Drug Target Review’s Post

🚀#EMBLEM introduces you to: #Pan-cancer Biomarkers for Early #Tumor #Detection via #Liquid #Biopsy! 🚀 At EMBL, we're proud to introduce our groundbreaking technology for early cancer detection: 🔬 Technology Highlights: -Improved #biomarker to identify ALT pathway-driven #cancers -Enhanced resolution of TF #screening -Highly #specific, #reliable, minimally invasive #early #detection of cancer in #blood, now addressing cancers with high unmet clinical need -Comparable performance across all cancer stages -Potential companion diagnostic for ALT pathway-targeting drugs 🌟 Features: -Locally running machine learning classifier to predict cancer presence without the need for internet or database connections -Validated using ~10,000 whole #genome #sequencing datasets This innovation marks a significant leap forward in cancer diagnostics, offering new hope for early detection and treatment. Join us in our mission to revolutionize cancer #care! For more information click here: - https://lnkd.in/eRmZp4_u - https://lnkd.in/emc5FWHS This technology was co-invented by researchers from EMBL-EBI and CNIC. #CancerResearch #LiquidBiopsy #EarlyDetection #HealthcareInnovation #CancerDiagnostic #MachineLearning #EMBLEBI30 #EMBL50 #EMBLEM25 #EMBLEM Francesc Muyas Isidro Cortés Ciriano Julia Dieter European Bioinformatics Institute | EMBL-EBI

Specially designed nanocomplexes were found to significantly reduce tumour size in mice without harming vital organs 🔍 Building on momentum from a previous study, Yi Yan Yang of A*STAR Bioprocessing Technology Institute (BTI) led her colleagues and collaborators from the Bioinformatics Institute, A*STAR (BII), Institute of Molecular and Cell Biology (IMCB) and the IBM Almaden Research Centre in formulating next-generation nanocomplexes that effectively target and neutralise cancer cells. When tested on mouse models, they discovered that the treatment had successfully curbed the growth of both drug-susceptible and drug-resistant human breast cancer cells ✅ Recognising the potential impact of this innovation in drug delivery, Yang remarked: “Our anti-cancer polycarbonates may prevent or delay the development of cancer metastasis and drug resistance.” Head to the comments section for the link to the complete article 👇 --- #scicomm #science #technology #STEM #research #innovation #ASTAR #BTI #BII #IMCB #HHP #cancer #nanoparticles #drugdelivery #tumors

#CancerResearch | 𝗔 𝗡𝗲𝘄 𝗪𝗮𝘆 𝗼𝗳 𝗗𝗲𝘁𝗲𝗰𝘁𝗶𝗻𝗴 𝗠𝘂𝘁𝗮𝘁𝗶𝗼𝗻𝘀 𝗟𝗶𝗻𝗸𝗲𝗱 𝘁𝗼 𝗖𝗮𝗻𝗰𝗲𝗿 | Researchers at the University of Fribourg, led by Professor Curzio Ruegg, have achieved a significant breakthrough in cancer detection. They have developed ultrasensitive nanosensors capable of identifying cancer-associated nucleic acids and mutations, marking a major leap forward in medical diagnostics. Utilizing Primer Exchange Reaction-Based Signal Amplification and Flow Cytometry, this method enables rapid, simple, and cost-effective detection of cancer mutations in tumor tissues and blood samples. The research holds great promise for enhancing cancer detection accessibility for numerous patients. Sarah Cattin and Isabelle Gray contributed significantly to this cutting-edge study. 👉 Learn more >> https://lnkd.in/grJBNBHG 👉 Original publication >> https://lnkd.in/gkuaYK74 🇨🇭 Follow #ScienceSwitzerland for the latest news and emerging trends on Swiss science, technology, education, and innovation >> swissinnovation.org Follow us >> Science-Switzerland #Science | #Education | #Research | #Innovation

