💲 Ratio Therapeutics On BMS Investment, Radiopharma R&D Trends, AI Use ⭐ Who should hear this? BD and competitive intelligence execs at pharma and biotech companies with oncology portfolios/pipelines. VC investors. ⭐What is it? A podcast interview with the CEO and CSO of a Boston-based company with two radiopharmaceutical R&D platforms, and BMS as an investor. This interview digs into the company’s science, the use of AI, trends in research including combining radiopharmaceuticals with other anticancer modalities and partnering. ⭐Why is it important? Radiopharmaceuticals is a hot area in pharma, and significant deals are being done in the space (including AstraZeneca’s $2bn purchase of Fusion Pharmaceuticals [free to read, with a chart of recent big deals]). These valuable insights will be of interest to big pharma and investors looking to expand in the space, and rival companies wanting competitive intelligence. Citeline Citeline Commercial
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Stories making headlines today in the biopharma industry: Biotech companies, focusing on radiopharmaceuticals, neuroscience, and inflammation therapies, are being acquired for substantial premiums due to their potential to bridge gaps in the pharmaceutical field. For instance, Bristol Myers Squibb purchased radiopharmaceutical company RayzeBio at a 104% premium just three months post-IPO. Raising the bar in the oncology biotech space, Pennsylvania-based ArriVent BioPharma prepares for a $175 million IPO on Nasdaq with its furmonertinib, an EGFR-targeted tyrosine kinase inhibitor, being its lead asset. Venture capital player Innovation Endeavors, co-founded by ex-Google CEO Eric Schmidt, has launched a new $630 million fund. A significant portion of this fund will invest in life sciences and healthcare, indicating the firm's increasing focus on biotech. Merck's cancer prevention drug, Keytruda, demonstrates a 31% reduction in the risk of bladder cancer recurrence or death post-surgery. Despite not achieving its expected survival endpoint, the interim analysis data shows promise. In other news, Deerfield exits a 2017 deal with Windtree Therapeutics, while Travere Therapeutics finalizes a new $120 million deal with Renalys Pharma. Additionally, Celularity raised $21 million, and Sagimet Biosciences plans for a $112.5 million public offering. Moving towards pipeline development, Strand Therapeutics scales back its workforce by 18%. However, stay optimistic as CEO Jacob Becraft assures the firm’s robust financial runway. Navigating through challenges in 2023, Lonza remains hopeful about revenue growth this year along with plans to shutter its second biologics site soon. Personal updates reveal Bayer's radiology head planning retirement and ex-Sanofi chief Olivier Brandicourt joining BeiGene’s board. After facing a dip in VC and financing in 2023, the UK's life sciences sector now seems primed for an upward trajectory. #pharma #biotech #topstories #biodatastudio
"Biotech Bidding Wars, IPOs, and Advancements Ignite Excitement in the Life Sciences Sector"
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Major Partnerships in AI-focused biotech 🔬 Absci and AstraZeneca: A $247 million deal was announced in December 2023 to develop AI-designed anticancer antibodies. 🔬 BigHat Biosciences and AbbVie: A collaboration worth over $200 million to leverage AI for antibody development. 🔬 BigHat Biosciences and Almirall: A $610 million deal to create AI-designed therapeutics for dermatological diseases. 🔬 Sanofi and BioMap: A partnership potentially worth more than $1 billion to develop AI models for biological design. 🔬 Xaira Therapeutics, Co-founded by David Baker, is an AI-focused biotech that launched with over $1 billion in funding. It aims to use generative AI tools like diffusion models to design next-generation biologics. 🤝 These partnerships and innovations are not just significant; they are game-changers. They underscore the growing impact of AI in biotech, paving the way for faster and more efficient development of therapeutic antibodies. The integration of AI and biologics expertise is poised to revolutionize the industry, offering new hope for the treatment of various diseases. #artificalintelligence
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https://lnkd.in/evKTiDAK City Therapeutics, a Cambridge, MA-based biopharmaceutical company which specializes in RNA interference (RNAi)-based medicine, raised $135M in Series A funding. The round was led by ARCH Venture Partners with participation from Fidelity Management & Research Company, Invus, Slate Path Capital, Rock Springs Capital, Regeneron Ventures, AN Ventures and others undisclosed investors. The company intends to use the funds to advance innovations in siRNA design, delivery and targeting that enable improved potency and specificity, broader access across more tissue types, and expanded opportunities in multiple therapeutic areas. City Therapeutics is a biotechnology company that provides an siRNA-engineering platform aimed at designing, improving and optimizing RNAi-based medicines. Platform pillars include: The design of novel RNAi triggers, including those with smaller size, novel cellular mechanisms and improved potency, efficiency and specificity. Examples include cleavage-inducing tiny (city) RNAs that induce target mRNA cleavage through distinct proteins to silence gene expression. Targeting ligands for specific and enhanced delivery of engineered siRNAs to a broader range of cells and tissue types. Leveraging advancements and insights in human genetics to address both novel and validated therapeutic targets and optimize clinical development. City Therapeutics is building a pipeline of innovative RNAi therapeutics, with its lead program expected to enter clinical development at or around the end of 2025. Thereafter, the company’s product engine is aimed at delivering a sustainable flow of high impact RNAi-based medicines, with one to two new Investigational New Drug applications (INDs) per year starting in 2026.
