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📃Scientific paper: A translational study of the link between Alzheimer's disease, sleep and epilepsy : prevalence, underlying factorsand consequences on memory consolidation;Etude translationnelle du lien entre la maladie d'Alzheimer, le sommeil et l'épilepsie : prévalence, facteurs sous-jacents et conséquences sur la consolidation mnésique Abstract: With more than 30 million people diagnosed worldwide, Alzheimer's disease (AD) is the most frequent neurodegenerative disorder. Previous research on murine models of AD highlighted the potential role of cerebral excitatory-inhibitory imbalance in the pathophysiology of AD. Clinical research has since reported that it may give rise to epileptic activities in as much as 50% of AD patients. However, these epileptic events may remain undetected due to their silent, mostly sleep-occurring nature. Therefore, the first part of this project corresponded to a preclinical study in which we aimed at (I) characterizing epileptic activities over the sleep-wake cycle in the Tg2576 mouse model and (II) gaining better insight into the mechanistic underpinnings of these peculiar epileptic events. Tg2576 mice displayed frequent epileptic activities that were predominant during REM sleep and highly locked to the phase of the theta cycle corresponding to the maximal firing probability of pyramidal cells, hinting at a potential deficit of inhibitory activity leading to hyperexcitability - which is coherent with previous results in our laboratory. Secondly, this epileptic activity seems to be prevented during wakefulness - and partially during slow-wave sleep - by noradrenergic signalling via alpha1 adrenoreceptors. In contrast, EA would be unmasked during REM sleep when noradrenergic cells cease firing. Given the early degeneration of the locus coeruleus - the primary source of noradren... Continued on ES/IODE ➡️ https://etcse.fr/hrg ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you. #alzheimer #science #health

📃Scientific paper: A translational study of the link between Alzheimer's disease, sleep and epilepsy : prevalence, underlying factorsand consequences on memory consolidation;Etude translationnelle du lien entre la maladie d'Alzheimer, le sommeil et l'épilepsie : prévalence, facteurs sous-jacents et conséquences sur la consolidation mnésique Abstract: With more than 30 million people diagnosed worldwide, Alzheimer's disease (AD) is the most frequent neurodegenerative disorder. Previous research on murine models of AD highlighted the potential role of cerebral excitatory-inhibitory imbalance in the pathophysiology of AD. Clinical research has since reported that it may give rise to epileptic activities in as much as 50% of AD patients. However, these epileptic events may remain undetected due to their silent, mostly sleep-occurring nature. Therefore, the first part of this project corresponded to a preclinical study in which we aimed at (I) characterizing epileptic activities over the sleep-wake cycle in the Tg2576 mouse model and (II) gaining better insight into the mechanistic underpinnings of these peculiar epileptic events. Tg2576 mice displayed frequent epileptic activities that were predominant during REM sleep and highly locked to the phase of the theta cycle corresponding to the maximal firing probability of pyramidal cells, hinting at a potential deficit of inhibitory activity leading to hyperexcitability - which is coherent with previous results in our laboratory. Secondly, this epileptic activity seems to be prevented during wakefulness - and partially during slow-wave sleep - by noradrenergic signalling via alpha1 adrenoreceptors. In contrast, EA would be unmasked during REM sleep when noradrenergic cells cease firing. Given the early degeneration of the locus coeruleus - the primary source of noradren... Continued on ES/IODE ➡️ https://etcse.fr/hrg ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you. #alzheimer #science #health

