Delix Therapeutics’ Post

Exciting announcement this morning! We are thrilled to announce PUR501 as our lead candidate for a novel non-hallucinogenic neuroplastogen! PUR501, an orally bioavailable serotonin 2A (5-HT2A) receptor partial agonist, has shown promising results in promoting neuroplasticity without inducing hallucinations. Key Highlights: 🔹 Positive effects on structural neuroplasticity 🔹 Minimal hallucinogenic capacity 🔹 Safe cardiac profile Our CEO and co-founder, Janet Qi, shared, "Selecting PUR501 as our lead development candidate marks a significant milestone. We are excited to commence IND-enabling activities in late 2024, aiming to establish a new treatment paradigm for neurocognitive impairment." Stay tuned for more updates as we complete preclinical development and prepare for IND submission! Check out the full press release! Link in bio. #PurMindsNeuroPharma #Neuroplasticity #InnovativeTherapies #Neuroscience #NeurodegenerativeDiseases #PharmaceuticalResearch

Neuroscience: Advances in research and opportunities ahead The global prevalence of dementia is approximately 24 million, and is predicted to double every 20 years until at least 2040. Currently, no medications can cure this, though 2024 has proved to be a poignant year of developments in neuroscience, especially considering the challenges faced in previous decades. This guide showcases the potential within drug discovery. Download this In Focus eReport to learn more about the drug discovery innovation and advancement taking place in this field. The eReport includes: - A global market overview including prevalence, value and future outlook - A scientific article on developing therapeutics targeting biomolecular condensates - An interview with ApconiX’s Director and Co-founder, Professor Ruth Roberts, and Scientific Lead, Kimberly Rockley - An exploration of the new frontiers in neuroscience Download the e-report https://lnkd.in/eCEEdBCu Sponsored by ApconiX #Neuroscience #Therapeutics #DrugDiscovery

We are excited to announce a research collaboration with Tessara Therapeutics, renowned for their expertise in creating #humanBrainOrganoids. Together, we develop complex cellular models of co-cultured human neurons and glial cells in microplate formats for image-based analysis using High Content Screening microscopy (Opera Phenix by Revvity). Our collaboration exemplifies the power of combining cutting-edge imaging technology with advanced organoid models to push the boundaries of neuroscience research. 🎥 Check out our latest movie, showcasing a 3D reconstruction of a brain organoid in a miniaturized format. The first seconds provide a maximum projection overview, followed by a detailed representation of the volumetric structure of part of the organoid (left) and a magnified region with higher resolution (right). The green color highlights the β-III tubulin staining for neurites, while the red color indicates the signal from glial cells. This cell culture system can be utilized to test the effects of drugs on human neuronal disease models, providing critical insights into neurogenesis and neuroplasticity within a organ-like context. The use of organoid systems will allow to pharmacologically interrogate yet unprecedented biology. Stay tuned for more updates on our research and the future of drug discovery! #Axxam #TessaraTherapeutics #HighContentImaging #BrainOrganoids #Neuroscience #Innovation #DrugDiscovery #RealBrain

Schema of construction and applications of human cardiac organoids. (Left) Following aggregation or directed differentiation of hPSCs, cardiac organoids are constructed by differentiation and self-organization of aggregated hPSCs (i.e., EBs), or direct assembly of hPSC-derived cardiac cells such as CMs, ECs and CFBs under the 3D environment with anti-adherent culture plates, dynamic culture (shaking), and/or biological scaffolds. (Right) The applications of cardiac organoids involve the modeling of cardiogenesis and/or heart diseases, drug screening and development with or without targeting personalized medicine, and regenerative medicine. CFB, cardiac fibroblast; CM, cardiomyocyte; EB, embryoid body; EC, endothelial cell; hPSC, human pluripotent stem cell https://lnkd.in/ehKXwUtW #Gesundheit #Bildung #Fuehrung #Coaching #Mindset #Motivation #Gehirn #Neuroscience #Psychologie #Persoenlichkeitsentwicklung #Kindheit #KeyNoteSpeaker #Humangenetik #Biochemie #Neuroleadership #Ernaehrung #Transformation #Stress #Demografie #Gender #Age #interkulturelleKompetenz #Epigenetik #Veraenderung #EmotionaleIntelligenz #Change #Gesellschaft #Organisationsentwicklung #Philosophie #Beratung # Quantum

☑️ *READ DESCRIPTION BELOW:* Overview of applications for spinal cord organoid (SCO) modeling. (A) Studying human spinal cord development by collecting SCOs at different time points allows us to perform longitudinal studies (i.e., scRNAseq analysis, lineage tracing) that can be benchmarked against in vivo counterparts. (B) Assembling multiple organoids or spheroids, fusing them into one coherent structure, allows researchers to study corticomotor circuits. Alternatively, hiPSCs can be induced into neuromesodermal progenitors (NMPs), bipotent cells that can give rise to both neuroectoderm and the cognate skeletal muscle. (C) High-throughput small-molecule screens on SCOs to identify new potential therapeutic targets. (D) SCOs or their derivatives have the potential to become sources for cell transplantation, aiming to6hb ameliorate neuronal loss or restore and regenerate function in neuromuscular diseases https://lnkd.in/eysavF-C #Gesundheit #Bildung #Fuehrung #Coaching #Mindset #Motivation #Gehirn #Neuroscience #Psychologie #Persoenlichkeitsentwicklung #Kindheit #KeyNoteSpeaker #Humangenetik #Biochemie #Neuroleadership #Ernaehrung #Transformation #Stress #Demografie #Gender #Age #interkulturelleKompetenz #Epigenetik #Veraenderung #EmotionaleIntelligenz #Change #Gesellschaft #Organisationsentwicklung #Philosophie #Beratung # Quantum