City Therapeutics Raises $135M in Series A Financing
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Stories making headlines today in the biopharma industry: BeiGene, the Chinese biotech company, has drawn curtains on its partnership with Shoreline Biosciences which was positioned as BeiGene's step into cell therapy. The collaboration was prematurely terminated, despite a $45 million upfront payment by BeiGene at the outset in January 2022. The partnership was burgeoning to develop cell therapies across four therapeutic targets, with BeiGene tasked with holding worldwide commercial rights. The untimely termination came after a strategic portfolio review, fueled majorly by BeiGene's internal prioritization decisions and not due to flaws in Shoreline’s platform technology. Elsewhere, Gilead Sciences was the sole bidder for liver disease biotech CymaBay Therapeutics, as revealed in recent securities filings. Its initial proposal was amplified by $9.50 per share, eventually settling on a final offer of $32.50 per share, marking a 27% premium to the prior day's closing price. The transaction, worth a mammoth $4.3 billion, underscores a prevailing trend for big Pharma companies to scoop up late-stage deals to consolidate their drug pipelines. Meanwhile, NGM Bio is set to transition to a private company after more than a decade and a half in operation. NGM Bio's largest shareholder, biotech investor The Column Group, is putting plans in motion to privatize the company in a deal estimated at $135.0 million, following a complex R&D journey in NASH, retinal diseases and other areas. In terms of workforce reduction, Thermo Fisher reported a contraction of 8,000 roles, representing about 6% of its workforce in 2023, with the Americas region witnessing the majority of the change. The company noted a 5% dip in its 2023 revenue to $42.86 billion, down from $44.9 billion in the previous year. Finally, Celldex Therapeutics' anti-KIT antibody fulfilled the primary objective in a mid-stage test for chronic spontaneous urticaria, according to initial results. Analysts are optimistic that Celldex's therapy will pose significant competition to a similar but more advanced therapy by Novartis, particularly given there are currently no approved treatments for patients who do not respond to Xolair, a drug manufactured jointly by Novartis and Genentech. #pharma #biotech #topstories #biodatastudio
Biotech Breakdown: BeiGene ends pact, Gilead's bid, NGM Bio goes private, Thermo Fisher downsized
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Isomorphic Labs, a London-based AI drug discovery startup, has partnered with Eli Lilly & Co. and Novartis AG, two of the world's largest pharmaceutical companies, in deals valued at nearly $3 billion. Isomorphic Labs will utilize AlphaFold, an AI system developed by DeepMind, to predict protein structures and focus on small molecule therapeutics. The partnerships with Eli Lilly and Novartis provide Isomorphic Labs with significant financial resources, industry expertise, and market validation, accelerating their efforts in developing innovative drugs and bringing them to patients faster. Takeaway: The collaboration between Isomorphic Labs, Eli Lilly, and Novartis signifies a powerful combination of AI-driven drug discovery, financial backing, and industry expertise, which will accelerate the development of life-saving small molecule therapeutics. #AI #DrugDiscovery #Pharmaceuticals #ArtificialIntelligence #DeepLearning #AlphaFold #IsomorphicLabs #EliLilly #Novartis #Innovation
Isomorphic Labs, a London-based AI drug discovery startup, has partnered with Eli Lilly & Co. and Novartis AG, two of the world's largest pharmaceutical companies, in deals valued at nearly $3 billion. Isomorphic Labs will utilize AlphaFold, an AI system developed by DeepMind, to predict protein structures and focus on small molecule therapeutics. The partnerships with Eli Lilly and Novartis ...