📃Scientific paper: A translational study of the link between Alzheimer's disease, sleep and epilepsy : prevalence, underlying factorsand consequences on memory consolidation;Etude translationnelle du lien entre la maladie d'Alzheimer, le sommeil et l'épilepsie : prévalence, facteurs sous-jacents et conséquences sur la consolidation mnésique Abstract: With more than 30 million people diagnosed worldwide, Alzheimer's disease (AD) is the most frequent neurodegenerative disorder. Previous research on murine models of AD highlighted the potential role of cerebral excitatory-inhibitory imbalance in the pathophysiology of AD. Clinical research has since reported that it may give rise to epileptic activities in as much as 50% of AD patients. However, these epileptic events may remain undetected due to their silent, mostly sleep-occurring nature. Therefore, the first part of this project corresponded to a preclinical study in which we aimed at (I) characterizing epileptic activities over the sleep-wake cycle in the Tg2576 mouse model and (II) gaining better insight into the mechanistic underpinnings of these peculiar epileptic events. Tg2576 mice displayed frequent epileptic activities that were predominant during REM sleep and highly locked to the phase of the theta cycle corresponding to the maximal firing probability of pyramidal cells, hinting at a potential deficit of inhibitory activity leading to hyperexcitability - which is coherent with previous results in our laboratory. Secondly, this epileptic activity seems to be prevented during wakefulness - and partially during slow-wave sleep - by noradrenergic signalling via alpha1 adrenoreceptors. In contrast, EA would be unmasked during REM sleep when noradrenergic cells cease firing. Given the early degeneration of the locus coeruleus - the primary source of noradren... Continued on ES/IODE ➡️ https://etcse.fr/hrg ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you. #alzheimer #science #health

📃Scientific paper: A translational study of the link between Alzheimer's disease, sleep and epilepsy : prevalence, underlying factorsand consequences on memory consolidation;Etude translationnelle du lien entre la maladie d'Alzheimer, le sommeil et l'épilepsie : prévalence, facteurs sous-jacents et conséquences sur la consolidation mnésique Abstract: With more than 30 million people diagnosed worldwide, Alzheimer's disease (AD) is the most frequent neurodegenerative disorder. Previous research on murine models of AD highlighted the potential role of cerebral excitatory-inhibitory imbalance in the pathophysiology of AD. Clinical research has since reported that it may give rise to epileptic activities in as much as 50% of AD patients. However, these epileptic events may remain undetected due to their silent, mostly sleep-occurring nature. Therefore, the first part of this project corresponded to a preclinical study in which we aimed at (I) characterizing epileptic activities over the sleep-wake cycle in the Tg2576 mouse model and (II) gaining better insight into the mechanistic underpinnings of these peculiar epileptic events. Tg2576 mice displayed frequent epileptic activities that were predominant during REM sleep and highly locked to the phase of the theta cycle corresponding to the maximal firing probability of pyramidal cells, hinting at a potential deficit of inhibitory activity leading to hyperexcitability - which is coherent with previous results in our laboratory. Secondly, this epileptic activity seems to be prevented during wakefulness - and partially during slow-wave sleep - by noradrenergic signalling via alpha1 adrenoreceptors. In contrast, EA would be unmasked during REM sleep when noradrenergic cells cease firing. Given the early degeneration of the locus coeruleus - the primary source of noradren... Continued on ES/IODE ➡️ https://etcse.fr/hrg ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you. #alzheimer #science #health

📃Scientific paper: A translational study of the link between Alzheimer's disease, sleep and epilepsy : prevalence, underlying factorsand consequences on memory consolidation;Etude translationnelle du lien entre la maladie d'Alzheimer, le sommeil et l'épilepsie : prévalence, facteurs sous-jacents et conséquences sur la consolidation mnésique Abstract: With more than 30 million people diagnosed worldwide, Alzheimer's disease (AD) is the most frequent neurodegenerative disorder. Previous research on murine models of AD highlighted the potential role of cerebral excitatory-inhibitory imbalance in the pathophysiology of AD. Clinical research has since reported that it may give rise to epileptic activities in as much as 50% of AD patients. However, these epileptic events may remain undetected due to their silent, mostly sleep-occurring nature. Therefore, the first part of this project corresponded to a preclinical study in which we aimed at (I) characterizing epileptic activities over the sleep-wake cycle in the Tg2576 mouse model and (II) gaining better insight into the mechanistic underpinnings of these peculiar epileptic events. Tg2576 mice displayed frequent epileptic activities that were predominant during REM sleep and highly locked to the phase of the theta cycle corresponding to the maximal firing probability of pyramidal cells, hinting at a potential deficit of inhibitory activity leading to hyperexcitability - which is coherent with previous results in our laboratory. Secondly, this epileptic activity seems to be prevented during wakefulness - and partially during slow-wave sleep - by noradrenergic signalling via alpha1 adrenoreceptors. In contrast, EA would be unmasked during REM sleep when noradrenergic cells cease firing. Given the early degeneration of the locus coeruleus - the primary source of noradren... Continued on ES/IODE ➡️ https://etcse.fr/hrg ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you. #alzheimer #science #health