𝐅𝐨𝐬𝐭𝐞𝐫 𝐈𝐦𝐩𝐚𝐜𝐭𝐟𝐮𝐥 𝐃𝐢𝐬𝐜𝐮𝐬𝐬𝐢𝐨𝐧𝐬 𝐚𝐭 𝐈𝐦𝐦𝐮𝐧𝐨 𝟐𝟎𝟐𝟒! 🤝 Day One Track 4 is dedicated to the 'Discovery of Novel Targets in Immuno-Oncology: Identification, Validation & Exploration,' featuring insights from Mani Mudaliar, Massimiliano Mellone, Sophia N Karagiannis, Mark Cragg, Rick Kamps, and Amit Grover! 📚 This track is divided into two parts: 𝐏𝐚𝐫𝐭 𝟏 ✔️ Checkpoint inhibitors ✔️ Novel identification strategies ✔️ Emerging target identification and validation strategies, methods ✔️ Technological approaches: High-throughput screening, computational biology, genomic sequencing, CRISPR 𝐏𝐚𝐫𝐭 𝟐 ✔️ Solid tumours/tumour microenvironment ✔️ Case studies & latest developments in cellular therapies: NK Cells, Myeloid Cell, Stem Cells (MSCs, HSCs, PSCs/iPSCs ➡️📖 Explore the exciting agenda: https://hubs.la/Q02jQ1j-0 #OGImmuno #Immuno24 #NovelTargets #TumourMicroenvironment

#citations A recent study employs a well-established reporter cell system to demonstrate high potency of iCAR constructs harboring BTLA-derived signaling domains. The researchers find that the iCAR failed to veto immediate CAR-mediated cytotoxicity. Likewise, T cells overexpressing PD1 or BTLA did not show impaired cytotoxicity towards ligand-expressing target cells, indicating that inhibitory signaling by these receptors does not mediate protection against cytotoxicity by CAR-T cells. Future approaches employing iCAR-equipped CAR-T cells for cancer therapy should therefore monitor off-tumor reactivity and potential CAR/iCAR-T cell dysfunction. Read the paper here: https://lnkd.in/eZkM4mPw Congrats to all contributors! Medical University of Vienna GenScript is thrilled to provide molecular biology service to this amazing research. Check out more: https://lnkd.in/e4XCMhex #cart #cartcelltherapy #newpaper #researchadvance #biologyfront

🔊 Weekly round-up!   👩🏻🔬Women in STEM with Leila Jaafar As CEO of NUCLIDIUM AG, Leila Jaafar focuses on shaping, and the execution of, its international strategy towards its primary goal of improving the availability and affordability of radiopharmaceuticals in cancer diagnosis and therapy worldwide. 💊Breakthrough for pancreatic cancer treatment University of California, San Francisco researchers have designed the first small molecule drug targeting K-Ras GD12, which could improve pancreatic cancer outcomes.   🧫Recurrent urinary tract infections: potential cause discovered Duke University School of Medicine researchers find that an overgrowth of nerve cells in the bladder could cause rUTIs, which may offer new approaches to manage symptoms.   🧠Brain organoids: essential ethical investigation Scientists from the Institute for the Advanced Study of Human Biology (ASHBI) have provided important insights for the ethical landscape of brain organoid research, as advances in neuroscience have prompted new considerations.   Click on the links in the comments to read more! 👇   #drugdiscovery #lifescience #drugtargets 

Save up to $200 on Regular Registration Rates for #SITC 2024 by registering by tomorrow, August 14! SITC 2024 will feature the Immune Engineering Workshop: Building Bridges Between All Aspects of Engineering and Immuno-oncology. This program is one of the Pre-Conference Programs that will be held on Thursday, Nov. 7, 2024 in Houston, TX. The Workshop will explore the recent advances in #engineering, artificial intelligence, and cancer #immunology and how these fields can converge to effectively address current hurdles in immuno-oncology. Practical solutions to clinical problems via interdisciplinary collaboration between #engineers, #clinicians, and #scientists will also be discussed. To save on early registration, visit: go.sitcancer.org/3SkAKFH Program Organizers: Daniel Chen, M.D. Ph.D. - Synthetic Design Lab, Inc., Elana Fertig, PhD, FAIMBE - The Johns Hopkins University, Kole Roybal, PhD - University of California, San Francisco, Stefani Spranger, PhD - MIT Koch Institute for Integrative Cancer Research. #ai #immunooncology #cancerresearch #cure #cancer #immunotherapy

