Are you caught up with the evolving needs of new drug modalities? 🔬 Check out our article where we go into each topic our 3 speakers and roundtable of experts discussed at this year's Meetup event. Read and watch there videos about how this topic is evolving and the opportunities it brings to the industry. ✔️Learn more: https://bit.ly/3tOx2ea #meetup #discngine #3decision #drugdiscovery
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Congratulations to this year's Nobel Prize winners in Chemistry for their groundbreaking work on protein science! 👏👏👏 Their discoveries, from computationally designing proteins 𝘥𝘦 𝘯𝘰𝘷𝘰 to using AI to predict the structures of all known proteins, are creating tremendous opportunities across chemistry, biology, medicine, and beyond. At Discngine, we’re excited to support scientists in these revolutionary efforts. Our technology helps researchers release the full potential of their protein data, turning vast structural information into valuable knowledge to rationalize and accelerate drug design and discovery. #scientific #breakthrough #discngine #3decision #drugdiscovery
BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2024 Nobel Prize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.” The Nobel Prize in Chemistry 2024 is about proteins, life’s ingenious chemical tools. David Baker has succeeded with the almost impossible feat of building entirely new kinds of proteins. Demis Hassabis and John Jumper have developed an AI model to solve a 50-year-old problem: predicting proteins’ complex structures. These discoveries hold enormous potential. The diversity of life testifies to proteins’ amazing capacity as chemical tools. They control and drive all the chemical reactions that together are the basis of life. Proteins also function as hormones, signal substances, antibodies and the building blocks of different tissues. Proteins generally consist of 20 different amino acids, which can be described as life’s building blocks. In 2003, David Baker succeeded in using these blocks to design a new protein that was unlike any other protein. Since then, his research group has produced one imaginative protein creation after another, including proteins that can be used as pharmaceuticals, vaccines, nanomaterials and tiny sensors. The second discovery concerns the prediction of protein structures. In proteins, amino acids are linked together in long strings that fold up to make a three-dimensional structure, which is decisive for the protein’s function. Since the 1970s, researchers had tried to predict protein structures from amino acid sequences, but this was notoriously difficult. However, four years ago, there was a stunning breakthrough. In 2020, Demis Hassabis and John Jumper presented an AI model called AlphaFold2. With its help, they have been able to predict the structure of virtually all the 200 million proteins that researchers have identified. Since their breakthrough, AlphaFold2 has been used by more than two million people from 190 countries. Among a myriad of scientific applications, researchers can now better understand antibiotic resistance and create images of enzymes that can decompose plastic. Life could not exist without proteins. That we can now predict protein structures and design our own proteins confers the greatest benefit to humankind. Learn more Press release: https://bit.ly/3TM8oVs Popular information: https://bit.ly/3XYHZGp Advanced information: https://bit.ly/4ewMBta
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𝙏𝙝𝙖𝙣𝙠 𝙮𝙤𝙪 𝙛𝙤𝙧 𝙟𝙤𝙞𝙣𝙞𝙣𝙜 𝙪𝙨! 🎉 A huge thank you to everyone who attended our Discngine Meetup yesterday! 🙌 It was a great opportunity to connect with over 100 participants including our customers, partners, and drug discovery experts. We managed to learn, exchange and get fresh ideas on strategies for early biotherapeutic developability assessment for novel biotherapeutics. Recap: ✔️Insightful plenary session with Norbert Furtmann about NANOBODY platform at Sanofi ✔️Product launch of 3dpredict with Discngine experts ✔️Very dynamic and diverse panel discussion led by Per Jr. Greisen, BioMap and with panelists Matthew Raybould, University of Oxford , Essam Metwally, Merck and Nels Thorsteinson Chemical Computing Group. 👏Special thanks to our speakers and participants for making this such an engaging experience. Stay tuned for event highlights and recordings! 🚀 #discngine #meetup #antibody #biologics #discovery #event