📃Scientific paper: A translational study of the link between Alzheimer's disease, sleep and epilepsy : prevalence, underlying factorsand consequences on memory consolidation;Etude translationnelle du lien entre la maladie d'Alzheimer, le sommeil et l'épilepsie : prévalence, facteurs sous-jacents et conséquences sur la consolidation mnésique Abstract: With more than 30 million people diagnosed worldwide, Alzheimer's disease (AD) is the most frequent neurodegenerative disorder. Previous research on murine models of AD highlighted the potential role of cerebral excitatory-inhibitory imbalance in the pathophysiology of AD. Clinical research has since reported that it may give rise to epileptic activities in as much as 50% of AD patients. However, these epileptic events may remain undetected due to their silent, mostly sleep-occurring nature. Therefore, the first part of this project corresponded to a preclinical study in which we aimed at (I) characterizing epileptic activities over the sleep-wake cycle in the Tg2576 mouse model and (II) gaining better insight into the mechanistic underpinnings of these peculiar epileptic events. Tg2576 mice displayed frequent epileptic activities that were predominant during REM sleep and highly locked to the phase of the theta cycle corresponding to the maximal firing probability of pyramidal cells, hinting at a potential deficit of inhibitory activity leading to hyperexcitability - which is coherent with previous results in our laboratory. Secondly, this epileptic activity seems to be prevented during wakefulness - and partially during slow-wave sleep - by noradrenergic signalling via alpha1 adrenoreceptors. In contrast, EA would be unmasked during REM sleep when noradrenergic cells cease firing. Given the early degeneration of the locus coeruleus - the primary source of noradren... Continued on ES/IODE ➡️ https://etcse.fr/hrg ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you. #alzheimer #science #health

📃Scientific paper: A translational study of the link between Alzheimer's disease, sleep and epilepsy : prevalence, underlying factorsand consequences on memory consolidation;Etude translationnelle du lien entre la maladie d'Alzheimer, le sommeil et l'épilepsie : prévalence, facteurs sous-jacents et conséquences sur la consolidation mnésique Abstract: With more than 30 million people diagnosed worldwide, Alzheimer's disease (AD) is the most frequent neurodegenerative disorder. Previous research on murine models of AD highlighted the potential role of cerebral excitatory-inhibitory imbalance in the pathophysiology of AD. Clinical research has since reported that it may give rise to epileptic activities in as much as 50% of AD patients. However, these epileptic events may remain undetected due to their silent, mostly sleep-occurring nature. Therefore, the first part of this project corresponded to a preclinical study in which we aimed at (I) characterizing epileptic activities over the sleep-wake cycle in the Tg2576 mouse model and (II) gaining better insight into the mechanistic underpinnings of these peculiar epileptic events. Tg2576 mice displayed frequent epileptic activities that were predominant during REM sleep and highly locked to the phase of the theta cycle corresponding to the maximal firing probability of pyramidal cells, hinting at a potential deficit of inhibitory activity leading to hyperexcitability - which is coherent with previous results in our laboratory. Secondly, this epileptic activity seems to be prevented during wakefulness - and partially during slow-wave sleep - by noradrenergic signalling via alpha1 adrenoreceptors. In contrast, EA would be unmasked during REM sleep when noradrenergic cells cease firing. Given the early degeneration of the locus coeruleus - the primary source of noradren... Continued on ES/IODE ➡️ https://etcse.fr/hrg ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you. #alzheimer #science #health

