Emulate, Inc.’s Post

Addressing the Rising Global Challenge of Age-Related Macular Degeneration (AMD)! As the world prepares for an aging population, the number of people affected by age-related macular degeneration (AMD) is set to increase dramatically. By 2050, an estimated 30.44 million in Asia and millions more across Europe and North America will face this life-altering condition. At Cirrus Therapeutics, cofounded by Dr. Ying Kai Chan Chan and Dr. Andrew Dick, we're at the forefront of pioneering a first-in-class treatment that targets the root causes of AMD through a novel approach involving the IRAK-M protein. Our innovative gene therapy not only addresses multiple pathological pathways but also aims to sustain the health of retinal cells far more effectively than current treatments. Stay tuned as we advance towards clinical trials and beyond. We are committed to transforming the landscape of ocular health and offering new hope to millions. Follow our journey and be part of the future where vision loss is no longer an inevitable part of aging. #vision #AMD #DryAMD #WetAMD #optometry #ophthalmology #healthcare #innovation #science #research #termeerfellow #biotech #STEM

Focus on #stemcells #research with Bio-protocol! (Series3_Post10) https://lnkd.in/dG-KVPpJ A reliable transgene-free protocol for generating human skeletal muscle stem cells from hiPSCs. The two-step process includes: 🔹 Differentiation of hiPSCs into myocytes (iMyoblasts, characterized as PAX3+/MyoD1+ myogenic stem cells) using small molecules. 🔹 Activation and expansion of undifferentiated reserve cells with growth factor-rich medium to establish cell lines. This robust method has been applied to model Facioscapulohumeral Muscular Dystrophy and Limb-Girdle Muscular Dystrophies, enabling efficient gene editing. Work by Dongsheng Guo, Katelyn Daman, Danielle Fernandes Durso, Jing Yan and Charles Emerson at UMass Chan Medical School. Follow Bio-protocol to stay updated on the latest advancements in life-science research.

Germany’s biotech industry on the rise: The latest report by EY and BIO Deutschland e. V. highlights a promising first half of 2024, with venture investments in German biotech reaching €494 million—already 93% of last year’s total. Explore the German Biotechnology Report 2024 here: https://lnkd.in/e8AH7WtH A new aging atlas from Howard Hughes Medical Institute (HHMI)’s Janelia Research Campus offers a detailed look at how cells and tissues in worms age. This comprehensive atlas maps gene expression changes, providing insights that could pave the way for innovative anti-aging treatments: https://lnkd.in/errCRzHc New research at the University of Wisconsin-Madison outlines how protein restriction in a mouse model of Alzheimer’s slows disease pathology, promotes metabolic health, and extends lifespan. The study observed significant benefits, particularly in female mice, demonstrating reduced disease markers and enhanced cognitive performance, potentially offering a new dietary intervention approach to combat Alzheimer’s: https://lnkd.in/eedZKrWu #ICYDK #ApolloVC #Lifespan #Healthspan #Longevity #VentureCapital

||Themes of the Lectures and Grand Roundtable of the IV OBS|| We present to you this year’s themes for the Lectures and Grand Roundtable of our Scientific Programme, which will embark you on a journey of discovery! We warmly invite our participants to engage in thought-provoking lectures and discussions. Stay tuned for more informations about our Scientific Programme and it’s renowned speakers! Trust your gut: a lecture focusing on the bidirectional communication between the central and the enteric nervous system, as well as new possibilities for treatment. Tiny wonders, big challenges: a complete lecture focusing on different congenital malformations and the advances in treatment. Kidneys without borders: a lecture on the technicalities and bureaucracy behind renal (and crossed) transplantations, focusing on the South Alliance for Transplants, as well as surgical advances. Grand Roundtable: A discussion on Gene Editing, Eugenics, and the Ethical Considerations of Designer Babies

eGenesis, Inc. a pioneer in genetic editing, secures $100M to revolutionize organ transplantation! 🧬💉 With the groundbreaking success of rendering pig organs safe for transplant, eGenesis CEO Michael Curtis is pioneering genetic editing to make pig organs safe for human transplant. The recent transplant of a genetically edited kidney at Massachusetts General Hospital marks a pivotal moment. Patient Richard Slayman's recovery highlights the transformative potential of this technology. 💪 eGenesis estimates over 800,000 Americans suffer from renal failure, with a staggering 90,000+ on the waitlist for kidneys annually. This innovation could alleviate immense suffering and save lives. #egenesis #geneticediting #biotech #innovation #technology #healthcare

