Discovery | Charles River’s Post

We're delighted to announce Pelago Bioscience AB as our Partnering Sponsor for the 2024 Medicinal Chemistry Strategy Meeting on May 15 in Princeton! Pelago Bioscience is a Discovery Research Partner specializing in biologically relevant systems, leveraging the patented CETSA® technology to drive drug discovery projects. The Cellular Thermal Shift Assay (CETSA®) offers multiple assay formats that serve as a cornerstone in decision-making throughout the drug discovery pipeline. Its unique approach enables the assessment and quantification of target engagement under physiological conditions, without modifying the compound or protein. This provides actionable and biologically relevant data, akin to snapshots of true target engagement inside the cell. With CETSA® data and applications, customers make better and more informed decisions at earlier project stages. Join us for a day of innovative discussions and breakthroughs at the 2024 Medicinal Chemistry Strategy Meeting. Register now:https://lnkd.in/grQ3cU7m #MedicinalChemistry #StrategyMeeting #MedChem #DrugDiscovery #Princeton #EastCoast #Proventa #R&D #Innovation #Collaboration #HitID #LeadOptimization #TargetEngagement #Selectivity #AI #ML #EmergingTherapies #TargetedTherapy #Collaboration

Check out our blog post for a quick summary of this recent publication in Nature Reviews Drug Discovery. #openscience to accelerate #precisionmedicine ! https://lnkd.in/e6YcSN_G

𝗢𝗻𝗹𝗶𝗻𝗲 𝗪𝗼𝗿𝗸𝘀𝗵𝗼𝗽!! Join us for an enlightening online workshop on 𝙈𝙤𝙡𝙚𝙘𝙪𝙡𝙖𝙧 𝘿𝙤𝙘𝙠𝙞𝙣𝙜, a crucial technique in drug discovery. Learn how to predict molecular interactions and binding affinities, enhancing your research and development skills. Whether you're a beginner or looking to refine your skills, this workshop will provide you some valuable insights into the process of molecular docking. Don't miss this opportunity to enhance your understanding and network with professionals in the field! #MolecularDocking #Onlineworkshop #Bioinformatics #Elearning #Drugdiscovery #ResearchInnovation #Lifesciences

We've just taken a big step forward in our journey to improve scientific discovery. 🌟 Our latest instrument installation at Philochem AG is dedicated to DNA encoded library (DEL) hit validation and is now officially up and running! Our cutting-edge technology is set to redefine how researchers can approach hit validation, which means more precise data, faster results, and ultimately, more groundbreaking discoveries. But here’s where it gets even better: this isn’t just a win for lino Biotech AG — it’s a win for all of us in the scientific community. 🧬 Whether you’re working in drug discovery, biochemistry, or any related field, the advancements we’re making here could have a ripple effect across the industry. Let's spark a conversation! Drop a comment below and let’s connect over the exciting future of DEL hit validation by focal Molography. 🌍💬 #DrugDiscovery #DELTechnology #Innovation #HitValidation #Molography #BIA

Great time at the 15th Swiss Course on Medicinal Chemistry in Leysin, organized by the #SwissChemicalSociety, where #SpiroChem is proud to be a sponsor! I’m attending alongside several colleagues* with the course chaired by our very own CSO, Gerhard Müller. This event offers a unique opportunity for young scientists, especially early-career medicinal chemists from pharma, to gain insights into the entire value chain of drug discovery. The speaker lineup is truly exceptional, featuring senior leaders with highly accomplished careers and recognized contributions to the field. Their lectures and tutorials provide invaluable knowledge—an ideal platform for the inter-generational transfer of expertise. As a key player in the drug discovery ecosystem, #SpiroChem is committed to advancing the tools and providing the support needed to tackle increasingly complex modalities and challenging targets. While new technologies like AI/ML are becoming central to modern drug discovery, it’s essential that the next generation of scientists not only master the core sciences but also learn how to critically engage with and challenge these tools. This is how we’ll develop the innovative medicines of tomorrow and make a real impact on patients’ lives. #drugdiscovery #medicinalchemistry #innovation #nextgen #SpiroChem #NobelPrizeChemistry2024 * Raquel Mato Santamaria Laurence Jung David Pierrot Quentin Lefebvre Benoit Carbain Gerhard Müller

Nice articulation of the data strategies needed to advance precision medicine for neurodegenerative diseases.

WuXi Biology launches a special edition of DNA encoded libraries in tubes, "DEL SE", which provides cost-effective access to 1.3 billion open-source structures for drug discovery players. Users are welcome to customize their experimental design and operation of DEL selection, coupled with WuXi Biology’s proprietary free-of-charge data decoding and visualization software. DEL SE is your ideal choice to quickly scan and prioritize potential targets, establish inhouse DEL capabilities, or accumulate protein-ligand interaction datasets. Questions? Contact us at discoverybiology@wuxiapptec.com #DEL #drugdiscovery #drugdevelopment #biotechnology #opensource #molecules #biotech #biopharm #targetproiritization #inhouseDELcapabilities #proteinligandinteraction

The East Coast 2024 Medicinal Chemistry Strategy Meeting welcomes Curia's James LaRocque, a leader in High-Throughput Screening (HTS), for a session exploring how this technology is pushing the boundaries of drug discovery. Jim currently leads a team developing cutting-edge screening platforms at Curia. His expertise spans areas like cellular imaging and label-free screening, techniques poised to revolutionize how we tackle previously undruggable targets. Jim leads us for a deep dive into the future of HTS, where we'll explore: 🔹 Engineered vs. traditional assays 🔹 Cellular vs. Biochemical HTS approaches 🔹 The power of label-free HTS 🔹 Emerging screening methods and their impact 🔹 The role of computational modeling in focused library design 🔹 Leveraging HTS for broader lead optimization Get ready for a thought-provoking discussion on how HTS is changing the game in drug discovery! #MedicinalChemistry #HTS #DrugDiscovery #UndruggableTargets #JamesLaRocque #Curia #EastCoastScience

📢 🌐 Exploring the Future of Drug Design through Computer-Aided Drug Discovery (CADD). Recently, I had the opportunity to attend a highly informative webinar titled "The Role of Computational Drug Design in Modern Biotechnology." Organized by Al_Faoz_Educational_Foundation, This interactive session offered valuable insights into how computational methods are transforming drug development and was divided into four sections. 🧪 Section I: Focused on traditional drug design methods, which come with significant challenges such as being time-consuming and resource-intensive, with limitations in screening capabilities. 💻💊 Section II: Introduced the core concepts of Computer-Aided Drug Discovery (CADD), explaining its workflow through flowcharts, and presenting key tools and techniques that are revolutionizing the field. 🔗 Section III: My favorite part—an in-depth dive into molecular docking! I gained a solid understanding of how it works and its practical applications, illustrated by helpful flowcharts. 💻➕🧫 Section IV: Explored the integration of computational techniques into modern biotechnology, emphasizing the skills needed to remain competitive in this evolving industry. #Biotechnology #CADD #Bioinformatics #MolecularDocking #ComputationalBiology #ComputationalDrugDiscovery

Supercharge your research with CyberX-SAR—a game-changer that enhances efficiency by 100x. exploration of potential drug targets , obtain structure-activity relationships, and visualize molecular clusters effortlessly. Step into the future of medicinal chemistry with AI-driven insights! #AIinMedicine #drugdiscovery #medicinalchemistry #AIInsights #FutureofChemistry #aifordrugdiscovery #PharmaInnovation #AIAdvancements #DrugDesign #CyberAIDD