Conference Marketing Manager at Cambridge Innovation Institute | Bioprocessing | Lithium Mining | Drug Discovery | Immunogenicity | Immuno-oncology | Biopharma | Greater Boston Area
Improving Passive Membrane Permeability of Cyclic Peptides by Amide-to-Ester Substitution with Jumpei Morimoto from The University of Tokyo. Cyclic peptides are attracting increasing attention as therapeutic modalities. However, their low membrane permeability significantly limits their applications for drug discovery. Recently, our group has shown that amide-to-ester substitution is an effective strategy to improve the membrane permeability of cyclic peptides. In this presentation, I will discuss the effect of amide-to-ester substitution on membrane permeability and conformational dynamics of cyclic peptides. https://lnkd.in/eyDWU6av Save $150 with Discount code SPK150. #drugdiscoverychemistry
