European Annals of Allergy and Clinical Immunology’s Post

Rosella Gallo, Ilaria Trave, 𝗚𝗶𝘂𝗹𝗶𝗮 𝗚𝗮𝘀𝗽𝗮𝗿𝗶𝗻𝗶, 𝗥𝗶𝗰𝗰𝗮𝗿𝗱𝗼 𝗖𝗮𝘀𝘁𝗲𝗹𝗹𝗶, 𝗚𝗶𝘂𝗹𝗶𝗮 𝗠𝗲𝗿𝗹𝗼, aurora parodi, 𝗘𝗺𝗮𝗻𝘂𝗲𝗹𝗲 𝗖𝗼𝘇𝘇𝗮𝗻𝗶 discuss a rare form of chronic inducible urticaria (CIndU) known as 𝗮𝗾𝘂𝗮𝗴𝗲𝗻𝗶𝗰 𝘂𝗿𝘁𝗶𝗰𝗮𝗿𝗶𝗮 (AquaU), specifically focusing on a 𝘀𝗮𝗹𝘁-𝗱𝗲𝗽𝗲𝗻𝗱𝗲𝗻𝘁 𝘀𝘂𝗯𝘁𝘆𝗽𝗲 (SDAU). AquaU is a rare condition where contact with #water, regardless of temperature, causes #hives on the #skin. Predominantly affects young #females; most cases are sporadic. The exact cause is unknown, but hypotheses include the generation of a 𝘁𝗼𝘅𝗶𝗰 𝘀𝘂𝗯𝘀𝘁𝗮𝗻𝗰𝗲 𝗼𝗿 𝗮𝘂𝘁𝗼-𝗮𝗹𝗹𝗲𝗿𝗴𝗲𝗻 𝗳𝗿𝗼𝗺 𝘄𝗮𝘁𝗲𝗿-𝘀𝗼𝗹𝘂𝗯𝗹𝗲 𝗰𝗼𝗺𝗽𝗼𝗻𝗲𝗻𝘁𝘀 𝗶𝗻 𝘁𝗵𝗲 𝘀𝗸𝗶𝗻. The symptoms are highly pruritic urticarial #rashes triggered by #sea bathing, tap water, #swimmingpool water, and #sweat. Nine female patients diagnosed with SDAU underwent tests with tap water and a 3.5% NaCl solution. The tests helped identify the #𝘀𝗲𝗻𝘀𝗶𝘁𝗶𝘃𝗶𝘁𝘆 𝘁𝗼 𝘀𝗮𝗹𝘁𝘆 𝘄𝗮𝘁𝗲𝗿, suggesting that #salinity might be a relevant parameter for AquaU.

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