We are proud to sponsor Gordon Research Conferences Intrinsically Disordered Proteins 2024! 🙌
Intrinsically disordered proteins (IDPs), as opposed to intrinsically foldable proteins, do not adopt unique folded structures but instead exist as ensembles of dynamic and unstructured interconverting conformations. IDPs and ID regions function through these conformational ensembles and are drivers of biological outputs. The conformations of IDPs are a direct consequence of their sequences, physicochemical properties, and the environment in which they reside. IDPs come in many different flavours, exemplified by sequence features such as amino acid composition and patterning, and they can exist in the context of multi-domain proteins and in different environmental contexts. Combined, this determines their functions and mechanisms of action in different cells and organisms. Sequences can also encode material properties that emerge when many molecules come together in large assemblies, and this is important in biological function as well as for biomaterial science. Understanding how the sequence grammar and the precise context give rise to conformations and functions, from single molecules to assemblies, on time scales from picoseconds to years, is important for elucidating how IDPs shape biology and how their dysregulation gives rise to diseases.
GRC's vision for this meeting is to bring scientists at all levels and from many fields together to tackle interdisciplinary questions on IDPs in biological function and disease-related dysfunction. Sessions will prioritize emerging research focusing on the quantitative elucidation of fundamental principles and mechanisms using biophysical, biochemical, cell biological, computational, and theoretical approaches, showcasing biological functions of IDPs across the cellular landscape.
Don't miss out on this informative meeting! 😱
Learn more: https://lnkd.in/ez_mcz7j
#IDP #Biophysics #GRC #AppliedPhotophysics