Empire Genomics’ CRLF2 Break Apart FISH Probe is designed to detect rearrangement of the CRLF2 gene at chromosomal regions Xp22.33 and Yp11.32. Overexpression of Cytokine Receptor-Like Factor 2 (CRLF2) has been found in approximately 50% of Ph-like B-ALL cases. This overexpression has been linked to translocations involving IGH, t(X;14) or t(Y;14). Rearrangements involving CRLF2 are extremely prevalent in children with Down syndrome-associated B-ALL (DS-ALL) with 30%-50% of DS-ALL children having a CRLF2 rearrangement. In contrast only 5%-10% of ALL patients without Down syndrome have this rearrangement. Let us know which FISH Probes you want to see next! Search Over 1 Million Biomarkers - CRLF2 Break Apart FISH Probe - https://lnkd.in/dgGcXTKA
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Integrin Subunit beta 3 (ITGB3) is abundantly expressed on platelets and megakaryocytes and has a high affinity for fibrinogen. In activated platelets, plasma fibrinogen binds to alpha IIb/beta 3 and allows platelet-to-platelet crosslinking. Mutations of the ITGB3 gene are associated with Glanzmann thrombasthenia, a condition of impaired platelet plug formation and bleeding. Learn more about the testing with Medical Database. https://lnkd.in/gD54UT4S #medicaldatabase
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What is PathogenDx D3 Array™-UTI? A fast multiplexed testing solution for urinary pathogen detection run simultaneously with antibiotic resistance gene markers. This novel highly multiplexed UTI assay provides a scalable, low cost solution in a single test with results in under 6.5 hours. Read the the more thorough technical breakdown in the whitepaper from Clinical Advisor Dr. Sue Evans here ---> https://loom.ly/WwKvYR4
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DISP1 deficiency: monoallelic and biallelic variants cause a spectrum of midline craniofacial malformations. #RareDisease #Genetics A total of 23 DISP1 variants were identified in heterozygous, compound heterozygous or homozygous states in 25 individuals with midline craniofacial defects. Most cases were minor forms of holoprosencephaly (HPE), with craniofacial features such as orofacial cleft, solitary median maxillary central incisor, and congenital nasal pyriform aperture stenosis. These individuals had either monoallelic loss-of-function variants or biallelic missense variants in DISP1. Their observations led them to believe that the severe HPE is caused by combination of a DISP1 variant with an additional alteration in an HPE-linked gene. Half of the individuals with severe HPE in this study were found to carry an additional variant or copy number variation involving an HPE-linked gene (e.g., SHH, PTCH1, SIX3). This observation suggests that some DISP1 variants are only pathogenic in oligogenic combinations, since it has been established that HPE has oligogenic inheritance. https://lnkd.in/d8TCFkum
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WEBINAR ALERT! Join us for an insightful session with Jessica Koepke and João Cotovio to discover the applications of Ncyte® aCardiomyocytes in toxicity, and gene modulation assays. In this webinar, you will learn about the quality control and characterization of Ncyte® aCardiomyocytes, as well as examples of their applications in drug discovery and the advantages of using chamber-specific cardiomyocytes. Don't miss out on this opportunity to learn from experts in the field! Choose the session that best fits your time zone: For our European audience: Wednesday, August 28th at 3:30 PM CEST Register here: https://lnkd.in/dVeqGTNX For our US audience: Wednesday, August 28th at 1:00 PM ET Register here: https://lnkd.in/d4c72SJy Secure your spot and gain valuable insights! #Webinar #Cardiomyocytes #cardiacdisease #DrugDiscovery #CellBasedAssay #Ncardia
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LC and CP effects on oocyt! In a study published in IJRM, researchers evaluated the effects of L-carnitine on mice treated with the CP anticancer drug, which causes infertility in women. The study found that LC reduced levels of ROS, increased expression of the Bcl2 gene, and decreased expression of the Bax and Caspase3 genes in oocytes. These findings suggest that LC can protect against CP-induced infertility in mice by reducing ROS and modulating the apoptotic pathway. Read more: https://lnkd.in/drTVpqib
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Senior Director of BD @ Ncardia | iPS cells for drug discovery & cell therapy | Follow for biotech content 🔔
WEBINAR ALERT! Tune in for an insightful session with my colleagues Jessica Koepke and João Cotovio to discover the applications of Ncyte® aCardiomyocytes in toxicity and gene modulation assays. In this webinar, you'll learn about the quality control and characterization of Ncyte® aCardiomyocytes, as well as examples of their applications in drug discovery and the advantages of using chamber-specific cardiomyocytes. Don't miss out on this opportunity to learn from experts in the field! Choose the session that best fits your time zone: For my European connections: Wednesday, August 28th at 3:30 PM CEST For my US connections: Wednesday, August 28th at 1:00 PM EDT Registration links in the comments below ⬇ #Cardiomyocytes #cardiacdisease #DrugDiscovery
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Just came across an interesting article that highlights some exciting new developments in the industry. It's always fascinating to see innovative approaches and fresh perspectives shaping our field. Highly recommend giving it a read! #Innovation #IndustryNews #ExcitingDevelopments #ProfessionalGrowth #crohnsandcolitiscanada
A breakthrough in IBD research: By studying “junk” DNA, researchers were able to identify a new gene, ETS2, as a key driver of inflammation. This may lead to new treatment options and ways to address underlying causes of Crohn’s disease and ulcerative colitis. To learn more about this discovery, head to our website bit.ly/3XsXyqf
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Discover the power of precision with our UBA1Q assay, targeting seven possible mutations that can occur in the UBA1 gene to diagnose VEXAS syndrome accurately. Read more. https://bit.ly/4fjQPEP
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Blood Gene Signature as a Biomarker for Subclinical Kidney Allograft Rejection: Where Are We? #An important literature review on the value of biomarkers in diagnosing subclinical kidney allograft rejection. #kidneytransplantation #reviewpaper# tinyurl.com/3323fpun
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Ready to get your mind blown? Just because you have the Sickle Cell gene does NOT ❌ guarantee your children will have Sickle Cell Disease! 🤯 We know it takes two to tango, so for your child to end up with Sickle Cell anemia, both parents have to carry the Sickle Cell gene. There's a 25% chance neither parent passes on the Sickle Cell gene, but there is a 75% chance that the child will end up with at least one copy of it. Remember: It takes two copies of the gene to produce Sickle Cell anemia. Join us for a Sickle Cell webinar on September 25 from 12 - 1 p.m.! Find the info and registration link at https://lnkd.in/gEXp7RQy. #SickleCell #SickleCellAwarenessMonth #SickleCellAwareness #SickleCellDisease #SickleCellTrait #SickleCellAnemia
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