Last week, a delegation of EU-LIFE attended the #EUResearchArea Conference and the 26th #ERA Forum meeting. Marta Agostinho, EU-LIFE Executive Director, advocated for a constructive policy to #AnimalResearch and the development of new approach methodologies (#NAMs) following the active role of EU-LIFE in the co-creation of the ERA action on this topic. Her main points were: • 𝗔𝘀 𝗿𝗲𝘀𝗲𝗮𝗿𝗰𝗵 𝗶𝗻𝘀𝘁𝗶𝘁𝘂𝘁𝗲𝘀 𝘄𝗲 𝗮𝗿𝗲 𝗳𝘂𝗹𝗹𝘆 𝗰𝗼𝗺𝗺𝗶𝘁𝗺𝗲𝗻𝘁 𝘁𝗼 𝘁𝗵𝗲 𝗱𝗲𝘃𝗲𝗹𝗼𝗽𝗺𝗲𝗻𝘁 𝗮𝗻𝗱 𝘂𝘀𝗲 𝗼𝗳 𝗡𝗔𝗠𝘀 that help to reduce the use of animals in research and regulatory testing. Likewise, we are fully committed to the Three Rs principle (Replacement, Reduction and Refinement). • Researchers are the ones developing NAMs, so 𝘁𝗵𝗲 𝘀𝗰𝗶𝗲𝗻𝘁𝗶𝗳𝗶𝗰 𝗰𝗼𝗺𝗺𝘂𝗻𝗶𝘁𝘆 𝗶𝘀 𝗮 𝗸𝗲𝘆 𝗽𝗹𝗮𝘆𝗲𝗿 for the success of any policy on NAMs and must be part of it at all stages. • The main value of this ERA action is the capacity to 𝗽𝗿𝗼𝗺𝗼𝘁𝗲 𝗰𝗼𝗼𝗿𝗱𝗶𝗻𝗮𝘁𝗶𝗼𝗻 𝗮𝗺𝗼𝗻𝗴 𝗠𝗲𝗺𝗯𝗲𝗿 𝗦𝘁𝗮𝘁𝗲𝘀, most specially at the regulatory stage; global coordination beyond the EU is also critical. • This action will only contribute to EU competitiveness if it allows the advancement of biomedical research and helps move science forward, 𝗯𝗮𝘀𝗲𝗱 𝗼𝗻 𝘀𝗰𝗶𝗲𝗻𝘁𝗶𝗳𝗶𝗰 𝗰𝗿𝗶𝘁𝗲𝗿𝗶𝗮 and not on political timelines. • The 𝘁𝗿𝗮𝗶𝗻𝗶𝗻𝗴 𝗮𝗻𝗱 𝗲𝗱𝘂𝗰𝗮𝘁𝗶𝗼𝗻 component of the action towards all actors - researchers, regulators, policy makers and citizens - is paramount. Informed policies must be based on broader understanding of the complexity of the biology behind biomedical research and on the potential risks, gains and impacts of the policies. Find out more here 🔗 https://bit.ly/3XUYnI0 #EuropeanResearch #ExcellentResearch
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More Relevant Posts
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Alternatives to Laboratory Animals - Latest Publication with Prof. DI Dr. Winfried Neuhaus - European network project IMPROVE COST Actions are European network projects whose work is funded by the European Commission. The aim of the IMPROVE network is to improve the quality of biomedical science with the help of concepts from the 3R area. The 3R principles deal with avoiding, reducing and refining animal testing; the 3R principles are also anchored in national law via European Regulation 2010/63. Within the network, working groups were installed on the scientific quality and translatability of preclinical data to humans, on the implementation of the 3R principles, on the dissemination of the 3R principles and on 3Rs in training. In addition to these main working groups, a cross-group working group on ethical topics has been etsablished. In addition, clearly defined questions are worked on together by the now over 230 participants. The COST Action IMPROVE has been running for 2 years and is led by Prof. DI Dr. Winfried Neuhaus. Details about the presentation of this network project can be found in the journal Alternatives to Laboratory Animals via the following link: https://lnkd.in/dw5DHZ7r #research #3Rs #replacementrefinementreduction #alternativestoanimaltesting #alternativestolaboratoryanimals #laboratorytesting #biomedicalscience #medicalethics #medizinstudium #medizinstudiumösterreich #medicaldegree #studiereninöserreich #austria #nö #wienerneustadt #krems #danubeprivateuniversity
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Researchers in the DECISION-Project developed a new animal model that allows for the study of metabolic dysfunction-associated steatohepatitis #MASH progression to #cirrhosis in just 6-8 weeks, offering a faster way to test potential treatments. Read the full story from our partners at MedB LAB Universitätsklinikum Münster and Universitätsmedizin Frankfurt: https://lnkd.in/dA6rJtmE Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) Fundació Clínic per a la Recerca Biomèdica CRI - Centre de Recherche sur l'Inflammation
