European College of Neuropsychopharmacology (ECNP)’s Post

Peripheral neuropathies, including chronic pain and diabetic neuropathy, affect many patients and there is an urgent need for new treatments. Increasing the understanding of common underlying disease mechanisms provides an opportunity for advancing drug development. At Cellectricon, we have long-standing experience in supporting our clients in accelerating their drug discovery programs by providing in vitro services for target discovery and validation as well as lead discovery. In collaboration with leading industry partners, we have developed several in vitro disease models for assessing changes in key phenotypes, such as neuronal hyperexcitability and axonal outgrowth. Reach out to learn more about our platform for drug discovery and to explore how we may support your research. https://lnkd.in/eqmvGsrQ   #neuroscience #drugdiscovery #targetdiscovery #leaddiscovery #neurobiology #invitro #research #peripheralneuropathy #neuropathy

By coupling mass spectrometry with cell type-specific in vivo biotinylation of proteins (CIBOP), Kumar et al. are able to resolve native state proteomes from physically unaltered cell subtypes in vivo. In their latest publication in nature communications (PMID 38561349), they identified potential molecular vulnerabilities of parvalbumin-expressing interneurons to neurodegeneration in Alzheimer’s disease using our guinea pig antibody against parvalbumin (195 004).   #neuroscience #antibodies #parvalbumin #CIBOP #Alzheimersdisease

The approval of Donanemab is a significant milestone in the fight against Alzheimer's. However, mAbs like Donanemab come with safety concerns such as brain swelling and brain bleeds (ARIA-E/H) in up to 30% of cases. They are also expensive ($32K annually plus hospital costs) and require inconvenient administration, limiting their use in AD asymptomatic individuals where immunotherapy (whether mAb or vaccine) is most effective. In contrast, AD vaccines likely do not have these shortcomings and offer a potentially safer and more convenient alternative, provided these vaccines achieve high and long-lasting antibody titers. #Immunotherapy #Vaccines Nuravax

📢 NEW DATA from bit.bio's human iPSC-derived ioGlutamatergic Neurons and ioMicroglia highlights how Sartorius successfully maintained healthy neuronal and microglial co-cultures over 50 days. Using continuous live-cell monitoring, the study demonstrated stable network activity and synchronised calcium oscillations, demonstrating consistent, reproducible insights over extended experimental timelines. In a Huntington’s disease model (ioGlutamatergic Neurons HTT 50CAG), disruptions in synaptic signalling shed light on altered cellular communication—offering potential insights into the progression of neurodegenerative diseases. Curious to learn more? https://hubs.ly/Q02SYC9n0 #Neuroscience #iPSCs #LiveCellAnalysis #NeuronalActivity #Microglia #HuntingtonsDisease #optiox #ioCells #sartorius

Inspiring updates from Dr. Carlos Romo at the Children's Tumor Foundation’s NF Global Conference! As the Director of Clinical Research for NTAP at Johns Hopkins Medicine and a passionate physician-researcher, Dr. Romo highlighted the latest breakthroughs in therapies and ongoing research focused on improving treatment options for individuals with NF1 and cutaneous neurofibromas (cNF). His contributions are instrumental in advancing care and enhancing the quality of life for those affected by these conditions. We're currently enrolling participants for an adult study to evaluate the safety and tolerability of mirdametinib, a MEK inhibitor, and its potential effectiveness in treating cutaneous neurofibromas in people with NF1. Learn more at: https://lnkd.in/egqk3Wj7 #NF1Therapies #Neuroscience #NFAwareness #Neurofibromatosis #EndNF

📢 #Publication alert 🩸Vascular #dementia (VaD), the second most common form of #dementia (after #Alzheimers disease), is associated with cerebrovascular dysfunction, often as a consequence of chronic vascular damage and reduced blood flow in the #brain. 🐁Dr Latha Diwakar's lab developed a mouse model of VaD. This was done using the vasoconstricting peptide Endothelin-1 (ET-1) to mimic recurrent transient ischemic attacks. The findings show that ET-1 disrupts the blood-brain barrier, leading to neuronal loss and memory impairment. However, co-administering pleiotrophin helps restore barrier integrity and memory function! 🧠This model will aid in exploring the underlying mechanisms of VaD and may provide insights for the development of promising therapies. 📑Please read the full story on Experimental Neurology @Elsevier here: https://lnkd.in/dG6VPyg7 Mayank . | Ankita Talukdar | Shobha Anilkumar ,PhD | Thomas Issac | Latha Diwakar #Aging #Neuroscience #Neurodegeneration #VascularHealth #BrainHealthMatters

Selective vulnerabilities within vascular subpopulations associated with clinically diagnosed Alzheimer's disease (AD) were unveiled in a recent research, revealing pivotal transcriptomic perturbations. Significantly, the study validates the expression of genes associated with AD risk, identified through genome-wide association studies (GWASs), across diverse human brain vascular cell types. This insight places these genes within the vascular context, shedding light on targeted therapeutic interventions. A fascinating study by Yang, et al. on Nature “A human brain vascular atlas reveals diverse mediators of Alzheimer’s risk.” #alzheimers #dementia #GWAS #snRNAseq #snRNA #singlenuclei #neuroscience #BioTuring Read the publication here: https://lnkd.in/gbW6Nzmw Explore the dataset on Talk2Data now: https://lnkd.in/gmfztFeJ 

795,000 people suffer a #stroke each year in the United States, but recent research continues to uncover neuro-biomarkers with the potential to monitor complications and healing progression after a stroke. One of these #biomarkers is S100b. In a study following 80 stroke patients, researchers identified S100b in acute ischemic stroke clots as a key biomarker for post-thrombectomy intracranial hemorrhages. This finding sheds light on thromboinflammation dynamics. BioIVT's entorhinal cortical brain tissue served as positive control, contributing to these findings. https://hubs.ly/Q02x-9rJ0 #Neuroscience #Biomarkers #StrokeAwarenessMonth

Cross-talk between different areas of the mPFC influences top-down control over behaviour. https://lnkd.in/dpNjY2_V #neuroscience #neuroplasticity #neuralpathways #neuralnetworks #neuralcircuits #neuromodulation #PFC

🌟 Exciting Event Announcement! 🌟 Join us in Rome, Italy, for the Neuro Biomarkers and Biosignatures Conference 2025 on June 9-10! This is a unique opportunity to dive into the latest advancements in neuro biomarkers and biosignatures, connect with leading experts, and explore groundbreaking research in the field. 📅 Dates: June 9-10, 2025 📍 Location: Rome, Italy 🎟️ Early Bird Registration is Now Open! Secure your spot and take advantage of our early bird rates. Register here: https://lnkd.in/eDdQdedk Don’t miss out on the chance to be at the forefront of neurobiological research and innovation. We look forward to seeing you in Rome! #NeuroBiomarkers #Biosignatures #Neuroscience #NeurodegenerativeDiseases #Neuroimaging #GeneticMarkers #Proteomics #Neurogenetics #ClinicalDiagnostics #Neuroinflammation #AlzheimerDisease #ParkinsonDisease #MultipleSclerosis #BiomarkerDiscovery #BrainFunction #CognitiveDisorders #Neuroplasticity #NeuropsychiatricDisorders #BiomarkerValidation #BiomarkerProfiling #NeurochemicalMarkers #Neuroimmunology #Neurotoxicity #EarlyDetection #PersonalizedMedicine #DiseaseMechanisms #FunctionalMRI #Electrophysiology #MachineLearning #Neuroscience #Clinicaltrials