Making sense of lipid profile: Illustrative example Which of the following two lipid profiles is associated with a HIGHER RISK of ischemic heart disease (heart attack)? 1. High LDL cholesterol, Low triglyceride, High HDL Cholesterol 2. Low LDL cholesterol, High triglyceride, Low HDL Cholesterol Answer as either 1 or 2 (in comments). State the reason, if you know.
Depending on gender, TG/HDL ratio can predict high cvd risk even in pts with low or borderline ldl
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Professor & HOD, Dept of Neurology, Apollo Hospitals, Hyderabad
2moThe correct answer is #2. A low TG–high HDL-C concentration is associated with a very low risk of IHD, whereas a high TG–low HDL-C concentration is a central risk factor of ischemic heart disease (IHD). The characteristic lipid abnormality seen in people with the metabolic syndrome is a lipid profile with high TG–low HDL-C levels, whereas a lipid profile with low TG–high HDL-C levels is the characteristic finding in people without this syndrome. Metabolic syndrome often consists of insulin resistance, obesity, atherogenic dyslipidemia, hypertension, diabetes, etc, all of which increase the risk of ischemic heart disease (IHD).