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"The #FDA policy allowing non-animal data to be used to support drug approvals needs to be much better communicated and amplified by the agency, funders and research institutions. And more researchers need to embrace the change. The outcome will be more-rigorous evaluation of experimental medications, and more-meaningful results." Check out the recent Nature editorial entitled "Animal research is not always king: researchers should explore the alternatives." https://lnkd.in/daM5czXb #EthicalResearch #NonAnimalTesting #InnovativeTechnologies #AnimalTestingAlternatives #IFER
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We seem to have learnt very little from the global pandemic: 1. A pandemic the world’s leading epidemiologists have been expecting because they knew that humans are vulnerable because the line between us and exotic animals had long been breached for legal trade purposes. 2. Which is now driving up the legal ‘harvesting’ for the trade of primates for the pharmaceutical industry, as they increase research to prepare for the next pandemic. 3. And, as a result, exposing people to stressed and immune-compromised primates, increasing the risk of the next pandemic. I hear you saying, but if business and industry are doing the right thing and only buying from the legal trade what’s the problem? In addition to poor monitoring and regulation, a 2020 survey and report into green crime in company supply chains found of the business respondents who admitted they knew about environmental crime, a substantial 65% know or suspect that third parties they conduct business with may have been involved in a range of illegal, environmentally damaging activities. Only 16% of respondents say that they would report a third-party breach externally; no one is telling the necessary authorities. And, 63% of respondents agree that the economic climate is encouraging organisations to take regulatory risks in order to win new business. The trade in lab animals is booming, and it isn't all legal: https://lnkd.in/gzmVuFZg
Today is #WorldAnimalDay! 🐁 I'm taking this opportunity to share the investigation I published in Le Monde earlier this year, exposing a major failure of the French Ministère de l'Enseignement supérieur et de la Recherche. More than 20,000 scientific research projects using live animals have been authorized by the research ministry in France since 2013 outside of the regulatory framework. More precisely: these experiments received the assent of ‘ethics committees’ that were not properly registered, despite this being a requirement of the European directive 2010/63. The information was collected thanks to FOI requests made by the Transcience association, campaigning "by all legal means" for the development of scientific research without the use of animals. The problem goes deeper than a simple lack of registration, since a more in-depth examination reveals that these committees have serious shortcomings in terms of independence and impartiality, and several do not comply with the requirements for member composition. This remains largely unaddressed to this day. ‘Every year, two million sentient beings are put to death in France for scientific purposes, yet it is astonishing that no one has looked into all these shortcomings sooner’, said Muriel Obriet, President of Transcience.
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Curious to learn how we are able to predict clinical trials? My co-founder Andrey Poloznikov did an interview, explaining how we close the gap between basic research and clinical studies - read more here.
Since being recognized by the Falling Walls Foundation, we have received many questions from you. So if you want to learn more about our technology, have a look at the interview our CSO Andrey Poloznikov did with Potsdam Science Park.
