EASD e-Learning reposted this
Senior Medical Officer (Diabetes & Obesity), Novo Nordisk; Professor of Endocrinology, University of Copenhagen
Big congrats to Henriette Holst Nerild et al.* for publishing this one in Diabetes, Obesity and Metabolism 👏🤩👊 "Elucidating the glucose-lowering effect of the bile acid sequestrant sevelamer" Bile acid sequestration is recommended for the treatment of type 2 diabetes, but little is known about the mode of action. Using the bile acid sequestrant sevelamer and the GLP-1R antagonist exendin(9-39)NH2 in a randomized, double-blind, placebo-controlled, crossover design, Henriette Holst Nerild et al. show that sevelamer improved insulin sensitivity and beta cell sensitivity to glucose in patients with type 2 diabetes and that the latter effect was GLP-1-dependent. https://lnkd.in/dsjDsMVW *Andreas Brønden, Abdullah E. Haddouchi, Anne Marie Gade Ellegaard, Bolette Hartmann, Jens F. Rehfeld, Jens Juul Holst, David P. Sonne, MD PhD, Tina Vilsbøll, Filip K. Knop
