ERN-RITA’s Post

🤗 📝 We are happy to share this article from a group of French autoinflammatory experts, including representatives of the Tenon Hospital (RITA member since 2022). It describes the first dominant somatic mutation of MEFV p.Thr577Ala, responsible for a pyrin-associated autoinflammatory disease. Have a read! ⬇ https://lnkd.in/dedcMnND

Nucleosome/NETs-ICs bind to heparan sulfate in the GBM of patients with active LN and can likely be removed from the blood when persistently elevated utilizing covalently immobilized heparin blood purification. "These findings suggest that nucleosome-mediated binding of autoantibodies to basement membranes may also occur at sites in the body other than in the glomerulus". Deposition of nucleosomal antigens (histones and DNA) in the epidermal basement membrane in human lupus nephritis. https://lnkd.in/ekxEhW-q Berden

Today, February 29, is Rare Disease Day. A rare disease is generally considered to be a disease that affects fewer than 200,000 people in the United States at any given time. There are more than 6,800 rare diseases. Altogether, rare diseases affect an estimated 25 million to 30 million Americans. At Inova, our genetic counselors and physicians from Inova’s genetic aortopathy team and Inova’s cardiogenetics program help our patients find and treat the root cause of thoracic aortic disease. Heritable thoracic aortic disease and related conditions such as Marfan Syndrome, Loeys-Dietz Syndrome, and vascular Ehlers Danlos Syndrome are examples of rare diseases in which early recognition and timely treatment helps to prevent catastrophic and life threatening aortic dissection. https://lnkd.in/e-NuVNVe

#KnowLPa LP(a) awareness day march 24 Lipoprotein(a) is a low-density lipoprotein variant containing a protein called apolipoprotein(a). Genetic and epidemiological studies have identified lipoprotein(a) as a risk factor for atherosclerosis and related diseases, such as coronary heart disease and stroke Current guidelines recommend that patients with a moderate or high risk of cardiovascular disease should have their Lp(a) levels checked. Any patient with one of the following risk factors should be screened: -premature cardiovascular disease -familial hypercholesterolaemia -family history of premature cardiovascular disease -family history of elevated Lp(a) -recurrent cardiovascular disease despite statin treatment -at least once in the lifetime of each adult person International Atherosclerosis Society (IAS)

The Composition of the Fecal and Mucosa-adherent Microbiota Varies Based on Age and Disease Activity in Ulcerative Colitis

【Cited FineTest ELISA Kit】Cytokine ELISA Kit | Annals of the Rheumatic Diseases | IF: 27.4 Abstract: FineTest TNF-α ELISA Kit is cited by an article entitled "Single-cell transcriptome analyses reveal disturbed decidual homoeostasis in obstetric antiphospholipid syndrome" Published in Annals of the Rheumatic Diseases. (Read Full Text: https://bit.ly/4caJcQ9) Keywords:  #Obstetrics, #AutoimmuneDisease, #Autoimmunity, #Inflammation, #ImmuneHealth

Accurate diagnosis of monogenic inflammatory bowel disease can be challenging due to similar features with polygenic IBD. Learn how our testing provides a definitive diagnosis. https://bit.ly/3QQl8t1

New review article out on the challenges associated with using #extracellularvesicles as #biomarkers in #neurodegenerative disease. Enjoy! https://lnkd.in/etyfDQEh

Lupus is one of the autoimmune diseases for which Car-T holds so much promise, but stubborn barriers of cost and supply constraints have kept it from helping more patients. Cellares is one of the companies helping to break them down, as Oliver Barnes of Financial Times explores in an inspiring story on a life turned around by Car-T. https://lnkd.in/gxs7ssg4 #celltherapy

News in advancements in IBD Care! A recent study emphasizes the importance of testing for fecal Calprotectin to identify levels of gut inflammation levels and predict long-term disease outcomes. Calpro Products Highlighted: This study relied on the Calpro Easy Extract and CalproLab ELISA to extract and analyze stool samples for fecal calprotectin (fCal). This accurate assessment aids in understanding inflammatory activity within the gut. This study highlights the potential of fCal and fecal myeloperoxidase (fMPO) as complementary tools for assessing disease during regular clinical care. By utilizing a combination of fecal biomarkers (e.g. fCal), CRP, and clinical disease activity, it is possible to identify individuals who are at risk of developing IBD complications. Read the full article https://hubs.ly/Q02pXT5S0 #IBD #MedicalResearch #PatientCare #CalproELISA #answersinlifescience #Crohns #Ulcerativecolitis