🧫 As the threat of antibiotic resistance looms, scientists are designing new drugs to fight off bacteria. A team of microbiologists developed a potent inhibitor against E. coli and other Gram-negative bacteria. 💊 X-ray crystallography experiments on the I04-1 beamline unveiled how the drug latches onto an enzyme needed for the synthesis of a fatty sugar on the outer-membranes of these bacteria, presenting a new drug-enzyme interaction with therapeutic potential. Find out more in the science highlight below. ⬇ https://lnkd.in/e7VH6B9A
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In targeted protein degradation (TPD), proteins like Cereblon, CK1a and SALL4 are crucial but challenging targets. SAR studies are key for enhancing selectivity and safety, leading to better therapies. Our no-wash assays are here to support your research. Learn more http://ms.spr.ly/6040WYTI2
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A new study by Stefan Knapp and Matthias Gehringer identified 18 kinases with 19 cysteine sites, targeted for the first time! Protein kinases are important drug targets, yet only a fraction of the more than 500 human kinases have selective inhibitors. The researchers tackled this challenge by developing a library of small molecules that can attach to kinases. They systematically tested this library on 47 kinases with 60 cysteine sites near the ATP-binding pocket. Using intact protein mass spectrometry and thermal shift assays, the team located previously untargetable cysteines, discovered unique ways the molecules bind and identified specific hits that provide a solid starting point for making new and more effective covalent inhibitors. Read the full study: https://lnkd.in/dytyCX34 #OpenScience #DrugDiscovery #ProteinKinase #CovalentInhibitors
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🌿 Breakthrough in Antibiotic Resistance! 🌿 A recent computational study has unveiled promising natural compounds that could inhibit a crucial enzyme linked to antibiotic resistance in Salmonella Typhimurium. This discovery is a significant step towards addressing the global health crisis posed by fluoroquinolone-resistant infections. 🔍 Key Highlights: - Advanced computational methods modeled the DNA gyrase A protein, leading to the creation of a clinically relevant triple mutant variant. - Several natural compounds from the ChemDiv database demonstrated strong binding affinities, showcasing their potential as effective treatments. - Molecular docking studies confirmed stable interactions with both wild-type and mutant enzymes. These findings pave the way for innovative antimicrobial agents that could revolutionize our approach to combating resistant Salmonella strains. As we continue to face antibiotic resistance challenges, this research underscores the importance of integrating computational and experimental methods for developing new therapeutic options. 👉 Click on the link for more insights into this groundbreaking study! #AntibioticResistance #HealthcareInnovation #NaturalCompounds #Pharma #RegulatoryAgencies #ResearchBreakthrough #Salmonella #MarketAccess #MarketAccessToday
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Target proteins with precision and minimize off-target effects! Our latest article explores how partial PROTACs and ligand-linker conjugates are reshaping protein degradation research, opening new pathways for therapeutic breakthroughs. #drugdiscovery Find your target! https://lnkd.in/eGx3jTt4
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Target proteins with precision and minimize off-target effects! Our latest article explores how partial PROTACs and ligand-linker conjugates are reshaping protein degradation research, opening new pathways for therapeutic breakthroughs. #drugdiscovery Find your target! https://lnkd.in/dAXb2n7X
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Target proteins with precision and minimize off-target effects! Our latest article explores how partial PROTACs and ligand-linker conjugates are reshaping protein degradation research, opening new pathways for therapeutic breakthroughs. #drugdiscovery Find your target! bit.ly/4fXC8Ih
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Discover New Insights on Recombinant Proteins from Diaclone, part of Medix Biochemica 🌟🔬 We have published a new article from Diaclone that delves into the recombinant protein technology. This is a great opportunity to enhance your understanding of this vital area in research and diagnostics! 📄 Read here: https://hubs.la/Q02YSD6b0 #RecombinantProteins #Diaclone #NordicBiosite
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Target proteins with precision and minimize off-target effects! Our latest article explores how partial PROTACs and ligand-linker conjugates are reshaping protein degradation research, opening new pathways for therapeutic breakthroughs. #drugdiscovery Find your target! https://lnkd.in/g4Uh4xVJ
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Target proteins with precision and minimize off-target effects! Our latest article explores how partial PROTACs and ligand-linker conjugates are reshaping protein degradation research, opening new pathways for therapeutic breakthroughs. #drugdiscovery Find your target! https://lnkd.in/gx49QZjT
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MilliporeSigma Academic/Biotech Account Manager @ Columbia University & The Rockefeller University | Driving Scientific Solutions
Target proteins with precision and minimize off-target effects! Our latest article explores how partial PROTACs and ligand-linker conjugates are reshaping protein degradation research, opening new pathways for therapeutic breakthroughs. #drugdiscovery #Innovation Find your target! bit.ly/42zfAJO
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scientific editor (bio-med), research academia projects, part time- self employed 2018-2020 affiliated as visiting Assist Prof at BAS/Inst of Neurobiolgy
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