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Stories making headlines today in the biopharma industry: #PharmaUpdate: A record-breaking $153B has been funneled into R&D by pharmaceutical entities. This push is driven largely by a rising trend in mergers and acquisitions, indicating a strategic response to patent expirations or as a remedy to pipeline gaps. Roche has its sights set on Alzheimer’s disease with early data from a Phase Ib/IIa study revealing encouraging results for high-dose trontinemab, an amyloid-targeting antibody. If these preliminary results continue to offer promise, we could potentially see Roche making strides in developing an Alzheimer’s treatment. In a potentially billion-dollar partnership, Merck is teaming up with Pearl Bio to develop innovative cancer biologics. While Pearl Bio is still in its infancy, such collaboration may pave the way for launching approved drugs in the future. Despite Bristol Myers Squibb leaving one more CytomX program in the lurch amidst a ten-year research collaboration, CytomX remains undeterred and continues to progress with its preclinical programs. Securing $100 million following promising Phase I trial data, Regulus Therapeutics joins Skye Bioscience in successful fundraising efforts. Making its own statement is Lirum Therapeutics, filing for a $25 million IPO and setting sights on Phase I testing for its lead program in Ewing sarcoma and other cancers. Meanwhile, in the wake of its Phase III trial disappointment in schizophrenia, Acadia Pharmaceuticals announced that it will cease further clinical trials with Nuplazid (pimavanserin), though data analysis will continue. The failure was ascribed to an unexpectedly robust placebo performance. #PharmaNews #PharmaceuticalIndustry #HealthcareInnovation #pharma #biotech #topstories #biodatastudio
Pharma Giants Spend Big on R&D and M&A Deals: Industry Sees Record $153B Investment
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👩🏼🔬Cellply, #portfolio #IAG, a leading developer of analytical tools for research and quality control within the “Cell Therapy” sector, announced the launch of its flagship product VivaCyte.® a tool capable of reducing development times, costs, and risks – is the first fully integrated platform of its kind to characterize the complex functionality and mechanism of action of potential cellular immunotherapies rapidly and comprehensively. Emiliano Spagnolo: “Helping the #biopharmaceutical industry to identify and develop the most effective versions of their cellular therapies is our goal". Read more👇 #lifescience #innovation Massimo Bocchi Antonio Leone
Cellply launches its end-to-end single cell potency characterization platform VivaCyte | CELLPLY
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Scope 1,2,3 GHG reduction, SBTi, CDP, Ecovadis, Climate Change, Net Zero, Sustainability & ESG Practice
This new blog post explains how to enhance precision in target and lead selection for biologics, focusing on employing a combination of patient-derived models, functional assays, and biomarker discovery tools. By adopting these technologies, researchers are better equipped to tackle the challenges of biologic development, potentially leading to more effective and personalized therapeutic options for patients.
How to Enhance Precision in Target and Lead Selection for Biologics
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CEO and Founder CellTherEx Consulting AB and CSO NextCell Pharma AB | ISCT European Regional Secretary
Great to speak with Pharma's Almanac and share my thoughts on current investment trends. Read more below! #investment #biotech #pharma #cgt #cellandgenetherapy #celltherapy #atmps #future #vision #thoughts #development NextCell Pharma AB
In this new Pharma's Almanac roundtable, a panel of industry experts weighs in on the most impactful investment trends influencing pharma and biopharma. This roundtable features contributors from: Alconox Inc., TriRx Pharmaceutical Services, LLC, Sonata Therapeutics, Flagship Pioneering, GBI Biomanufacturing, Fab Biopharma, Quotient Sciences, Mikart, LLC, Oxford Biomedica, PCI Pharma Services, Samsung Biologics, Simtra BioPharma Solutions, Cambrex, Astrea Bioseparations, N4 Pharma Plc, Lonza, SK pharmteco, Center for Breakthrough Medicines, Epocrates Inc, Thermo Fisher Scientific, OM1, Inc., Bruker BioSpin, MilliporeSigma, Certara, Seer, eClinical Solutions, Spinogenix, Inc., ProPharma, ScaleReady, REITHERA, eXmoor Pharma, NextCell Pharma AB, OrganoBiotech, Inc., and Catalent Pharma Solutions
What are the Current Investment Trends in the Pharmaceutical Industry, and How are They Influencing the Sector’s Direction?
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This new blog post explains how to enhance precision in target and lead selection for biologics, focusing on employing a combination of patient-derived models, functional assays, and biomarker discovery tools. By adopting these technologies, researchers are better equipped to tackle the challenges of biologic development, potentially leading to more effective and personalized therapeutic options for patients.
How to Enhance Precision in Target and Lead Selection for Biologics
blog.crownbio.com
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