Commemorating a Pioneering Mind: James Parkinson and the "Shaking Palsy’ April 11th marks a day of remembrance and respect for translational scientists worldwide as we honor James Parkinson, born on this day in 1755. Over two centuries ago, Parkinson authored an essay that would lay the foundation for understanding a complex neurological disorder that now bears his name. His work, "An Essay on the Shaking Palsy," described with meticulous care a condition characterized by "involuntary tremulous motion, with lessened muscular power." Parkinson's observant eye detailed not just the shaking that so conspicuously marked the disorder, but he also delved into the patient’s world - the daily struggle against an unseen foe that bound the body even as the mind remained sharp. His essay wasn’t just a clinical report; it was a window into the lives of those affected, written with empathy and precision. Today, translational scientists wield advanced tools and harness vast computational power, to understand disease mechanisms and look for cures. The foundational work of those like Parkinson remind us of the human element at the core of these scientific endeavors. #JamesParkinson #ShakingPalsy #TranslationalScience #DrugDiscovery
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#EducationalThursday #BrainTeaser #MemoryMatters 🧐 In 1973, scientists Tim Bliss and Terje Lømo discovered "long-term potentiation" (LTP), a phenomenon where repeated stimulation of neurons strengthens their ability to send signals to each other. ⛰ Think of it like a hiking trail: initially overgrown, but becoming clearer as more people walk along it. Similarly, repeated neuron stimulation strengthens their connections, making signal transmission easier. 🧠 This discovery is crucial because it helps us understand how memories are formed and stored in the brain. Insights from LTP research have led to treatments for Alzheimer's and other memory-related disorders, and it continues to drive brain research today. 💪 If our memories get stronger through repetition, how do our daily habits and routines affect the way we remember important events in our lives? ❔ What do you think, could the way we adapt to new technologies, such as the continuous use of our phones, affect our brain's ability to form and retain memories?
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I'm excited to share our latest paper titled 'Abnormal multisensory temporal discrimination in Parkinson’s disease,' published in Brain Research. Our study highlights how Parkinson's Disease impacts audiovisual temporal discrimination, shedding light on altered multisensory integration. We found that the order of stimuli presentation influences temporal discrimination, with auditory-first trials showing enhanced performance over visual-first trials. These findings deepen our understanding of Parkinson's Disease effects on perception and cognition. https://lnkd.in/ddk4TwZA #Parkinson #multisensory #audiovisual
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Does your brain continue to function after death? The question of what happens after death has intrigued humanity for centuries. Research suggests our brains might be active for a short time after our hearts stop beating. A study examined the brain activity of four patients using EEG (electroencephalography) during the withdrawal of life support and after cardiac arrest. The study found that in three patients, brain activity ceased before the heart stopped beating. In one patient, however, there was some residual brain activity even after the heart stopped. There are several possible explanations for the observed brain activity: Cellular Activity vs. Consciousness: Brain activity doesn't necessarily equate to consciousness. These electrical signals might be the brain's final act of shutting down. Survival Mechanism: Perhaps this surge is a last-ditch effort by the brain to keep the body alive. Memories Flashing By: This could be the scientific explanation for near-death experiences where people report seeing their lives flash before their eyes. The Mystery Continues: While this research is intriguing, it doesn't provide definitive proof of life after death. It does, however, raise fascinating questions about the dying process and the nature of consciousness. What do you think? Does this research change your perspective on death? Follow me Diella Uka for more. Join my newsletter: diellauka.substack.com Source: https://lnkd.in/dq_HZMwn #science #health #medicine
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🚀Change-Maker Empowerment & Sustainable Futures | Women in Tech & Minorities Supporter🌍 Green Energy & AI Innovator | Collaboration Maestro & AI Trailblazer | Community Architect & Dreamer Unleashed! 🌟
🧠 Does Your Brain Keep Working After Death? 🌟 The mystery of what happens after death has puzzled us for centuries. Recent studies hint that our brains might remain active for a brief period even after our hearts stop. 🔬 A study using EEG on patients showed that in some cases, brain activity continued even after the heart stopped. Here are a few theories: Final Shutdown: These signals might be the brain's last act of shutting down. Survival Mechanism: A last-ditch effort by the brain to keep the body alive. Memories Flashing: Could explain near-death experiences of life flashing before eyes. While not definitive, this research opens fascinating questions about the dying process and consciousness. 💬 What are your thoughts? Does this change your perspective on death? 🔗 Follow me for more #science #health #medicine
