EASL | The Home of Hepatology’s Post

⭐️Case Report: Thyroid Carcinoma Showing Thymus-like Differentiation (CASTLE): A Case Report. 🎓by Dr. Popescu, Dr. Vasile et al., from University of Medicine and Pharmacy of Craiova and Marie Curie Emergency Children’s Hospital. 📄Enjoy reading: https://lnkd.in/et9-zidP #thyroid carcinoma; #immunohistochemistry; #thyroidectomy; #thymus-like differentiation

Precision medicine in patients with glioblastoma: again another of our great examples of effectiveness! https://lnkd.in/dpM64q-p Istituto Oncologico Veneto IOV - IRCCS #glioblastoma EANO European Association of Neuro-Oncology SNOLA Society for Neuro-Oncology Latin America

Exciting advancements in cardiac research! A new study by Alicia R. Lane and colleagues has introduced a groundbreaking maturation protocol for human cardiac organoids (hCOs) called "directed maturation" (DM-hCO). By activating specific signaling pathways, this approach significantly enhances the functionality and metabolic properties of hCOs, including improved mitochondrial respiration. Leveraging #Resipher's capabilities, the study enables the use of standard culture media while maintaining these enhancements over several days. This innovation not only provides more realistic models for cardiac disease and drug discovery but also successfully modeled desmoplakin cardiomyopathy, paving the way for potential therapeutic strategies. A major leap forward in our understanding of heart disease and treatment! Check out the full study here: https://lnkd.in/dtWfQfVn

This research by Alicia R. Lane, Noah E. Scher, Shatabdi Bhattacharjee, Stephanie A. Zlatic, and colleagues revolutionizes the development of human cardiac organoids (hCOs) by creating a novel maturation protocol that more closely mirrors the human heart's developmental journey. This protocol, termed "directed maturation" (DM-hCO), involves strategically activating AMPK and ERR signaling pathways, resulting in hCOs with enhanced functionality and metabolic properties. These DM-hCOs demonstrate a robust increase in mitochondrial respiration, a key hallmark of mature cardiac tissue. The study leverages the unique capabilities of #Resipher, allowing the use of standard cell culture media, to demonstrate that this enhanced mitochondrial respiration persists over multiple days, making it ideal for studying complex, long-term processes in the heart. This advancement paves the way for more realistic and physiologically relevant models for cardiac disease and drug discovery. In fact, the researchers successfully modeled desmoplakin cardiomyopathy, a challenging human genetic disease, and identified potential therapeutic strategies using this innovative DM-hCO model. This work represents a crucial leap forward in employing hCOs as robust tools for disease modeling and drug development. View it here: https://lnkd.in/dtWfQfVn #CardiacOrganoids #hCOs #CardiacDiseaseModeling #DrugDiscovery #Cardiomyopathy #MitochondrialRespiration #StemCellResearch

Polarean Imaging PLC (AIM:POLX, OTC:PLLWF) said it has agreed a trade-in deal with the University of Kansas Medical Center (KUMC) for a new clinical-grade Xenon MRI hyperpolariser system. KUMC, a leading academic centre in xenon MRI research, will exchange its existing hyperpolariser for the latest FDA-approved system provided by Polarean. The new equipment will support KUMC's studies in areas such as asthma, cystic fibrosis, long Covid, pulmonary hypertension, interstitial lung disease, and scleroderma. KUMC's Dr Peter Niedbalski recently received a grant to lead a multi-centre study using xenon MRI to explore the structural causes of low lung function and respiratory symptoms in young adults. Polarean plans to install the new technology later this year, collaborating with KUMC to enhance clinical imaging and support NIH-funded research and pharmaceutical-sponsored trials.  "The team at KUMC has been a valued... More at #Proactive #ProactiveInvestors http://ow.ly/fe4Q105CQu2

Deepika Kumar, MD, and team: Elad Neeman, MD, Shiyun Zhu, MPH, Hongxin Sun, MS, Dinesh Kotak, MD, and Raymond Liu, MD, collaborated with the San Francisco Internal Medicine Residency Program, Kaiser Permanente Northern California Residency and Fellowship Programs and Kaiser Permanente Division of Research to answer this important public health question.  Article: https://lnkd.in/gqCJGaFK Citation: Kumar D, Neeman E, Zhu S, Sun H, Kotak D, Liu R. Revisiting the Association of ECOG Performance Status With Clinical Outcomes in Diverse Patients With Cancer. J Natl Compr Canc Netw. 2024 Apr 23;22(2D):e237111. doi: 10.6004/jnccn.2023.7111. PMID: 38653321.

Fascinating read, especially about the association of ECOG status and outcomes in different cancers. Interesting use of real world data.

"We feel every older adult deserves a personalized approach to their care, and geriatric assessment is a key strategy to make that happen." - Dr. Allison Magnuson and Dr. Melissa Kah Poh Loh of University of Rochester School of Medicine and Dentistry ICYMI: A new #OpenAccess review in CA: A Cancer Journal for Clinicians offers clinicians essential guidance for using geriatric assessment (GA) to enhance cancer care for older adults. GA can help predict outcomes, tailor interventions, and improve overall quality of life while reducing treatment-related complications. Access the full article here: https://lnkd.in/epH-2Frd Cancer and Aging Research Group (CARG)

📣Happy to share the Special Issue “Contrast-Enhanced Ultrasound in the Diagnosis, Treatment and Surveillance of Hepatocellular Carcinoma ” edited by Prof. Dr. Radu Ion Badea and Dr. Lidia Ciobanu is open for submission❗️ University of Medicine and Pharmacy "Iuliu Hațieganu", Cluj-Napoca ⏳Deadline for manuscript submissions: 20 November 2024. 📌Find more details here: https://lnkd.in/d779G2pz ♦️This Special Issue is dedicated to CEUS in HCC, aiming to encourage discussions regarding all the challenges faced by clinicians and the presentation of research on how to manage all the stages of HCC, from diagnosis to treatment and surveillance. We also encourage the submission of papers regarding differential diagnosis with other tumors developed both on cirrhotic and noncirrhotic liver (MAFLD), focusing on imaging aspects and vascular patterns♦️

Honoring World Brain Tumor Day Today, on World Brain Tumor Day, we come together to honor the courage and strength of those affected by brain tumors. This day is dedicated to raising awareness, supporting research, and standing in solidarity with patients, families, and healthcare professionals. 🧠 What You Should Know: Brain Tumors: A complex and challenging condition that affects countless lives worldwide. Awareness & Education: Understanding symptoms and early detection can save lives. Research & Innovation: Continuous advancements in medical research are crucial for better treatments and hope for a cure. Join us in recognizing the incredible resilience of the brain tumor community. Let's amplify our efforts to support research, share knowledge, and inspire hope. #WorldBrainTumorDay #BrainTumorAwareness #Healthcare #SupportResearch #HopeForACure