🔬 Thrilled to share my research on "Microbiome-Modulated Cancer Therapy: Unveiling the Potential of Microbial Influence in Oncology"! 🌟 In my study, I explored the emerging field of microbiome research and its profound implications for cancer treatment. As a biology student fascinated by the intersection of biology and technology, I investigated how advances in biotechnology and bioinformatics are revolutionizing our understanding of microbial communities and their impact on cancer progression. Recent studies have shown that the human microbiome plays a pivotal role in modulating immune responses and drug metabolism, influencing cancer outcomes. Leveraging technologies like next-generation sequencing and computational biology, researchers can now analyze complex microbiome data to identify therapeutic targets and develop personalized treatment strategies. I am passionate about harnessing these technological advancements to contribute to innovative cancer therapies that harness the power of the microbiome. Let's continue to push the boundaries of biological research and technology integration for improved patient outcomes in oncology! #MicrobiomeResearch #CancerTherapy #Biotechnology #Bioinformatics #BiologyAndTechnology #ResearchHighlight #LinkedInPost 🧬

⛑️ Cancer-shattering jackhammers tl;dr: Researchers have discovered a new technique using Aminocyanine molecules that transform into 'molecular jackhammers' when stimulated by near-infrared light. These vibrating molecules have shown remarkable efficacy in destroying cancer cells, offering hope for more effective and non-invasive treatments. * * * 👷🏽♂️ Innovation doesn't always roar; sometimes, it hums. Researchers from Rice University, Texas A&M University, and the University of Texas are harnessing the power of vibrating molecules, whose gentle yet relentless hum has the potential to obliterate cancer cells, paving the way for a future where invasive surgeries become relics of the past. Their weapon of choice is Aminocyanine molecules - synthetic dyes commonly used in bioimaging. When stimulated by near-infrared light, these molecules transform into 'molecular jackhammers,' vibrating in sync to rupture cancer cell membranes. In laboratory tests on cultured cancer cells, this technique demonstrated an astounding 99% efficacy rate. Even more encouragingly, it showed tangible results when tested on mice with melanoma tumors. But what makes this method truly revolutionary is its potential to outsmart cancer's notorious ability to develop resistance. Unlike chemical treatments, this biomechanical approach presents a formidable challenge for cancer cells to overcome. 🚀 What I love with this research is that it reimagines and repurposes something that we already have. I wonder to which extent AI will help us find new uses for existing molecules, materials and processes? #InnovationInHealthcare #CancerResearch #innovation #future #repurposing Image credit: Texas A&M University

🔬Researchers at Purdue University have made a groundbreaking discovery that could revolutionize treatments for cancer and inflammatory diseases. Led by Professors John Tesmer and Qing Deng, the team has uncovered how the protein PI3Kγ plays a crucial role in cell signaling pathways, which govern immune responses and cancer metastasis. Utilizing advanced cryo-electron microscopy, they revealed the activation mechanism of PI3Kγ, opening doors to targeted therapies that could inhibit the spread of cancer cells or reduce inflammation in chronic diseases. This study, published in Nature Structural and Molecular Biology, highlights Purdue's commitment to innovative research and cross-disciplinary collaboration, paving the way for new therapeutic approaches and improved patient outcomes. #PurdueResearch #Biotechnology #CancerResearch #BiomedicalInnovation #CryoEM #HealthcareBreakthroughs Read more: https://lnkd.in/eCxeW7xA