Does your brain continue to function after death? The question of what happens after death has intrigued humanity for centuries. Research suggests our brains might be active for a short time after our hearts stop beating. A study examined the brain activity of four patients using EEG (electroencephalography) during the withdrawal of life support and after cardiac arrest. The study found that in three patients, brain activity ceased before the heart stopped beating. In one patient, however, there was some residual brain activity even after the heart stopped. There are several possible explanations for the observed brain activity: Cellular Activity vs. Consciousness: Brain activity doesn't necessarily equate to consciousness. These electrical signals might be the brain's final act of shutting down. Survival Mechanism: Perhaps this surge is a last-ditch effort by the brain to keep the body alive. Memories Flashing By: This could be the scientific explanation for near-death experiences where people report seeing their lives flash before their eyes. The Mystery Continues: While this research is intriguing, it doesn't provide definitive proof of life after death. It does, however, raise fascinating questions about the dying process and the nature of consciousness. What do you think? Does this research change your perspective on death? Follow me Diella Uka for more. Join my newsletter: diellauka.substack.com Source: https://lnkd.in/dq_HZMwn #science #health #medicine
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Our brain lets us revel in happy memories, think of ideas that can be life-changing, and engage in a beautiful and meaningful life. 🧠 Protecting this vital organ is a pillar to healthy aging, but how do you do that, exactly? Here’s the good news—you're likely already doing things for a healthy brain, according to Mark D'Esposito, MD, a neurologist and professor of neuroscience and psychology at the University of California, Berkeley, in a recent interview with Livelong. Many thanks to D'Esposito for taking the time to share his grounded, optimistic, and realistic approach to a better brain, which is accessible to everyone—check out that interview here. https://lnkd.in/ew43niky
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Geriatric Medicine Fellow. Special interest in Chronic Pain VP Social Media Resident Geriatric Interest Group
https://lnkd.in/gee57Ktr Check out this excellent review article on Parkinson’s in NEJM!
Parkinson’s Disease | NEJM
nejm.org
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#LillyANZ acknowledges #WorldBrainDay today, a time to elevate awareness of brain health and the prevention of neurological conditions. Different factors can influence brain health. The World Health Organisation defines it as “the state of brain functioning across cognitive, sensory, social-emotional, behavioural and motor domains, allowing a person to realise their full potential over the life course, irrespective of the presence or absence of disorders.” Through ongoing clinical trials and cutting-edge research, we are committed to making scientific advancements in neuroscience that support better outcomes for people living with neurological conditions in Australia and New Zealand. Ref: World Health Organisation, 2024. Brain Health. Available at: https://lnkd.in/eSm-HZY.
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A recent study from Tufts University School of Medicine has shed new light on the effects of Traumatic Brain Injury, revealing that the damage extends far beyond the direct site of injury. The research, found that both hemispheres of the brain collaborate to form new neural pathways, trying to compensate for the lost ones. Which, suggests that the brain's function after a TBI is fundamentally different from its normal state, highlighting the remarkable plasticity of the brain and its ability to adapt to damage. This discovery has significant clinical implications for better diagnosing the impact of injuries and enhancing individualized treatment strategies. Learn more: https://lnkd.in/gQcGU8bv One love #braininjury #awareness #invisibledisability
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BRAIN-funded research allows scientists to embrace the complexity of the brain. This means describing the brain’s cell types, tracing their connections and functions, and recording the activity of millions of cells. Dr. Walter Koroshetz, Director of the National Institute of Neurological Disorders and Stroke, explores what makes the BRAIN Initiative unique in this new blog series: https://lnkd.in/gVGDf5ZX #studyBRAIN #NIH
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Today's the day! We're excited to kick off the Inaugural Summit on Subconcussive Trauma and Brain Health. Over the next two days, leaders in sports medicine, neuroscience, and public health will come together to advance our understanding of subconcussive impacts and discuss solutions to protect brain health. Follow along as we dive into this important issue. #SubconcussiveSummit #BrainHealth
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