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#TPcorporate - 𝗪𝗲 𝗵𝗮𝗱 𝘁𝗵𝗲 𝗵𝗼𝗻𝗼𝗿 𝗼𝗳 𝗶𝗻𝘁𝗲𝗿𝘃𝗶𝗲𝘄𝗶𝗻𝗴 𝗗𝗿. 𝗠𝗶𝗿𝗶𝗮𝗺 𝗗𝗶𝗮𝗺𝗲𝗻𝘁, Head of the Vivarium Department of Experimental Cancer at the 𝗜𝗻𝘀𝘁𝗶𝘁𝘂𝘁𝗼 𝗱𝗲 𝗢𝗻𝗰𝗼𝗹𝗼𝗴𝗶́𝗮 '𝗔́𝗻𝗴𝗲𝗹 𝗛. 𝗥𝗼𝗳𝗳𝗼' in Buenos Aires, Argentina. The doctor told us that: "𝗧𝗵𝗲 𝘄𝗲𝗹𝗳𝗮𝗿𝗲 𝗼𝗳 𝗹𝗮𝗯𝗼𝗿𝗮𝘁𝗼𝗿𝘆 𝗮𝗻𝗶𝗺𝗮𝗹𝘀 𝗽𝗹𝗮𝘆𝘀 𝗮 𝗰𝗿𝗶𝘁𝗶𝗰𝗮𝗹 𝗿𝗼𝗹𝗲 𝗶𝗻 𝘁𝗵𝗲 𝗽𝗿𝗼𝗱𝘂𝗰𝘁𝗶𝗼𝗻 𝗼𝗳 𝗿𝗲𝘀𝗲𝗮𝗿𝗰𝗵 𝗮𝗻𝗶𝗺𝗮𝗹𝘀 𝗮𝗻𝗱 𝘁𝗵𝗲 𝘀𝗰𝗶𝗲𝗻𝘁𝗶𝗳𝗶𝗰 𝗶𝗻𝘁𝗲𝗴𝗿𝗶𝘁𝘆 𝗼𝗳 𝗼𝘂𝗿 𝘄𝗼𝗿𝗸. Any alterations made to the laboratory animal environment must prioritize enhancing their physiological well-being and providing stimuli tailored to their species-specific needs. With this principle in mind, 𝘁𝗵𝗲 𝗻𝗲𝘄 𝗩𝗶𝘃𝗮𝗿𝗶𝘂𝗺 𝗲𝗻𝘀𝘂𝗿𝗲𝘀 𝘁𝗵𝗲 𝗾𝘂𝗮𝗹𝗶𝘁𝘆 𝗮𝗻𝗱 𝗿𝗲𝗽𝗿𝗼𝗱𝘂𝗰𝗶𝗯𝗶𝗹𝗶𝘁𝘆 𝗼𝗳 𝗿𝗲𝘀𝗲𝗮𝗿𝗰𝗵 𝗲𝗻𝗱𝗲𝗮𝘃𝗼𝗿𝘀. We have the capability to maintain 𝗱𝗶𝗴𝗶𝘁𝗶𝘇𝗲𝗱 𝗿𝗲𝗰𝗼𝗿𝗱𝘀 𝗼𝗳 𝗲𝗻𝘃𝗶𝗿𝗼𝗻𝗺𝗲𝗻𝘁𝗮𝗹 𝗰𝗼𝗻𝗱𝗶𝘁𝗶𝗼𝗻𝘀 in all animal rooms and receive real-time alerts for any deviations. We've also implemented a double-door autoclave in the washing area, as well as a dedicated clean storage area". 𝗗𝗼𝗻'𝘁 𝗺𝗶𝘀𝘀 𝘁𝗵𝗲 𝗳𝘂𝗹𝗹 𝗮𝗿𝘁𝗶𝗰𝗹𝗲. You can find it in our 𝗻𝗲𝘄𝘀𝗹𝗲𝘁𝘁𝗲𝗿 𝗽𝗮𝗻𝗼𝗿𝗮𝗺𝗮 at the following link: https://buff.ly/3vqQyOS #Tecniplast
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A recent editorial published in Nature Magazine calls on researchers to stay updated and explore and validate innovative alternatives. “𝐼 𝑚𝑒𝑛𝑡𝑖𝑜𝑛 𝑖𝑡, 𝑎𝑛𝑑 𝑡ℎ𝑒𝑦 𝑙𝑜𝑜𝑘 𝑎𝑡 𝑚𝑒 𝑙𝑖𝑘𝑒 𝐼 𝑓𝑒𝑙𝑙 𝑓𝑟𝑜𝑚 𝑡ℎ𝑒 𝑠𝑘𝑦” This is a common response that Ofer Levy, a vaccinologist at Boston Children´s Hospital, receives when talking about the 2022 groundbreaking law allowing researchers to test drug candidates on human tissue or computer models before First in Human trials. Levy has long advocated that studies in human tissue, in some cases, can be more informative than those done on animals. He says, “They still make use of animal models — just 70–80% less than the average research group”. This change challenges long-standing practices and offers numerous benefits. •𝐈𝐦𝐩𝐫𝐨𝐯𝐞𝐝 𝐀𝐜𝐜𝐮𝐫𝐚𝐜𝐲: Studies in human tissue can provide more relevant data than those in animal models, particularly in fields like immunology, where differences between species can give misleading results. •𝐄𝐭𝐡𝐢𝐜𝐚𝐥 𝐀𝐝𝐯𝐚𝐧𝐭𝐚𝐠𝐞𝐬: Reducing reliance on animal testing addresses ethical concerns and emotional burdens associated with animal research. What do you think are the requirements to implement these technologies in your drug development? Discussing this matter is crucial for advancing the drug development process! Feel free to share and join the discussion. Find the full editorial piece here: https://lnkd.in/daM5czXb Learn more about how Immuneed approaches this challenge here: https://lnkd.in/ds3P4DtR #InnovationInResearch #EthicalResearch #AnimalTestingAlternatives #DrugDevelopment #ResearchTechnology
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Meet the remarkable team at Animal Biotech Industries, Inc., dedicated to propelling biomedical research forward for a deeper comprehension of health and biology. Dive into the profiles of our accomplished leaders on our website to learn more! https://loom.ly/uPnz_ro #biomedicalresearch #researchcommunity #leadershipteam #biotech #research #medicalresearch
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Meet the remarkable team at Animal Biotech Industries, Inc., dedicated to propelling biomedical research forward for a deeper comprehension of health and biology. Dive into the profiles of our accomplished leaders on our website to learn more! https://loom.ly/uPnz_ro #biomedicalresearch #researchcommunity #leadershipteam #biotech #research #medicalresearch
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Meet the remarkable team at Animal Biotech Industries, Inc., dedicated to propelling biomedical research forward for a deeper comprehension of health and biology. Dive into the profiles of our accomplished leaders on our website to learn more! https://loom.ly/uPnz_ro #biomedicalresearch #researchcommunity #leadershipteam #biotech #research #medicalresearch
