritis-related chronic kidney disease - In this review, the authors summarize treatment goals in patients with SLE and kidney involvement, draw attention to all factors, both immune and non-immune, that promote the progression of CKD in patients with lupus nephritis, and discuss the dual interpretation of proteinuria in patients with SLE. - Lupus nephritis is a common complication of systemic lupus erythematosus (SLE) and a determinant of overall morbidity and mortality, as lupus nephritis-related chronic kidney disease (CKD) drives cardiovascular disease and secondary immunodeficiency. - Two lines of action are required to prevent the progression of lupus nephritis-related CKD: suppression of autoimmune SLE activity, which is a risk factor for immunopathology-related irreversible kidney injury, and management of non-immune risk factors that contribute to CKD progression. https://lnkd.in/dcnMDQBx #SLE #autoimmunity #CKD #lupus
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The role of ncRNA in immunity- Downregulation of let-7 miRNA is associated with T-Cell inflammation and COPD in this excellent paper from Erice et al. https://lnkd.in/eaGGy3wf
Downregulation of Let-7 miRNA promotes Tc17 differentiation and emphysema via de-repression of RORγt
elifesciences.org
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A seasoned leader in procurement, supply chain, and operations, skilled in streamlining supply chains and strategic negotiations. Expert in optimizing efficiencies and integrating innovative solutions for superior care.
Weekly semaglutide injections, like Ozempic, significantly reduce the risk of severe kidney events by 24%, major cardiovascular events by 18%, and overall mortality by 20% among people with type 2 diabetes and chronic kidney disease, according to a new study. This research highlights the transformative benefits of semaglutide, making it a crucial treatment option for diabetic kidney disease, though accessibility remains a challenge. #FreseniusMedicalCare #Diabetes #KidneyDisease #Semaglutide #Ozempic #MedicalResearch #HealthcareInnovation
Ozempic reduces risk of serious illness and death in people with diabetes and kidney disease, study finds
msn.com
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Nucleosome/NETs-ICs bind to heparan sulfate in the GBM of patients with active LN and can likely be removed from the blood when persistently elevated utilizing covalently immobilized heparin blood purification. "These findings suggest that nucleosome-mediated binding of autoantibodies to basement membranes may also occur at sites in the body other than in the glomerulus". Deposition of nucleosomal antigens (histones and DNA) in the epidermal basement membrane in human lupus nephritis. https://lnkd.in/ekxEhW-q Berden
Circulating NETs are being realized as useful prognostic markers for tracking Lupus Nephritis severity and response to treatment in a new study. NETs/nucleosomes are likely primary targets for improved treatment as well, not only for LN but also for end-stage renal disease due to other causes. https://lnkd.in/eCkcx9ZU
New Potential Predictive Biomarker for Lupus Nephritis
lupus.org
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With its antihyperglycemic potential, anti-inflammatory, and pleiotropic effects (lipid lowering, antiplatelet, antithrombotic) HCQ stands out as a therapeutic option that is affordable for patients with uncontrolled T2D who are at risk for complications. The pleiotropic benefits of HCQ extend beyond rheumatic diseases with potential in prediabetes, T2D and ASCVD. https://lnkd.in/dZU3UBSB
Hydroxychloroquine pleiotropic benefits: is there any evidence beyond rheumatological diseases?
msjonline.org
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*ONE HEALTH Update 275* *Insulin Resistance*- *A silent epidemic* : *Part-1* Insulin resistance occurs when cells stop responding properly to the hormone insulin. This leads to chronically elevated blood sugar and insulin levels, which wreak havoc on virtually every system in the body. Insulin resistance is a silent epidemic sweeping the globe. Over time, insulin resistance drastically raises your risk of devastating conditions like: Heart disease and stroke, Alzheimer’s and dementia, Cancer, Kidney failure, Blindness and amputations. In fact, the top five causes of death globally – heart disease, stroke, hypertension, diabetes, cancer – all share one common root: insulin resistance.Unlike cancer or infectious diseases, insulin resistance is a spectrum. It’s not a black-and-white diagnosis, but a gradual loss of insulin sensitivity. (Source Journee Mondiale)
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Professor of Medicine. Internist | Hypertensiologist | Nutritionist | Cardiovascular Risk | Digital Medicine | Biomedicine
SGLT2 i and GLP-1RA and CVD. Innovative therapies for DM and consequences beyond expectations in CVD: 👉Better control of metabolic disease, 👉Excellent results in CVD outcomes, 👉 Pluse important pleiotropic effects.
SGLT-2i and GLP-1RA Therapy Among Patients with Type 2 Diabetes by NAFLD Status
jamanetwork.com
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🔥 HOT TOPIC - New Episode Alert🔥 A recent study shared at The Liver Meeting by the American Association for the Study of Liver Diseases tells us that the most common type of long-lasting liver disease is expected to increase a lot in the next 25 years. This could make it tough for our healthcare systems, as predictions suggest there might be almost twice as many people with liver cancer and almost three times as many needing liver transplants by 2050. Why is this happening? Well, they point fingers at the growing numbers of obesity and diabetes. These health problems are linked to a non-alcoholic liver disease, now called metabolic dysfunction-associated steatotic liver disease or MASLD. This condition affects more than 30% of people globally. Learn more about these findings and how we can deal with this growing health challenge. 🎙️Listen to the full episode https://lnkd.in/gs3FsvRy 👀 Watch the episode in full https://lnkd.in/gArEJ9RK
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