New Medical Article! This is article 1 of a Herpes-based gene therapy treats dystrophic epidermolysis bullosa series. Have you ever plucked loose skin near your nail, ripping off a tiny strip of good skin too? Albeit very small, that wound can be painful. Now imagine that it is not just a little strip that peels off, but an entire sheet. And it does not detach only when pulled, but at the slightest touch. Even a hug opens wounds, even a caress brings you pain. This is life with recessive dystrophic epidermolysis bullosa (RDEB), the most severe form of dystrophic epidermolysis bullosa (DEB)…….. Read the rest of the article: https://lnkd.in/eUQxMKvn Written by: Matteo Cortese, PhD #medical #skin #article #website #phd #science #medicine #disease Medical Research Council Health Education England

Scinus Cell Expansion B.V. has been recognized as one of the Top Cell And Gene Therapy Company In Europe  by Life Sciences Review. SCINUS Cell Expansion not only demonstrates superior efficiency; it also champions sustainability. Conventional methods of stem cell cultivation frequently lead to considerable media wastage, necessitating repetitive harvesting and reseeding into new flasks, discarding media that could still be utilised. In sharp contrast, the SCINUS bioreactor NG introduces a method for refreshing the medium within the same cultural environment. This innovation reduces media consumption by up to 60 percent for the same yield of cells, minimising waste. Such efficiency aligns with broader environmental goals, like those outlined in the European Green Deal, by reducing the overall impact of scientific research on the environment. "Operating within a closed system, the SCINUS Bioreactor NG ensures compatibility with Class C or D cleanrooms. This simplifies operational procedures and significantly diminishes the overall cost of ownership, marking a pivotal departure from the more labor-intensive methods of cell culture." says Michiel Jannink, CEO. The article will also be featured in the forthcoming special print edition on Cell And Gene Therapy 2024. Read More : https://lnkd.in/gpjKHRCn #bioreactortechnology #cleanroominfrastructure #mediaconsumption

📢 A new Special Issue "Applications of Gene Therapy for Biomedical Engineering" is now open for submissions! 🥼 This Special Issue is Guest Edited by Dr. Nan Yang. 💡 This Special Issue addresses this critical need by consolidating insights from global experts in gene therapy, retinal biology, and bioprocess engineering. Together, these contributions present significant advances in the engineering sciences, driving the successful implementation of gene-based therapies for retinal degeneration and paving the way for transformative breakthroughs in ocular healthcare. 🔗 Click the link to access more details about the Special Issue: https://lnkd.in/gDFZ8vvZ 🕑 Deadline for manuscript submissions is 30 April 2024. 🎉 Welcome to join us as authors and reviewers! 👏And welcome to follow our LinkedIn account: https://lnkd.in/grPNkBrg. #retinal_degeneration #genetherapy #targeted_biological_therapies

A gene regulating fat storage identified! To identify genetic factors responsible for fat deposition, the researchers analyzed gene expression data from fat tissue compared with other tissue types. The results showed that HSP47, a collagen-specific molecular chaperone, is a significant determinant of body fat levels. “HSP47 is expressed at high levels in fat tissue and increases with obesity and greater food intake; in contrast, its expression level decreases with fasting, exercise, calorie restriction, bariatric surgery, and wasting syndrome,” explains the senior author. “In addition, HSP47 expression correlates closely with fat mass, body mass index, waist circumference, and hip circumference.” Importantly, the researchers found that insulin, a hormone associated with fat storage or fat loss, increases HSP47 expression levels; while conversely, glucocorticoids decrease HSP47 expression levels. In addition, high or low HSP47 expression was linked to high or low body fat levels in both humans and mice. #ScienceMission #ScienceNewsHighlights https://lnkd.in/dYTsKesN

The biotechnology industry is revolutionizing medical treatments through innovations like targeted therapies, personalized medicine, gene therapy, regenerative medicine, and advanced diagnostics. These advancements are transforming healthcare, offering new hope for patients with previously untreatable conditions and improving treatment efficacy. As biotech continues to evolve, its impact on medicine will grow, paving the way for precision medicine and a healthier future. https://lnkd.in/dKHHUvgT #Biotechnology #MedicalInnovation #GeneTherapy #RegenerativeMedicine #TargetedTherapies #PersonalizedMedicine #AdvancedDiagnostics #Healthcare #PrecisionMedicine #MedicalResearch Amit Kar