David Kingsley’s Post

Whenever I lack motivation, I watch this. It's the best video you will see this year: We're currently living in one of mankind's greatest eras of technological wonder. AI, autonomous vehicles, robots, rockets, space. All pushing the boundaries beyond what once was thought to be impossible. Long humanity 🖤 P.S. for more great stuff, check out 🔔linas.substack.com🔔, it's the only newsletter you need for all things when Finance meets Technology. For founders, builders, and leaders.

Did you know that #microglia can rescue #neurons from aggregate-induced #neuronal dysfunction and death through tunneling #nanotubes? Here is a very interesting article by the lab of Michael Heneka at the Luxembourg Centre for Systems Biomedicine (LCSB) - University of Luxembourg in which the authors show how microglia establish connections with neurons using tunneling nanotubes (#TNTs), removing toxic aggregates of alpha-synuclein (α-syn) and tau from their #cytoplasm, and supplying them with healthy #mitochondria. Article in #Neuron (published July 25, 2024): https://lnkd.in/edQjHsED Interested in learning how we at the BioMed X Institute in #Heidelberg study the transfer of dysfunctional mitochondria between immune cells during #autoimmunity and #neuroinflammation? Visit the web page of #TeamTDA led by Gorjana Rackov in collaboration with Merck Gruppe: https://lnkd.in/eBUaYzYX #immunology #neuroscience #neurodegeneration #amyloidosis #parkinson #alzheimer #multiplesclerosis

Our big news today! Our first Phase IIa just read out and we are analyzing the unblinded data, so this is preliminary and we plan to publish in a peer-reviewed journal and present at industry conference. Having said that and with all the disclaimers, the primary and secondary endpoints were met. And while the number of patients is small to make big claim, we see dose-dependent improvements in Force Vital Capacity (FVC). When I first saw the unblinded data on the internal call I dropped a few tears - it was the happiest moment in my life. I previously liked the feeling of seeing a big experimental paper published. Now, I am addicted to this new feeling of seeing a positive clinical safety and efficacy readout - nothing is more pleasant and all I want to do now is to live this moment again. It took us a while to launch the software that many of my readers here use for drug discovery and constantly improve with your feedback and requests for new models. And in 2022, we set an internal record nominating 9 preclinical candidates (PCCs) in a single year (some of these now licensed out) and started our first Phase I which concluded in 2023 (later published in Nature Biotechnology). So now, in September 2024, seeing the Phase IIa readout with good safety and dose-dependent FVC response after just 12 weeks of dosing is incredible feeling. And it would not have been possible without a deeply committed team. It is our 14th year together with our brilliant AI guru Alex Aliper and 4th year with Dr. Feng Ren who made it all happen. Congrats to Sujata Rao , our Chief Medical Officer and to the drug discovery and AI teams who worked tirelessly over the years to make it happen. Thanks to everyone who believed in us when we did not have any preclinical candidates, software, or even revenue. And thanks to everyone who was critical, skeptical, and adversarial - I will remember you as motivators. #AI #DrugDiscovery #PhaseII #TNIK #Insilico #GenAI

I have never seen anything like this before. The shell of this embryos disintegrates on day 2, the embryo forms a blastocyst. When I tried to handle this embryo completely disintegrated also. As always I believe that sharing these anomalies is the most important thing we can do. As the more we share, the more patients we can help, especially if we have seen it before. I don’t think we could have done anything any different here. But would love to hear if anyone else has ever come across this. Two of this patients eggs/embryos did the same thing. The other embryo failed to grow but this one carried on. Pretty amazing to watch for sure! 😳