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📢Last chance to join Discngine Meetup Vol.4 Join over 200 registered drug discovery experts to discuss the strategies for the developability assessment of novel biotherapeutics this upcoming Tuesday. 🗓️ October 8th 2024 🕔4pm CET / 10am EDT / 7am PDT 📌virtual event, free of charge Check the agenda and register now: https://bit.ly/3YacA4e #discngine #meetup #event #bioloogics #discovery
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𝑷𝒓𝒐𝒕𝒆𝒊𝒏 𝒐𝒇 𝒕𝒉𝒆 𝒎𝒐𝒏𝒕𝒉 🔬 Scientists have revealed the first #CryoEM structure of the NMDA receptor bound to patient-derived monoclonal antibodies #mAbs linked to autoimmune encephalitis. These structural insights bring us a step closer to targeted treatments of neurological disorders and memory deficits in patients. ➡ Discover more in our Protein of the Month edition: https://lnkd.in/eUEPa-vU Elisa Martino Neuroscience News #discngine #3decision #pom #nmdar #antibodydiscovery
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How accurate are AlphaFold3 models? 🔬 We have been exploring the potential of #AF3 for predicting protein-protein interactions #PPIs in our case study on Programmed-cell death 1 #PD1. See what we found: https://bit.ly/46HSe4I Part 2 is coming soon, so stay tuned! 💡 #alphafold3 #prediction #proteinproteininteraction #ppi #drugdiscovery
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Discngine is back! 😎 Last week, we have spent great time at our annual offsite on the beautiful west coast of France! We balanced insightful workshops 🤓, fun activities 🏄♀️ and plenty of networking 💬. The Discngine offsite is a highly anticipated event where we come to learn new things, share knowledge and ideas across teams, meet in person and most importantly, enjoy moments together. 🚀 We are grateful for this opportunity and fully recharged to apply acquired knowledge in everyday work and efficiently face new challenges. To learn more about Discngine and opportunities to join our team, visit https://bit.ly/3MNK9m3 #discngine #offsite #20years #teambuilding #teamevent
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Discngine Meetup agenda is now live! 💡 Join experts from pharma industry to discover their experience in developability assessments of biologics, including strategies, limitations, and best practices. Moreover, this event has a highly highly networking character, where you will have the opportunity to meet peers and build relationships. 🔗See full agenda and register here: https://bit.ly/3Z8APk1 #discngine #meetup #biologics #antibody #discovery #developability
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Registrations extended 📢 We are excited to extend the registration to our event for 2 more weeks! Join us to get insights on how to achieve #FAIRness in all those data you generate in screening labs. Join us: https://lnkd.in/gEFVi-w2 #discngine #assay #samplemanagement #drugdiscovery
🌟 Enhance Sample Management with FAIR Principles in Your Research Lab Join us for the upcoming Discngine Labs, where we’ll show you how to embrace digital technology and ensure FAIR implementation with Discngine Sample! Our Product Manager, Thomas Blarre, will guide you through the main features of the solution, demonstrating how to streamline sample management and achieve FAIR data to accelerate drug discovery. 📅 Date: September 24th 🕓 Time: 4 PM CET 👉 Registrar here: https://lnkd.in/gEFVi-w2 #discngine #sample #management #drugdiscovery #FAIR #data
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A new 3decision release is out! 🎉 Our structural repository is now compatible with PDBx/mmCIF and ModelCIF file formats, providing you with even more valuable structural insights. Check it out in detail: https://bit.ly/3X6ykMk #3decision #discngine #mmCIF #sbdd #drugdiscovery
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Next Week: Don’t miss our interactive Discngine Labs event on Sample Management! 📢 Join us to discover how Discngine Assay efficiently manages large volumes of sample data in research labs, ensuring high quality and adherence to FAIR principles. 📅 Date: September 10, 2024 🔗 Read more and register here: https://bit.ly/4cPGWNa #discngine #samplemanagement #fairdata #screening #drugdesign
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