Exciting news in neuroscience diagnostics! Fujirebio Diagnostics, Inc. has launched the Lumipulse G GFAP assay in the US, a groundbreaking tool for researchers studying neurological conditions. This fully automated Chemiluminescent Enzyme Immunoassay (CLEIA) test quantitatively measures glial fibrillary acidic protein (GFAP) in human plasma and serum in just 35 minutes. Goki Ishikawa, President and CEO of Fujirebio Holdings, Inc., states: "We continue our engagement in biomarker-based testing for neurological diseases with the Lumipulse G GFAP, affirming our commitment to play an essential partnering role in both research and clinical routine." This launch further solidifies Fujirebio's position as a leader in neuro biomarker testing, following their 2023 introductions of NfL and pTau 217 assays. https://lnkd.in/euNv5Sat 📰 Stay ahead of the curve by following Practical Patient Care on LinkedIn for more industry news and insights. #PracticalPatientCare #Neuroscience #Diagnostics #MedicalInnovation

The Role of IL-2 in Multiple Sclerosis, illustrated by Mica Duran. Cellular level discussion of multiple sclerosis disease state — used as booth graphics for therapeutic monoclonal antibody Daclizumab (Zenapax®). Explore more of Mica's work on the Medical Illustration & Animation Sourcebook online site: https://buff.ly/3nwQma0 #multiplesclerosis #ms #neuroscience #virology #pharmacology #medical #illustration #medicalillustration #scientificillustration #medicalillustrator #3D #sciart #cellbiology #molecularbiolology #science

🚀𝐒𝐄𝐄𝐆 𝐈𝐧𝐬𝐢𝐠𝐡𝐭: 𝐌𝐚𝐩𝐩𝐢𝐧𝐠 𝐁𝐫𝐚𝐢𝐧 𝐀𝐜𝐭𝐢𝐯𝐢𝐭𝐲 𝐰𝐢𝐭𝐡 𝐏𝐫𝐞𝐜𝐢𝐬𝐢𝐨𝐧 𝐃𝐞𝐩𝐭𝐡 𝐄𝐥𝐞𝐜𝐭𝐫𝐨𝐝𝐞𝐬🚀 SEEG electrodes can be localized better, resulting in surgical resection and a good seizure outcome. 📈𝐑𝐢𝐬𝐢𝐧𝐠 𝐧𝐮𝐦𝐛𝐞𝐫 𝐨𝐟 𝐩𝐚𝐭𝐢𝐞𝐧𝐭𝐬 𝐬𝐮𝐟𝐟𝐞𝐫𝐢𝐧𝐠 𝐟𝐫𝐨𝐦 𝐜𝐡𝐫𝐨𝐧𝐢𝐜 𝐧𝐞𝐮𝐫𝐨𝐥𝐨𝐠𝐢𝐜𝐚𝐥 𝐝𝐢𝐬𝐨𝐫𝐝𝐞𝐫𝐬 The SEEG Depth Electrode market has grown with the factors considering such as the rising occurrence of chronic and neurological diseases, increasing investment in the advanced technologies by leading biopharmaceutical companies with the singular focus to increase the efficacy rate with minimal surgical procedures. ▶ ⭐ 𝑫𝒐𝒘𝒏𝒍𝒐𝒂𝒅 𝒕𝒉𝒆 𝑺𝒂𝒎𝒑𝒍𝒆 𝑹𝒆𝒑𝒐𝒓𝒕:  https://lnkd.in/dhQ-Znwq The SEEG depth electrodes market in the Europe region is anticipated to grow at a positive growth rate in the analysis period. Global SEEG Depth Electrodes Market was valued at USD 20.6 Million in 2021 and is expected to reach USD 29.5 Million by the year 2028, at a CAGR of 6.18%. 👇𝐒𝐨𝐦𝐞 𝐨𝐟 𝐭𝐡𝐞 𝐤𝐞𝐲 𝐩𝐥𝐚𝐲𝐞𝐫𝐬 𝐢𝐧 𝐒𝐄𝐄𝐆 𝐃𝐞𝐩𝐭𝐡 𝐄𝐥𝐞𝐜𝐭𝐫𝐨𝐝𝐞𝐬 𝐌𝐚𝐫𝐤𝐞𝐭 𝐢𝐧𝐜𝐥𝐮𝐝𝐞: Ad-Tech Medical Instrument Corporation (US) DIXI Medical (France) PMT Corporation (US) NeuroOne (US) Integra LifeSciences (US) Natus Medical Incorporated (US) NeuroPace Inc. (US) and other major players. #seegdepth #neuroscience #electrophysiology #brainmapping #neurosurgery #medicaldevices #neurotechnology #epilepsyawareness #brainhealth #seizecontrol #usa #russia

Advance your drug development with MD Biosciences Neuro! As a partner with expertise in #pain, #neurodegeneration and #neuroinflammation, we are dedicated to providing each client with valued expertise, advice, and flexibility to meet the needs of rapidly changing requirements. Learn more about how we can work together: https://hubs.la/Q02v3Zhs0 #drugdevelopment #translationalresearch #painresearch #neuroscience #preclinicalCRO #preclinicalresearch

Thanks to our partnership with the Bordeaux University Hospital Neurosurgery department, we have access to human brain tissue samples resulting from surgeries in epileptic patients. Over the years, we've developed expertise in performing regular in vitro electrophysiology recordings and analyses in human brain slices.   🧠 Understanding how compounds or molecules interact with the human brain at the neuronal level is crucial for advancing neuroscience research and drug development. Human Brain Slice studies offer direct insights into human physiology and pathology, complementing rodent models and paving the way for more translational discoveries.   Curious to learn more? Click the link below to dive into our article uncovering the value of studying compounds on human brain slices! #Neuroscience #BrainResearch #HumanBrainSlices