📃Scientific paper: A translational study of the link between Alzheimer's disease, sleep and epilepsy : prevalence, underlying factorsand consequences on memory consolidation;Etude translationnelle du lien entre la maladie d'Alzheimer, le sommeil et l'épilepsie : prévalence, facteurs sous-jacents et conséquences sur la consolidation mnésique Abstract: With more than 30 million people diagnosed worldwide, Alzheimer's disease (AD) is the most frequent neurodegenerative disorder. Previous research on murine models of AD highlighted the potential role of cerebral excitatory-inhibitory imbalance in the pathophysiology of AD. Clinical research has since reported that it may give rise to epileptic activities in as much as 50% of AD patients. However, these epileptic events may remain undetected due to their silent, mostly sleep-occurring nature. Therefore, the first part of this project corresponded to a preclinical study in which we aimed at (I) characterizing epileptic activities over the sleep-wake cycle in the Tg2576 mouse model and (II) gaining better insight into the mechanistic underpinnings of these peculiar epileptic events. Tg2576 mice displayed frequent epileptic activities that were predominant during REM sleep and highly locked to the phase of the theta cycle corresponding to the maximal firing probability of pyramidal cells, hinting at a potential deficit of inhibitory activity leading to hyperexcitability - which is coherent with previous results in our laboratory. Secondly, this epileptic activity seems to be prevented during wakefulness - and partially during slow-wave sleep - by noradrenergic signalling via alpha1 adrenoreceptors. In contrast, EA would be unmasked during REM sleep when noradrenergic cells cease firing. Given the early degeneration of the locus coeruleus - the primary source of noradren... Continued on ES/IODE ➡️ https://etcse.fr/hrg ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you. #alzheimer #science #health

📃Scientific paper: A translational study of the link between Alzheimer's disease, sleep and epilepsy : prevalence, underlying factorsand consequences on memory consolidation;Etude translationnelle du lien entre la maladie d'Alzheimer, le sommeil et l'épilepsie : prévalence, facteurs sous-jacents et conséquences sur la consolidation mnésique Abstract: With more than 30 million people diagnosed worldwide, Alzheimer's disease (AD) is the most frequent neurodegenerative disorder. Previous research on murine models of AD highlighted the potential role of cerebral excitatory-inhibitory imbalance in the pathophysiology of AD. Clinical research has since reported that it may give rise to epileptic activities in as much as 50% of AD patients. However, these epileptic events may remain undetected due to their silent, mostly sleep-occurring nature. Therefore, the first part of this project corresponded to a preclinical study in which we aimed at (I) characterizing epileptic activities over the sleep-wake cycle in the Tg2576 mouse model and (II) gaining better insight into the mechanistic underpinnings of these peculiar epileptic events. Tg2576 mice displayed frequent epileptic activities that were predominant during REM sleep and highly locked to the phase of the theta cycle corresponding to the maximal firing probability of pyramidal cells, hinting at a potential deficit of inhibitory activity leading to hyperexcitability - which is coherent with previous results in our laboratory. Secondly, this epileptic activity seems to be prevented during wakefulness - and partially during slow-wave sleep - by noradrenergic signalling via alpha1 adrenoreceptors. In contrast, EA would be unmasked during REM sleep when noradrenergic cells cease firing. Given the early degeneration of the locus coeruleus - the primary source of noradren... Continued on ES/IODE ➡️ https://etcse.fr/hrg ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you. #alzheimer #science #health

📃Scientific paper: A translational study of the link between Alzheimer's disease, sleep and epilepsy : prevalence, underlying factorsand consequences on memory consolidation;Etude translationnelle du lien entre la maladie d'Alzheimer, le sommeil et l'épilepsie : prévalence, facteurs sous-jacents et conséquences sur la consolidation mnésique Abstract: With more than 30 million people diagnosed worldwide, Alzheimer's disease (AD) is the most frequent neurodegenerative disorder. Previous research on murine models of AD highlighted the potential role of cerebral excitatory-inhibitory imbalance in the pathophysiology of AD. Clinical research has since reported that it may give rise to epileptic activities in as much as 50% of AD patients. However, these epileptic events may remain undetected due to their silent, mostly sleep-occurring nature. Therefore, the first part of this project corresponded to a preclinical study in which we aimed at (I) characterizing epileptic activities over the sleep-wake cycle in the Tg2576 mouse model and (II) gaining better insight into the mechanistic underpinnings of these peculiar epileptic events. Tg2576 mice displayed frequent epileptic activities that were predominant during REM sleep and highly locked to the phase of the theta cycle corresponding to the maximal firing probability of pyramidal cells, hinting at a potential deficit of inhibitory activity leading to hyperexcitability - which is coherent with previous results in our laboratory. Secondly, this epileptic activity seems to be prevented during wakefulness - and partially during slow-wave sleep - by noradrenergic signalling via alpha1 adrenoreceptors. In contrast, EA would be unmasked during REM sleep when noradrenergic cells cease firing. Given the early degeneration of the locus coeruleus - the primary source of noradren... Continued on ES/IODE ➡️ https://etcse.fr/hrg ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you. #alzheimer #science #health